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4239 search results for:

Ocular Melanoma 

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  1. 28-02-2024 | Melanoma | OriginalPaper

    Assessment of Social Vulnerabilities of Care and Prognosis in Adult Ocular Melanomas in the US

  2. Open Access 18-02-2023 | Brachytherapy | OriginalPaper

    Ocular oncology service during the COVID-19 outbreak: uveal melanoma characteristics presenting in 2019 compared to 2020

    The COVID-19 pandemic is an ever-evolving situation and an ongoing challenge to our already stretched healthcare system. The treatment of ocular malignancies is considered non-deferrable and should proceed despite the pandemic. Delays in the …

  3. 02-03-2023 | Choroidal Melanoma | Letter

    Trans-scleral uveal melanoma biopsy: can it be safely and accurately incorporated into a medium volume ocular oncology service?

  4. Open Access 01-12-2019 | Metastasis | OriginalPaper

    Natural killer cells and pigment epithelial-derived factor control the infiltrative and nodular growth of hepatic metastases in an Orthotopic murine model of ocular melanoma

    Uveal Melanoma (UM) is the most common intraocular malignancy in adults [ 1 , 2 ]. Despite effective control of the primary tumor, about 50% of UM patients develop metastatic disease. The mortality rate of these patients has not significantly …

  5. Open Access 01-06-2019 | Pharyngitis | OriginalPaper

    Safety of Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Liver Metastases from Ocular Melanoma Using the Delcath Systems’ Second-Generation Hemofiltration System: A Prospective Non-randomized Phase II Trial

    The superiority of percutaneous hepatic perfusion with melphalan (M-PHP) over best available care in controlling liver disease in patients with metastases from ocular and cutaneous melanoma has been demonstrated in a phase III randomized …

  6. Open Access 01-02-2021 | Metastasis | OriginalPaper

    Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Ocular Melanoma Metastases Confined to the Liver: A Prospective Phase II Study

    This prospective, single-arm, single-center, phase II study was conducted in accordance with the Declaration of Helsinki, approved by the local ethics committee and registered on www.trialregister.nl (NTR4112). All participants provided written …

  7. Open Access 01-12-2019 | Melanoma | OriginalPaper

    m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation

    N 6 -Methyladenosine (m 6 A), the most prevalent modification in mRNA [ 1 , 2 ], is a dynamic RNA modification installed by “writer” methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14) and Wilms tumor associated protein (WTAP) [ …

  8. 01-02-2020 | Melanoma | OriginalPaper

    Multi-center analysis of intraocular biopsy technique and outcomes for uveal melanoma: Ocular Oncology Study Consortium report 4

    With the advent of molecular diagnostics such as chromosomal analysis [ 1 , 2 ] and gene expression profiling (GEP) [ 3 ], prognostic uveal melanoma (UM) fine-needle aspiration biopsy (FNAB) at the time of plaque brachytherapy has become a common …

  9. Open Access 01-12-2021 | Choroidal Melanoma | OriginalPaper

    Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma

    Uveal melanoma (UM) is a rare disease, with a maximum incidence of 8 per million in Europe, but it represents the most common primary cancer of the eye [ 1 ]. For decades, proton beam therapy has been widely used as the primary treatment for …

  10. Open Access 01-11-2020 | Cholangiocarcinoma | OriginalPaper

    Chemosaturation with percutaneous hepatic perfusion is effective in patients with ocular melanoma and cholangiocarcinoma

    The Hepatic CHEMOSAT® Delivery System (Delcath Systems Inc., New York, NY, USA) is an innovative medical device for the treatment of patients with unresectable primary or secondary liver tumors. The system is used to perform chemosaturation …

  11. Open Access 01-12-2020 | Metastasis | BriefCommunication

    ASO Author Reflections: Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Hepatic Metastases from Ocular Melanoma

    Up to 50% of patients with ocular melanoma will develop metastatic disease with predominant liver involvement. Because effective systemic treatments are lacking, liver-directed therapies play a key role in the management of these patients. The …

  12. 01-02-2020 | Metastasis | OriginalPaper

    Predictors of Overall and Progression-Free Survival in Patients with Ocular Melanoma Metastatic to the Liver Undergoing Y90 Radioembolization

    Ocular melanoma is the most common primary intraocular malignancy in adults [ 1 ]. Approximately half of patients develop metastatic disease within 15 years from diagnosis [ 1 ] with the liver being the most common site of metastatic disease [ 2 ].

  13. Open Access 01-12-2019 | Magnetic Resonance Imaging | Letter

    Reaction on “Ocular ultrasound versus MRI in the detection of extrascleral extension in a patient with choroidal melanoma

    Given the recent attention on the use of MRI for the diagnosis of ocular lesions, especially for uveal melanoma, the article of Jacobsen et al. [ 1 ] is most timely. It is furthermore commendable of the authors to share their experience of an …

  14. 01-06-2015 | OriginalPaper

    Diffusion-weighted magnetic resonance imaging for predicting and detecting the response of ocular melanoma to proton beam therapy: initial results

    Uveal melanoma is the most common primary intraocular tumour in adults [ 1 ]. The earliest treatment for uveal melanoma was removal of the eye. Today, enucleation has been supplanted by radiotherapy as the standard of care for patients with uveal …

  15. Open Access 01-12-2018 | OriginalPaper

    Ocular ultrasound versus MRI in the detection of extrascleral extension in a patient with choroidal melanoma

    Uveal melanoma is the most common intraocular malignancy and represents 5% of all melanoma diagnoses in the United States [ 1 , 2 ]. Currently ocular ultrasound is the imaging modality of choice in monitoring the progression of uveal melanoma and …

  16. Open Access 01-12-2016 | OriginalPaper

    A case report of a patient with metastatic ocular melanoma who experienced a response to treatment with the BRAF inhibitor vemurafenib

    Two subtypes of primary ocular melanoma have been described, uveal and conjunctival. Conjunctival malignant melanoma (CMM) is a rare condition with an incidence of 0.2 to 0.8 per million in Caucasian populations. It is a frequently lethal …

  17. Open Access 01-12-2016 | OriginalPaper

    Pancreatic metastases from ocular malignant melanoma: the use of endoscopic ultrasound-guided fine-needle aspiration to establish a definitive cytologic diagnosis: a case report

    Malignant pancreatic lesions generally arise from the gland itself. Nonpancreatic primary metastases are rare but usually seen in patients with widely metastatic disease [ 1 ]. The frequency of this finding is variable, from 4.5 % in case series up …

  18. 01-09-2008 | OriginalPaper

    Episcleral melanoma as a complication of ocular melanocytosis

    Ocular melanoma typically arises from the uveal tract or conjunctiva. The finding of primary episcleral melanoma is exceedingly rare. Ocular melanocytosis has been associated with the development of uveal melanoma, but, to our knowledge, it has …

  19. 01-08-1998 | OriginalPaper

    Indications for surgical resection of metastatic ocular melanoma

    A case report and review of the literature
  20. 01-12-2004 | Letter

    Acute leukemia in a patient with ocular melanoma

    Is it induced by intraocular brachytherapy or only a bad fate?

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