Skip to main content
8628 search results for:

Opioid Antagonist 

sort by |
"newest" sorts results by publication date. "most relevant" also considers factors like how often the search phrase is in the result.
  1. Open Access 01-12-2023 | Magnetic Resonance Imaging | OriginalPaper

    Effects of a peripherally acting µ-opioid receptor antagonist for the prevention of recurrent acute pancreatitis: study protocol for an investigator-initiated, randomized, placebo-controlled, double-blind clinical trial (PAMORA-RAP trial)

    Note: the numbers in curly brackets in this protocol refer to SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see …

  2. Open Access 01-06-2022 | Naltrexone | ReviewPaper

    Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?

    Opioids are cornerstone in the management of perioperative pain, but their use is also linked to potential worse oncological outcomes [ 1 ]. Mu-opioid receptor (MOR) is overexpressed in many cancer types versus normal tissue[ 1 – 10 ] and its …

  3. 01-03-2022 | Buprenorphine | ReviewPaper

    Effects of opioid receptor agonist and antagonist medications on electrocardiogram changes and presentation of cardiac arrhythmia: review article

    Abuse of opioid medications is a significant public health concern in the USA. In 2019, more than 14,000 deaths occurred due to overdoses involving prescription opioids [ 1 ]. It is estimated that the total economic burden of prescription opioid

  4. 01-06-2021 | Naloxone | Letter

    Acute motor effects induced by opioid antagonists in Parkinson’s disease: could naloxone be a rescue therapy?

  5. 01-06-2021 | Methylnaltrexone | ReviewPaper

    Selective Opioid Antagonists Following Bowel Resection for Prevention of Postoperative Ileus: a Systematic Review and Meta-analysis

    Postoperative ileus (POI), defined as impairment of gastrointestinal motility, occurs following bowel resection at a rate of 10 to 30%. 1 , 2 The pathophysiology of POI is related to underlying hormonal, inflammatory, and neurogenic responses to …

  6. 01-03-2021 | Naloxegol | ReviewPaper

    Insights into the Use of Peripherally Acting μ-Opioid Receptor Antagonists (PAMORAs) in Oncologic Patients: from Scientific Evidence to Real Clinical Practice

    Management of chronic pain is crucial to improve the quality of life of cancer and palliative care patients. Opioid-based treatments used to control pain can be prolonged over time. Unfortunately, constipation is one of the most disturbing adverse …

  7. 01-02-2020 | Naltrexone | OriginalPaper

    Pharmacokinetics and Bioequivalence Evaluation of a New Oxycodone Tamper-Resistant Tablet Administered with an Opioid Antagonist in Patients with Chronic Pain

    Oxycodone is a semisynthetic opioid indicated for the treatment of moderate-to-severe pain. It acts as a strong agonist at mu- and kappa-opioid receptors, with a specific pharmacological profile and, when administered orally, shows greater …

  8. 01-06-2017 | ReviewPaper

    Antagonist Treatment for Opioid Dependence: Promise and Hurdles

    Relapse rates among treatment-seeking opioid-addicted individuals are extremely high but can be markedly reduced by agonist-based maintenance therapies such as methadone or buprenorphine. However, these therapies are not always available due to a …

  9. Open Access 01-12-2021 | Methylnaltrexone | OriginalPaper

    Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity: study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial

    Note: the numbers in curly brackets in this protocol refer to SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see …

  10. Open Access 01-01-2021 | Naloxegol | ReviewPaper

    Peripherally Acting μ-Opioid Receptor Antagonists in the Management of Postoperative Ileus: a Clinical Review

    Postoperative ileus (POI) and constipation are common secondary effects of opioids and carry significant clinical and economic impacts. μ-Opioid receptors mediate opioid analgesia in the central nervous system (CNS) and gastrointestinal-related …

  11. 01-12-2020 | Methylnaltrexone | OriginalPaper

    The association between N-methylnaltrexone, a peripherally acting mu-opioid receptor antagonist, and clinical outcomes in patients undergoing robotic-assisted radical cystectomy

    Radical cystectomy (RC) with pelvic lymph node dissection (PLND) and urinary diversion is the gold standard treatment for muscle-invasive bladder cancer (MIBC) and high-risk non-muscle-invasive bladder cancer (NMIBC) [ 1 , 2 ]. In the hands of …

