In this case report, we describe an uncommon case of neuroendocrine cancer of unknown origin began with cauda equina syndrome in a patient affected by Paget disease of bone (PDB). A 76-year-old man with diagnosis of PDB, without history of pain or …

Paget disease of bone (PDB) is a focal disorder of bone metabolism characterized by an abnormal, accelerated rate of bone remodeling at one (monostotic PDB) or more (polyostotic PDB) skeletal sites [ 1 ]. The prevalence of PDB in the elderly …

Paget’s disease of bone (PDB) is a disease in which a remodeling abnormality of bone at regional sites leads to altered microstructure, morphologic swelling, or bone deformation, resulting in decreased local bone strength [ 1 – 4 ]. Although PDB is …

Paget’s disease of bone (PDB) is a common, late-onset bone disorder, characterized by focal increases of bone turnover that can result in bone lesions. Heterozygous pathogenic variants in the Sequestosome 1 (SQSTM1) gene are found to be the main …

Paget’s disease of bone (PDB) is a rare metabolic bone disorder, which is extremely rare in Asian population. This study aimed to investigate the phenotypes and the pathogenic mutations of woman with early-onset PDB. The clinical features, bone …

Paget’s disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar …

Paget’s disease of bone (PDB) is a skeletal disorder distinguished by disorganized bone remodeling due to abnormal activation of osteoclasts that results in abnormal bone resorption and compensatory osteogenic sclerosis [ 1 , 2 ]. The femur, tibia …

Paget’s disease of bone (PDB) is a focal disorder of bone remodelling of unknown aetiology which may lead to bone pain, secondary osteoarthritis, bone deformity, fractures, and other less frequent clinical manifestations such as hearing loss …

Paget’s disease is a progressive, uni- or multifocal disorder of the bone. Affected sites show greatly increased bone turnover, with bone rarefaction, sclerosis or a combination of these changes depending on the balance of osteoblast and …

Paget’s disease of bone (PDB) is a metabolic bone disease with distinct geographical and ethnic differences in its pathogenesis. In this study, we aimed to retrospectively analyze the clinical features and the status of diagnosis and treatment of …

Adequate vitamin D status is essential for skeletal health. Paget’s disease of bone (PDB) is a common metabolic skeletal disorder, but data regarding the vitamin D status in PDB patients are lacking. We performed a case–control study to estimate …

Paget’s disease of bone (PDB) is a frequently asymptomatic disorder of bone remodeling that typically affects people over the age of 55 and is characterized by discrete skeletal lesions with intermixed osteolytic and osteosclerotic pathology.

Paget’s disease of bone (PDB) is a common bone disorder characterized by focal lesions caused by increased bone turnover. Monogenic forms of PDB and PDB-related phenotypes as well as genome-wide association studies strongly support the involvement …