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Lyme Disease 

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  1. Open Access 04-05-2024 | Lyme Disease | Online First

    Opposing Patterns of Spatial Synchrony in Lyme Disease Incidence

    Incidence of Lyme disease, a tick-borne illness prevalent in the US, is increasing in endemic regions and regions with no previous history of the disease, significantly impacting public health. We examined space–time patterns of Lyme disease

  2. Open Access 05-04-2024 | Lyme Disease | Online First

    Borrelia burgdorferi and autoimmune mechanisms: implications for mimicry, misdiagnosis, and mismanagement in Lyme disease and autoimmune disorders

    The genus Borrelia encompasses a diverse group of spirochetes transmitted primarily by ticks, with Borrelia burgdorferi causing Lyme disease, which is prevalent in North America and Europe. Borrelia’s structural adaptations and ability to persist …

  3. Open Access 01-12-2024 | Cytokines | OriginalPaper

    Genome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications

    Lyme borreliosis (LB) is an infectious disease transmitted by ticks infected with Borrelia burgdorferi sensu lato ( B. burgdorferi s.l.) spirochetes. Although infection occurs in a minority of individuals after a tick bite, in both Europe and the …

  4. Open Access 13-03-2024 | Lyme Disease | Online First

    By-degree Health and Economic Impacts of Lyme Disease, Eastern and Midwestern United States

    Lyme disease (LD) is the most common vector-borne disease in the United States (U.S.). This paper assesses how climate change may influence LD incidence in the eastern and upper Midwestern U.S. and the associated economic burden. We estimated …

  5. Open Access 01-12-2024 | Lyme Disease | OriginalPaper

    Knowledge, protective behaviours, and perception of Lyme disease in an area of emerging risk: results from a cross-sectional survey of adults in Ottawa, Ontario

    Lyme disease is a tick-borne bacterial illness caused by Borrelia burgdorferi transmitted, in the North American northeast, through the bite of infected Ixodes scapularis (blacklegged) ticks [ 1 ] . It is the most common vector-borne disease

  6. Open Access 01-12-2023 | Lyme Disease | OriginalPaper

    Leveraging machine learning approaches for predicting potential Lyme disease cases and incidence rates in the United States using Twitter

    Lyme disease has been one of the most reported infectious diseases in the United States (US) and accounts for over $$90\%$$ 90 % of all vector-borne diseases in North America [ 1 – 4 ]. Since 1991 Lyme disease has become an officially notifiable …

  7. Open Access 01-12-2023 | Lyme Disease | OriginalPaper

    Outpatient visits before and after Lyme disease diagnosis in a Maryland employer-based health plan

    Lyme disease (LD) is a tick-borne infection caused by various genospecies of the bacteria Borrelia burgdorferi sensu lato complex [ 1 ]. The Centers for Disease Control and Prevention (CDC) has estimated that 476,000 patients are diagnosed and …

  8. Open Access 01-12-2022 | Tick | OriginalPaper

    Incidence and associated factors of cetuximab-induced hypersensitivity infusion reactions in 1392 cancer patients treated in four French areas: a possible association with Lyme disease?

    Cetuximab is a recombinant human-murine chimeric immunoglobulin G1 monoclonal antibody targeting the human epidermal growth factor receptor (EGFr) by competitively inhibiting the binding of EGF and other ligands on non-tumoral and tumoral cells [ 1 …]. Cetuximab has been approved for the treatment of metastatic colorectal cancer in association with anticancer chemotherapy regimen (only for wild type Rat Sarcoma Virus (RAS) status) and advanced head and neck squamous cell carcinoma (HNSCC), in combination with radiotherapy or platinum-based anticancer chemotherapy regimen [

  9. Open Access 01-12-2023 | Doxycycline | OriginalPaper

    Efficacy and safety of antibiotic therapy for post-Lyme disease? A systematic review and network meta-analysis

    Lyme disease (LD) is an infectious disease caused by Borrelia burgdorferi. Its clinical manifestation is mainly nervous system damage. At the moment, the clinical evaluation and treatment of persistent symptoms after treatment of Lyme disease have …