  12. 01-02-2012 | ReviewPaper

    Effect of opioid antagonists on sex hormone secretion

    Background: Endogenous opioids have roles in various functions in different parts of the body, including intestinal motility, suppression of pain, reinforcement of behavior, and regulation of the hypothalamic-pituitary-gonadal axis. The endogenous …

  13. Open Access 01-12-2012 | OriginalPaper

    In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera

    Opioids are the most widely used analgesics in the treatment of various pain states. Early binding studies and functional bioassays defined three main types of opioid receptors in the central nervous system: μ- (MOR), δ- (DOR) and κ- (KOR) …

  14. Open Access 01-09-2017 | OriginalPaper

    Pharmacokinetic Bioequivalence Studies of an Extended-Release Oxycodone Hydrochloride Tablet in Healthy Japanese Subjects Under Fasting and Fed Conditions Without an Opioid Antagonist

    Oxycodone is a semisynthetic opioid used for the treatment of moderate to severe pain. Two separate studies were conducted to assess the pharmacokinetic bioequivalence of a newly formulated oxycodone hydrochloride extended-release tablet to a …

  15. 01-07-1997 | OriginalPaper

    The hypothalamic-pituitary-luteal axis in women: Effects of long-term orally active opioid antagonist (naltrexone) administration

    Aim of our study is to assess the effect of a long-term oral opiate antagonist treatment during the luteal phase on the hypothalamic-pituitary-ovarian axis. Fourteen normovulatory women partecipated to the study. Immediately after the ovulation …

  16. 01-08-2013 | ReviewPaper

    Treatment of Opioid-Induced Constipation: Focus on the Peripheral μ-Opioid Receptor Antagonist Methylnaltrexone

    Most prescribed opioids exert their analgesic effects via activation of central μ-opioid receptors. However, μ-opioid receptors are also located in the gastrointestinal (GI) tract, and activation of these receptors by opioids can lead to …

  17. 01-08-2012 | News

    Pharmacological options for maintenance treatment of opioid dependence include opioid agonists and antagonists

    Opioid dependence is a chronic, relapsing condition that manifests as addiction to heroin and pharmaceutical opioids.[ 1 ] A worldwide increase in the misuse of opioids has been observed.[ 2 ] Globally, there are an estimated 15.6million illicit …

  18. 01-06-2013 | News

    Opioid receptor antagonists/general anaesthetics/clonidine/midazolam

    Various toxicities during ultra rapid opioid detoxification: 3 case reports
  19. 01-01-1998 | OriginalPaper

    Combined Opioid-NMDA Antagonist Therapies

    What Advantages Do They Offer for the Control of Pain Syndromes?

    The potential beneficial effect of coadministration of opiates with antagonists of the N-methyl-D-aspartate (NMDA) receptor for glutamate are discussed. There is a growing body of experimental data indicating that selective NMDA antagonists acting …

  20. 01-11-1998 | OriginalPaper

    Opioid Receptor Antagonists in Psychiatry

    Beyond Drug Addiction

    The central role of the opioid system and its multiple connections to other neurotransmitter and neuroendocrine systems favours its involvement in many physiological functions and behaviours and, as a consequence, in many disorders, including …

Filter search results

Search Operators:

„ ... ... “ Finds documents with exactly this word group, in exactly this word order and spelling (e.g., "employer branding").
AND Finds documents with both search terms (e.g., sales AND bonus).
OR Finds documents with one or the other search term (e.g., porsche OR volkswagen).
Blank Space Finds documents with all search terms. Blank space is understood as AND (e.g., man robot production).
NOT Finds documents with no appearance of the word behind NOT (e.g., ford NOT "harrison ford").
COUNT(...)>n Finds documents where the search term is mentioned at least "n" times."n" may be any number (e.g., COUNT(gear)>8).
NEAR(..., ..., ) Finds documents with both search terms in any word order, permitting "n" words as a maximum distance between them. Best choose between 15 and 30 (e.g., NEAR(recruit, professionals, 20)).
* Finds documents with the search term in word versions or composites. The star * marks whether you wish them BEFORE, BEHIND, or BEFORE and BEHIND the search term (e.g., lightweight*, *lightweight, *lightweight*).
? Finds documents with the search termn in different spellings."?" allows only one character (e.g., organi?ation).
& + - Special characters are understood as AND (e.g., Miller Bros. & Sons).

You can use operators in your search query to narrow down your results even more.

Tap the operator, or hover the mouse pointer over it, to read more about how it works.