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Lactase Deficiency 

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  1. 01-02-2019 | Lactase Deficiency | Letter

    Primary lactase deficiency and bone mineral density in postmenopausal women

  2. 01-02-2019 | Letter

    Osteoporosis risk of the subjects with isolated lactase enzyme deficiency

  3. 01-11-2018 | ReviewPaper

    Does primary lactase deficiency reduce bone mineral density in postmenopausal women? A systematic review and meta-analysis

    The ramifications of osteoporotic bone fractures on public health are well-recognized [ 1 ]. Postmenopausal osteoporosis is a primary risk factor and an important predictor of bone fractures [ 2 ]. There are defined and well-known risk factors for …

  4. Open Access 01-12-2015 | OriginalPaper

    A novel mutation within the lactase gene (LCT): the first report of congenital lactase deficiency diagnosed in Central Europe

    Congenital lactase deficiency (CLD, OMIM #223000) is a rare but severe gastrointestinal disorder. Characteristic symptoms are osmotic diarrhoea with subsequent dehydration and loss of weight despite adequate caloric intake. Symptoms begin during …

  5. Open Access 01-12-2009 | OriginalPaper

    Four novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD)

    Congenital lactase deficiency (CLD [MIM 223000]) is a severe form of lactase deficiency in which lactase activity is very low or absent in the intestinal wall from birth [ 1 , 2 ]. The main symptoms are watery diarrhoea in the first days of life …

  6. 01-04-2016 | Letter

    Could a poor outcome of gastro-oesophageal reflux surgery be related to lactase deficiency?

    Complications of surgery for gastro-oesophageal reflux disease can provoke severe symptoms that condemn the patient to a very poor quality of life. A similar clinical picture is presented among patients with lactase deficiency, which is highly …

  7. Open Access 01-12-2023 | Anaphylaxis | OriginalPaper

    The cow’s milk allergy that wasn’t: allergy to supplemental oral lactase enzyme

    Lactose intolerance is a common condition characterized by abdominal pain, nausea, bloating, and diarrhea after ingestion of lactase-containing products such as cow’s milk. In most patients, this is due to acquired lactase deficiency caused by a …

  8. 22-07-2023 | Diarrhea | ReviewPaper

    Diet and Management of Diarrhea

    Diet plays an important role in human health and disease. Of all human diseases, diarrheal illnesses bring diet into sharp focus as it has a direct causal and therapeutic relationship. With the advent and widespread use of next generation …

  9. 18-03-2024 | Lactose Intolerance | Online First

    Added Value of 13C Analysis in Breath Tests in H2-Negative Subjects to Diagnose Lactose Malabsorption: A Proof of Concept Study

    Lactose is a disaccharide that requires hydrolysis into its constituent monosaccharides galactose and glucose to enable intestinal absorption [ 1 ]. Hydrolysis of the disaccharide is performed by the lactase enzyme located on the small bowel brush …

  10. 01-12-2022 | School | OriginalPaper

    Prevalence of lactose intolerance and malabsorption among children of two ethnic groups from the urban areas of Malaysia and its relation to calcium intake and bone health status

    Primary lactase deficiency was reported to affect approximately 68% of the world population [ 1 ]. The prevalence varies according to ethnicity and is related to milk and dairy product consumption. Primary lactase deficiency happens more frequently …

  11. 27-06-2023 | Diarrhea | ReviewPaper

    Approach to a Child with Chronic Diarrhea

    Chronic diarrhea in children is challenging both with regards to etiological diagnosis and for management. Etiology and pathophysiological mechanisms vary widely from neonates to adolescents. Congenital or genetic causes are more frequent in …

  12. 23-12-2023 | Chronic Kidney Disease | OriginalPaper

    Association between the serum zinc level and nutritional status represented by the geriatric nutritional Rrisk index

    Zinc is an important trace element, involved in the activities of numerous enzymes [ 1 , 2 ], and it is necessary for its anti-oxidative and anti-inflammatory effects in the human body [ 3 ]. It is well-known that serum zinc levels are low in …

  13. 30-12-2023 | Diarrhea | ReviewPaper

    Getting the BS out of Irritable Bowel Syndrome with Diarrhea (IBS-D): Let’s Make a Diagnosis

    The dictionary defines “syndrome” as “a group of signs and symptoms that occur together and characterize a particular abnormality or condition.” [Merriam-Webster.com, accessed 8/7/23] For irritable bowel syndrome (IBS), the symptoms include …

  14. Open Access 01-12-2024 | OriginalPaper

    Development of prescribing indicators related to opioid-related harm in patients with chronic pain in primary care—a modified e-Delphi study

    Opioids are potent analgesics with a dependent tendency that can effectively relieve acute surgical and cancer pain [ 1 , 2 ]. They are used routinely, safely and effectively for people with life-limiting illnesses and in palliative care, often for …

  15. 27-03-2024 | Eosinophilic Esophagitis | ReviewPaper

    Minimally Invasive Approaches to Diagnose and Monitor Eosinophilic GI Diseases

    Eosinophilic gastrointestinal diseases (EGIDs) are chronic inflammatory diseases characterized histologically by the dense intestinal eosinophilia. Disease management of EGIDs is challenging due to the lack of definitive biomarkers outside of …

  16. 30-01-2024 | Prostate Cancer | ReviewPaper

    The Dairy and Cancer Controversy: Milking the Evidence

    In 2020, an estimated 17 million Americans were living with cancer [ 1 ]. A nutritious diet is an important part of care for those living with a malignant disease [ 2 , 3 ]. Cancer risk reduction is a topic of interest for people with or without a …

  17. Open Access 01-12-2020 | Diarrhea | OriginalPaper

    A retrospective study on the association of gastrointestinal symptoms in children with low lactase activity and low activity of other disaccharidases

    Disaccharides including lactose, maltose, sucrose, and isomaltose are a major part of the human diet, and for the past few decades the consumption of sugars has increased globally especially in children, and though decreasing in a few countries …

  18. Open Access 01-12-2024 | Galactosemia | OriginalPaper

    A case report of classic galactosemia with a GALT gene variant and a literature review

    Galactosemia is an autosomal recessive disorder resulting in galactose accumulation in the body due to defective enzyme function-associated disorders of the galactose metabolic pathway, which interfere with normal cell physiological functions [ 1 …

  19. 18-12-2023 | Diarrhea | ReviewPaper

    Approach to Congenital Diarrhea and Enteropathies (CODEs)

    Congenital diarrhea and enteropathies (CODEs) constitute a group of rare genetic disorders characterized by severe diarrhea and malabsorption in the neonatal period or early infancy. Timely diagnosis and treatment is essential to prevent …

  20. Open Access 18-05-2023 | Irritable Bowel Syndrome | ReviewPaper

    Intestinal Disaccharidase Deficiency in Adults: Evaluation and Treatment

    The implications of disaccharidase deficiency as it pertains to neurogastroenterology and motility disorders has been a mystery for the past several decades. While congenital disaccharidase deficiency has been established as a cause of chronic …

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