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38299 search results for:

Molecular Tumor Biology 

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  1. Open Access 01-12-2023 | Breast Cancer | OriginalPaper

    Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations

    Breast cancer (BC) is the most frequently diagnosed cancer in the USA and the second most common cause of cancer-related death in women [ 1 ], although there have been significant advances in treatment strategies over the past few decades. In …

  2. 01-12-2021 | Medulloblastoma | OriginalPaper

    Effects of different molecular subtypes and tumor biology on the prognosis of medulloblastoma

    Medulloblastoma is one of the most common childhood malignant brain tumors, with an incidence of 0.74 per 100,000 population [ 27 ]. Most cases are found in the posterior fossa; 30% can occur with spinal and leptomeningeal disseminations [ 8 ]. Ten …

  3. 01-06-2016 | ReviewPaper

    Molecular biology of testicular germ cell tumors

    Testicular germ cell tumors (TGCTs) are the most common solid tumors in young adult men. They constitute a unique pathology because of their embryonic and germ origin and their special behavior. Genetic predisposition, environmental factors …

  4. 01-08-2016 | ReviewPaper

    Recent advances in molecular biology and treatment strategies for intracranial germ cell tumors

  5. 01-12-2006 | OriginalPaper

    Molecular biology of testicular germ cell tumors

    Testicular germ cell tumors (TCGT) comprise a heterogeneous group of neoplasms, although all of them are originated from common precursors related to germ cell lineage. Understanding of normal development of germinal cells is essential to define …

  6. 01-12-2010 | ReviewPaper

    Tumor-infiltrating lymphocytes and hepatocellular carcinoma: molecular biology

    Tumor-infiltrating lymphocytes (TIL) are one of the representative components of host antitumor immune responses. Both the quality and quantity of TIL determine the effect of the antitumor immune reaction. Previous studies have indicated that …

  7. 01-12-2003 | OriginalPaper

    Potential applications of molecular biology in neuroendocrine tumors

    The impact of molecular biology procedures on neuroendocrine (NE) tumor biology is gradually evolving from purely academic and research studies to clinical applications. This review deals with applications of molecular techniques in neuroendocrine …

  8. 01-07-2006 | OriginalPaper

    Molecular biology of malignant melanoma and other cutaneous tumors

    Skin cancer is the most common cancer worldwide. Its incidence is doubling every 15–20 years likely because of an aging population, changes in behaviour towards sun exposure, and increased UV light fluency at the earth surface due to ozone …

  9. 01-09-2009 | ReviewPaper

    The molecular biology of pituitary tumors: a personal perspective

    Oncogenes and tumor suppressor genes involved in most common cancers are not involved in the great majority of pituitary adenomas. Similarly, there is little evidence to suggest that the mutations involved in genetic syndromes associated with …

  10. 01-04-2015 | ReviewPaper

    Molecular Biology of Pediatric Brain Tumors and Impact on Novel Therapies

    Brain tumors are the leading cause of cancer-related death in children. For the past several decades, therapeutic strategies have centered on cytotoxic chemotherapy and radiation therapy due, in part, to limited understanding of genetic events …

  11. 01-09-2016 | OriginalPaper

    A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study

    Telomerase activation is critical in many cancers including central nervous system (CNS) tumors. Imetelstat is an oligonucleotide that binds to the template region of the RNA component of telomerase, inhibiting its enzymatic activity. We conducted …

  12. 01-03-2014 | OriginalPaper

    Molecular biology of neuroendocrine tumors: from pathways to biomarkers and targets

    Neuroendocrine tumors (NETs) represent a heterogeneous group of diseases with varied natural history and prognosis depending upon the organ of origin and grade of aggressiveness. The most widely used biomarker to determine disease burden and …

  13. 01-01-2009 | OriginalPaper

    Molecular profiling of pediatric brain tumors: Insight into biology and treatment

    Recent history has witnessed unparalleled advances in our understanding of tumor biology, owing in large part to the publication of the human genome project. Paired with improvements in microarray technologies, the combination of genetic and …

  14. 01-10-2000 | OriginalPaper

    Application of advances in molecular biology to the treatment of brain tumors

    Recent advances in molecular biology have substantially improved our understanding of the molecular genetics of primary brain neoplasms. Soon each histopathologic category of glioma will be further divided into subgroups according to similar …

  15. 01-04-2004 | OriginalPaper

    New insights into the pathology and molecular biology of human germ cell tumors

    The group of human germ cell tumors (GCTs) is heterogeneous, and comprises neoplasms found at different anatomical locations. They are of interest not only for aspects of their tumor biology, but also from the point of view of developmental …

  16. 01-04-2012 | ReviewPaper

    Impact of Molecular Biology Studies on the Understanding of Brain Tumors in Childhood

    Pediatric brain tumors are the second most common form of childhood malignancy. Brain tumors are a very heterogenous group of tumors and the pathogenesis of many of these tumors is yet to be clearly elucidated. Current diagnostic tools include …

  17. 01-06-2012 | ReviewPaper

    Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker

    Ubiquitin-conjugating enzyme 2C (UBE2C) participates in cell cycle progression and checkpoint control by targeted degradation of short-lived proteins. As a conjugating enzyme, it directs polyubiquitination to preferred lysine in the substrates. In …

  18. 01-05-2009 | OriginalPaper

    The evolution and application of techniques in molecular biology to human brain tumors: a 25 year perspective

    Since the establishment of the AANS/CNS Section on Tumors in 1984, neurosurgeons have been actively involved in basic science research of human brain tumors that has moved the field forward considerably. Here, we chronicle the major advances that …

  19. Open Access 01-12-2009 | OriginalPaper

    Expression of somatostatin receptor subtypes in human thyroid tumors: the immunohistochemical and molecular biology (RT-PCR) investigation

    Human endocrine tumors often express the somatostatin receptors SSTR 1–5 with different intensity. It has been widely investigated their distribution in pituitary adenomas, brain tumors, adrenal tumors and neuroendocrine tumors in gastrointestinal …

  20. 01-07-2008 | OriginalPaper

    The importance of molecular biology in development, prognosis, treatment and resistance to targeted therapy in gastrointestinal stromal tumors

    Gastrointestinal stromal tumors (GISTs) are the commonest mesenchymal tumors of the gastroenteric tract, and are generally believed to originate from the neoplastic transformation of the interstitial cells of Cajal, the pacemaker structures of the …

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