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60 search results for:

Levomethadone 

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  1. 01-12-2021 | Levomethadone | News

    Levomethadone/peginterferon

    QT prolongation and diabetes mellitus: 2 case reports
  2. 01-03-2013 | News

    Levomethadone

    Renal failure, liver failure and erectile dysfunction following intracavernous injection: case report
  3. 01-09-2013 | News

    Levomethadone overdose

    Confusion, fatigue and loss of consciousness due to drug intoxication: case report
  4. 01-02-2017 | OriginalPaper

    Elevated methylation and decreased serum concentrations of BDNF in patients in levomethadone compared to diamorphine maintenance treatment

    Brain-derived neurotrophic factor (BDNF) appears to play a crucial role in the reward response to drugs such as heroin. The primary objective of the present study was to examine epigenetic changes and serum levels of BDNF in patients undergoing …

  5. 01-11-2008 | OriginalPaper

    Successful prophylactic treatment of chronic cluster headache with low-dose levomethadone

  6. Open Access 01-12-2014 | OriginalPaper

    Patterns of non-compliant buprenorphine, levomethadone, and methadone use among opioid dependent persons in treatment

    Methadone maintenance treatment for opioid dependent patients was introduced in Germany in 1988 as part of a pilot study[ 1 ]. Since then, opioid maintenance or substitution treatment (OST) has expanded to include buprenorphine in 2000 and …

  7. 01-12-2021 | Levomethadone | OriginalPaper

    Patients’ Perceptions of Opioid Replacement Therapy: a Comparison of Diamorphine and Methadone/Levomethadone

    Diamorphine was first legalized as a novel treatment option for heroin dependence in Germany in 2009. Today, specialized clinics in ten German cities provide diamorphine to heavily addicted patients. As the medical and societal context of …

  8. Open Access 29-02-2024 | Opioids | OriginalPaper

    The Dose-Response Relationship between Opioid Agonist Therapy and Alterations in Pain Pathways in Patients with Opioid Use Disorders: A Cross-Sectional Study

    Opioid use disorder (OUD) affects approximately 40 million people worldwide, with substantial biopsychosocial consequences for individual health as well as socioeconomic effects for the community. Opioid agonist therapy (OAT) is a treatment …

  9. Open Access 27-11-2023 | Dextromethorphan | OriginalPaper

    Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism

    Major depressive disorder is a functionally severely disabling condition characterized by depressed mood, loss of interest in activities of daily life, lack of motivation, and cognitive dysfunction. It has been estimated that approximately 70% of …

  10. Open Access 08-03-2023 | Levomethadone | ReviewPaper

    Esmethadone-HCl (REL-1017): a promising rapid antidepressant

    This review article presents select recent studies that form the basis for the development of esmethadone into a potential new drug. Esmethadone is a promising member of the pharmacological class of uncompetitive N-methyl-D-aspartate receptor …

  11. 01-09-2023 | Pancreatitis | News

    Multiple drugs

    Necrotising pancreatitis, atypical haemolytic uremic syndrome and thrombotic microangiopathy: case report
  12. Open Access 06-02-2024 | OriginalPaper

    Development and Pilot Testing of an Algorithm-Based Approach to Anticholinergic Deprescribing in Older Patients

    In geriatric medicine, anticholinergic adverse drug reactions have increasingly become the focus of many interventions designed to assess or improve prescribing quality. Although anticholinergic drugs are useful in specific indications, their …

  13. Open Access 01-06-2021 | Opioids | ReviewPaper

    New Approaches in Drug Dependence: Opioids

    Harm reduction subsumes a variety of compassionate and pragmatic strategies focusing on minimizing substance-related harm and enhancing quality of life for affected individuals and their communities without requiring abstinence or reduction of …

  14. Open Access 01-12-2020 | Buprenorphine | OriginalPaper

    Dispensation of attention deficit hyperactivity disorder (ADHD) medications in patients receiving opioid agonist therapy; a national prospective cohort study in Norway from 2015 to 2017

    The strong association between opioid addiction and attention deficit hyperactivity disorder (ADHD) is well known [ 1 ]. Studies indicate that up to a third of patients receiving opioid agonist therapy (OAT) meet the criteria for ADHD [ 1 – 5 ].

  15. Open Access 01-12-2020 | Opioids | OriginalPaper

    Dispensations of benzodiazepines, z-hypnotics, and gabapentinoids to patients receiving opioid agonist therapy; a prospective cohort study in Norway from 2013 to 2017

    Dispensations of benzodiazepines, z-hypnotics, and gabapentinoids to patients on opioid agonist therapy (OAT) have pros and cons. These drugs may increase the mortality among patients on OAT and are associated with criminality, psychosocial …

  16. 01-07-2019 | Opioids | ReviewPaper

    Comprehensive Perioperative Management Considerations in Patients Taking Methadone

    One hundred million adults in the USA live with chronic pain and more than 2 million individuals seek treatment for substance abuse, including opioid abuse [ 1 ]. Within this population, there are a large number of opioid-tolerant individuals …

  17. 01-05-2019 | Liver Transplantation | News

    Mycophenolate-mofetil/tacrolimus interaction

    Acute kidney injury: case report
  18. Open Access 01-06-2022 | Levomethadone | OriginalPaper

    D,L-Methadone enhances the cytotoxic activity of standard chemotherapeutic agents on pediatric rhabdomyosarcoma

    Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma, accounting for 5% of all cases of pediatric solid tumors (Dasgupta et al. 2016 ). The two main histopathological subtypes of this malignancy in children are embryonal (RME) and alveolar …

  19. Open Access 23-08-2022 | Opioids | OriginalPaper

    Prescription of opioid analgesics for non-cancer pain in Germany: study protocol for a mixed methods analysis

    Opioid analgesics are utilized in the treatment of different indications, including acute severe pain, e.g., following trauma, burns or surgery, and for patients with painful terminal diseases. However, long-term use of opioid analgesics for …

  20. Open Access 01-12-2019 | Levomethadone | OriginalPaper

    Opioid use disorder in Germany: healthcare costs of patients in opioid maintenance treatment

    Opioid use disorder (OUD) is a substance use disorder characterized by compulsive opioid use, typically resulting in the development of tolerance and withdrawal after stopping the intake of the drug. Currently, there are several options available …

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