  10. Open Access 01-12-2021 | Tick | OriginalPaper

    Public perceptions of Lyme disease and climate change in southern Manitoba, Canada: making a case for strategic decoupling of climate and health messages

    Climate change is now considered the “biggest global health threat of the 21st century” [ 1 ]. Climate health impacts vary across regions and demographics, ranging from heat-related illnesses, increased aeroallergens impacting asthma, worsened air …

  11. 16-12-2022 | Tick | OriginalPaper

    Anaplasmosis and Lyme disease

  12. Open Access 01-12-2022 | Migrating Redness | OriginalPaper

    Non-specific symptoms and post-treatment Lyme disease syndrome in patients with Lyme borreliosis: a prospective cohort study in Belgium (2016–2020)

    Lyme borreliosis (LB) is an important tick-borne disease caused by spirochetes of the Borrelia burgdorferi sensu lato (s.l.) complex. As the spirochetes can affect different sites of the body, it can manifest with a broad variety of clinical …

  13. Open Access 01-12-2020 | Magnetic Resonance Imaging | OriginalPaper

    Normal pressure hydrocephalus secondary to Lyme disease, a case report and review of seven reported cases

    The chronic phases of infection with the spirochete Borrelia Burgdorferi (Bb), European Lyme disease is characterized by involving several organ systems. Involvement of the nervous system, neuroborreliosis, can develop in untreated individuals …

  14. 01-12-2020 | Tick | Case Study

    A painless erythematous swelling of the external ear as a manifestation of Lyme disease: a case report

    Lyme disease is endemic in North America, and is the most common cause of tick-borne illness in the USA, Canada, and Europe [ 1 ]. Zoonotic transmission occurs after tick bites from various Ixodes species. Typical species include Ixodes scapularis …

  15. 01-02-2022 | Tick | ReviewPaper

    A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist

    Lyme disease is an infection caused by Borrelia burgdorferi sensu lato, which is transmitted to humans through the bite of an infected Ixodes tick. The majority of patients recover without complications with antibiotic therapy. However, for a …

  16. Open Access 01-12-2020 | Tick | OriginalPaper

    Telephone versus web panel National Survey for monitoring adoption of preventive behaviors to climate change in populations: a case study of Lyme disease in Québec, Canada

    With the unavoidable warming of the climate system more frequent climatic hazards, such as heat waves and floods, will result in greater health impacts on the population [ 1 ]. For instance, higher heat exposure due to average temperature warming …

  17. Open Access 01-12-2022 | Tick | OriginalPaper

    Spatiotemporal trends and socioecological factors associated with Lyme disease in eastern Ontario, Canada from 2010–2017

    Currently, there is limited knowledge about socioeconomic, neighbourhood, and local ecological factors that contribute to the growing Lyme disease incidence in the province of Ontario, Canada. In this study, we sought to identify these factors …

  18. Open Access 01-12-2022 | Tick | OriginalPaper

    Behavioral risk factors associated with reported tick exposure in a Lyme disease high incidence region in Canada

    Climate change and modifications in land use are altering the distribution, survival and behaviors of multiple tick species in North America, which can carry human and animal pathogens [ 1 ]. In North America, Lyme Disease (LD) is primarily caused …

  19. 01-12-2022 | Lyme Disease

    Knowing the entire story – a focus group study on patient experiences with chronic Lyme-associated symptoms (chronic Lyme disease)

    Most healthcare professionals – and general practitioners in particular – will have encountered patients with chronic symptoms We define a symptom as any physical sensation that is described by the patient in relation to their illness, irrespective …

  20. 30-09-2021 | Lyme Disease | Letter

    Black-white differences in the clinical manifestations and timing of initial Lyme disease diagnoses

    Black patients are less represented in medical textbooks [ 1 ]. This underrepresentation may make it more difficult for physicians to recognize the dermatologic manifestations of certain diseases in black patients [ 2 ]. For Lyme disease, this may …

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