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257 search results for:

Methylnaltrexone 

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  1. 01-11-2020 | Methylnaltrexone | News

    Methylnaltrexone bromide

    Free air, elevated lactic acid and frank bowel perforation: 3 case reports
  2. Open Access 01-06-2021 | Methylnaltrexone | OriginalPaper

    The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation

    For patients receiving opioid therapy for pain, constipation is the most bothersome gastrointestinal-related adverse effect [ 1 , 2 ]. Opioids inhibit gastric emptying and delay gastrointestinal transit time by binding to gastrointestinal μ-opioid …

  3. Open Access 01-06-2021 | Nausea | ReviewPaper

    Efficacy and Safety of Methylnaltrexone for the Treatment of Opioid-Induced Constipation: A Meta-analysis of Randomized Controlled Trials

    This article is published with digital features, including a summary slide, to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.6084/m9.figshare.13614500 .

  4. 01-01-2022 | Methylnaltrexone | News

    Methylnaltrexone-bromide

    Lack of efficacy: case report
  5. Open Access 01-06-2021 | Methylnaltrexone | Erratum

    Correction to: The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation

    A correction to this paper has been published: https://doi.org/10.1007/s40266-021-00860-8 …

  6. 01-09-2021 | Methylnaltrexone

    The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies

    When conservative pharmacologic measures are inadequate to treat cancer-related pain, opioid treatment should be considered. Opioids activate the endogenous pain-modulating system through agonism of several opioid receptor types such as μ-, κ- …

  7. 01-10-2019 | Naltrexone | News

    Methylnaltrexone-bromide

    Acute eosinophilic pneumonia: case report
  8. 01-04-2020 | Methylnaltrexone | OriginalPaper

    Methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients. Results from the MOTION trial

    Bowel dysfunction in the intensive care unit (ICU) represents an important problem, with up to 70% of patients suffering from constipation [ 1 ]. There is increasing evidence that opioids contribute to perioperative and ICU bowel dysfunction [ 2 ].

  9. Open Access 01-12-2021 | Methylnaltrexone | OriginalPaper

    Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity: study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial

    Note: the numbers in curly brackets in this protocol refer to SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see …

  10. 01-12-2020 | Methylnaltrexone | OriginalPaper

    The association between N-methylnaltrexone, a peripherally acting mu-opioid receptor antagonist, and clinical outcomes in patients undergoing robotic-assisted radical cystectomy

    Radical cystectomy (RC) with pelvic lymph node dissection (PLND) and urinary diversion is the gold standard treatment for muscle-invasive bladder cancer (MIBC) and high-risk non-muscle-invasive bladder cancer (NMIBC) [ 1 , 2 ]. In the hands of …

  11. 01-05-2010 | OriginalPaper

    Methylnaltrexone

    Methylnaltrexone is a selective μ-opioid receptor antagonist that has restricted ability to cross the blood-brain barrier, thus enabling reversal of opioid-induced peripheral effects, such as constipation, without affecting the central effects …

  12. 01-11-2006 | OriginalPaper

    Methylnaltrexone

    MNTX

    Methylnaltrexone is a peripheral opioid receptor antagonist undergoing phase III clinical trials for the treatment of opioid-induced constipation in patients with advanced medical illness who are being treated with narcotics for pain. The compound …

  13. 01-12-2014 | News

    Methylnaltrexone bromide

    Abdominal pain and diarrhoea: 8 case reports
  14. 01-09-2014 | News

    Methylnaltrexone bromide

    Nausea, flatulence and dizziness in a paediatric patient: case report
  15. 01-11-2013 | News

    Methylnaltrexone bromide/morphine interaction

    Vomiting in an elderly patient: case report
  16. 01-11-2012 | Abstract

    Methylnaltrexone bromide/opioid analgesics

    Narcotic bowel syndrome and exacerbated abdominal pain: 4 case reports
  17. 01-06-2008 | Abstract

    Methylnaltrexone for opioid-induced constipation

  18. 01-03-2005 | Abstract

    Methylnaltrexone alleviates opioid-induced constipation

  19. 01-06-2006 | Abstract

    Methylnaltrexone: relieving opioid-induced constipation

  20. 01-09-2005 | Abstract

    Methylnaltrexone: positive results in opiate-induced constipation

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