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Lennox Gastaut Syndrome 

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  1. 08-05-2024 | Vagus Nerve Stimulation | Online First

    A survey of preferences and expectations for surgical interventions targeting atonic seizures in Lennox-Gastaut syndrome

    Approximately 30% of children with epilepsy are refractory to anti-seizure medications (ASMs) and have drug-resistant epilepsy (DRE). A substantial proportion of patients with DRE have generalized or multifocal epilepsies and are not candidates …

  2. Open Access 01-12-2024 | OriginalPaper

    Fenfluramine for the treatment of status epilepticus: use in an adult with LennoxGastaut syndrome and literature review

    Refractory status epilepticus (SE) is characterized by unresponsiveness to initial therapy with benzodiazepines and anti-seizure medications (ASMs). It occurs in approximately 40–50% of all cases of SE [ 1 ]. Status epilepticus is associated with …

  3. Open Access 01-12-2023 | Tuberous Sclerosis | OriginalPaper

    Efficacy analysis of oral dexamethasone in the treatment of infantile spasms and infantile spasms related LennoxGastaut syndrome

    Infantile spasms (IS) and IS-related LennoxGastaut syndrome (LGS) are common intractable epileptic encephalopathies in children [ 1 , 2 ]. Although both conditions are age-dependent, the onset age of IS predominantly occurs within the first year …

  4. 23-06-2023 | Lennox Gastaut Syndrome | OriginalPaper

    Lennox-Gastaut Syndrome: Current Treatments, Novel Therapeutics, and Future Directions

    Lennox-Gastaut syndrome is a severe drug-resistant developmental and epileptic encephalopathy with slow spike and wave on EEG (DEE-SSW) composing about 1–2% of epilepsy patients. Seizures in DEE-SSW are caused by a variety of etiologies, and there …

  5. Open Access 01-12-2022 | Vagus Nerve Stimulation | OriginalPaper

    Development of localized interictal epileptiform discharges following vagus nerve stimulation for lennox-gastaut syndrome: a case report

    Vagus nerve stimulation (VNS) has been approved by the US Food and Drug Administration for the treatment of epilepsy and depression in patients aged > 12 years [ 1 , 2 ]. Approximately 40% of patients treated with VNS show a 50% reduction of …

  6. Open Access 01-07-2023 | Lennox Gastaut Syndrome | Erratum

    Correction to: Fenfluramine: A Review in Dravet and Lennox-Gastaut Syndromes

  7. Open Access 15-06-2023 | Dravet Syndrome | ReviewPaper

    Fenfluramine: A Review in Dravet and Lennox-Gastaut Syndromes

    Fenfluramine (Fintepla®) is an oral anti-seizure medication (ASM) with a novel mechanism of action consisting of activity in the serotonergic system coupled with positive allosteric modulation effects at sigma-1 receptors. Originally approved for …

  8. Open Access 01-12-2023 | Epilepsy | ReviewPaper

    The burden of illness in LennoxGastaut syndrome: a systematic literature review

    The recognition of a specific disease entity is vital for every aspect of patient care, from diagnosis, management and treatment to advancements in health outcomes through research and health policy (Fig 1 ). The definition of LennoxGastaut

  9. Open Access 01-12-2021 | Epilepsy | OriginalPaper

    Truncating mutation in TANC2 in a Chinese boy associated with Lennox-Gastaut syndrome: a case report

    Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy in which the epileptiform abnormalities may contribute to progressive dysfunctions [ 1 ], characterized by polymorphic seizures and neuropsychological decline [ 2 ]. LGS may arise …

  10. Open Access 01-01-2021 | Clobazam | ReviewPaper

    Expanding the Treatment Landscape for Lennox-Gastaut Syndrome: Current and Future Strategies

    Lennox-Gastaut syndrome (LGS), a childhood-onset severe developmental and epileptic encephalopathy (DEE), is an entity that encompasses a heterogenous group of aetiologies, with no single genetic cause. It is characterised by multiple seizure …

