Melanoma is the most common fatal type of skin cancer, and its incidence continues to rise [ 1 , 2 ]. In the United States melanoma incidence increased from 20.7 per 100,000 in 2001 to 28.2 per 100,000 in 2015 [ 3 ]. Superficial spreading melanoma …

Malignant melanoma (MM) arises predominantly after adolescence, while the incidence in the prepubertal population is extremely low, and the incidence in people under the age of 20 is about 0.0005 %-0.0006 % [ 1 ], most of which are 10 or over the …

Uveal Melanoma (UM) is the most common intraocular malignancy in adults [ 1 , 2 ]. Despite effective control of the primary tumor, about 50% of UM patients develop metastatic disease. The mortality rate of these patients has not significantly …

Nodular melanoma (NM) is a rare subtype of melanoma, accounting for about 14% of all cases but at the same time responsible for more than 40% of melanoma deaths. It is characterized by rapid growth and high metastatic potential [ 1 ]. Therefore, it …

Skin melanoma has become the sixth most common cancer in the United States, but it is still a relatively rare disease in Asia. Early diagnosis is the best way to improve the prognosis in patients with melanoma. Unfortunately, early diagnosis of …

In Caucasians, incidences of malignant melanoma (MM) are increasing worldwide, with estimated continuous case increases for the next decades. The highest incidence is found in Queensland, Australia (about 70 cases/100.000/year). In the USA, an …

Cutaneous melanoma is a rare, aggressive skin malignancy with a high mortality rate. The incidence varies among countries, with lower incidence in Asian populations compared to Caucasian populations. Estimates report 0.43–0.48 new cases per …

Only 1% of all melanomas arise from mucosa; most melanomas arise from skin [ 1 ]. Mucosal melanomas arise primarily in the head and neck, anorectal, and vulvovaginal regions. Of all colorectal malignancies, anorectal mucosal melanomas are rare …

In the original version of this article [1], published on 7 November 2017, affiliation 18 has been incorrectly assigned to the authors Serena Magi and Laura Mazzoni. They are only affiliated to the Skin Cancer Unit, Istituto Tumori Romagna (IRST) …

The incidence of melanoma is increasing worldwide with highest rates in northern Europe, United States and Australia [ 1 ]. The most commonly prognostic parameters in the recent AJCC/UICC staging model are breslow thickness (BT), ulceration and …

Sclerosing angiomatoid nodular transformation (SANT) as a particular lesion of the spleen was initially described by Martel and colleagues in 2004 [ 1 ]. It is generally assumed that many of these lesions were previously classified as inflammatory …

The study population consisted of all consecutive melanoma patients who underwent a wide excision with a 1–2 cm margin according to the international melanoma guidelines and a SLNB at the University Medical Center Groningen (UMCG) between 1996 and …

The two major melanoma histologic subtypes, superficial spreading and nodular melanomas, are believed to differ in their speed of dermal invasion but to converge biologically once they invade and metastasize. Here, we tested the hypothesis that …

Melanoma is a neoplasm derived from melanocytes of the skin and other sites. It accounts for 1% to 3% of all malignancies and 1% to 2% of all cancer deaths worldwide. Recently, melanoma has become a major health problem in many countries. The …

Multiple features are important for the progress of cutaneous melanoma, like alterations of tumor cell proliferation and cell cycle regulation, cell adhesion proteins, and tumor associated angiogenesis [ 1 – 3 ]. Although necrosis and tumor cell …