  11. 24-09-2022 | Epilepsy | ReviewPaper

    Fenfluramine for the Treatment of Dravet Syndrome and Lennox Gastaut Syndrome: A Review

    Treatment-resistant epilepsy comprises approximately 36.3% of neurology clinic-based populations in the USA [ 1 ]. Despite new drug development over the past 50 years, the rates of drug-resistant epilepsy remain the same [ 1 ]. The need for …

  12. 01-03-2017 | ReviewPaper

    Lennox-Gastaut Syndrome: a Current Review

    Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy of onset in the school age child who may or may not have a pre-existing epilepsy or neurologic disorder. The etiology of LGS may be cryptogenic (i.e., unknown) or symptomatic and …

  13. Open Access 01-06-2021 | Epilepsy | OriginalPaper

    LennoxGastaut Syndrome: Perspective of a Parent and a Physician

    This article is co-authored by a parent of a 32-year-old male patient with LennoxGastaut syndrome (LGS) and his epileptologist. It discusses the parent’s experience of having a child with LGS from diagnosis through living day-to-day with the …

  14. 01-09-2021 | Electroencephalography

    Clinical Trial Outcome Measurements in Lennox-Gastaut Syndrome and Their Application to the Development of Targeted Treatments

    Lennox-Gastaut syndrome (LGS) is a severe childhood epileptic encephalopathy marked by multiple seizure subtypes, characteristic electroencephalography (EEG) findings, and cognitive/behavioral deficits [ 1 ]. The median age at diagnosis is 4 years …

  15. 01-08-2021 | Epilepsy | OriginalPaper

    Efficacy and safety of corpus callosotomy and ketogenic diet in children with Lennox Gastaut syndrome: a systematic review and meta-analysis

    Lennox Gastaut syndrome (LGS) is one of the difficult to control electroclinical epilepsy syndromes with onset in early childhood. Patients with LGS usually have different types of seizures including atonic seizure, tonic seizure, myoclonic …

  16. 01-10-2020 | Antiepileptic Drugs | ReviewPaper

    Fenfluramine for the Treatment of Dravet Syndrome and LennoxGastaut Syndrome

    The last 50 years has seen the introduction of a great number of antiepileptic drugs, relieving the burden of seizures for many patients. However, some conditions remain a challenge for epileptologists, especially Dravet syndrome and …

  17. Open Access 01-03-2021 | Tuberous Sclerosis | ReviewPaper

    Highly Purified Cannabidiol for Epilepsy Treatment: A Systematic Review of Epileptic Conditions Beyond Dravet Syndrome and LennoxGastaut Syndrome

    Epilepsy is one of the most common chronic disorders of the brain and affects approximately 70 million people worldwide [ 1 , 2 ]. Most patients with epilepsy can reach sustained remission, while around one third continues to have seizures despite …

  18. Open Access 01-04-2021 | Dravet Syndrome | Letter

    Comment on “Cost-Effectiveness of Cannabidiol Adjunct Therapy Versus Usual Care for the Treatment of Seizures in Lennox-Gastaut Syndrome

  19. 01-04-2021 | Lennox Gastaut Syndrome | Letter

    Authors’ Reply to Comment on “Cost-Effectiveness of Cannabidiol Adjunct Therapy Versus Usual Care for the Treatment of Seizures in Lennox-Gastaut Syndrome

  20. 01-11-2020 | Antiepileptic Drugs | OriginalPaper

    Cost-Effectiveness of Cannabidiol Adjunct Therapy versus Usual Care for the Treatment of Seizures in Lennox-Gastaut Syndrome

    Lennox-Gastaut Syndrome (LGS) is a rare epileptic encephalopathy characterized by frequent seizures and cognitive disability. Annual incidence is estimated to be two to nine cases per 100,000 people [ 1 , 2 ], which accounts for 1–10% of all …

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