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Herpes Simplex Type 2 

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  1. Open Access 01-12-2023 | Herpes Virus | OriginalPaper

    Seroprevalence of herpes simplex virus type 1 and type 2 among the migrant workers in Qatar

    Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections are life-long and common worldwide [ 1 ]. Infections with these viruses are typically latent and asymptomatic, but with frequent reactivations, subclinical shedding and sporadic …

  2. Open Access 01-03-2022 | Herpes Virus | OriginalPaper

    Management of herpesvirus reactivations in patients with solid tumours and hematologic malignancies: update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) on herpes simplex virus type 1, herpes simplex virus type 2, and varicella zoster virus

    Clinical reactivations of herpes simplex virus or varicella zoster virus occur frequently among patients with malignancies and manifest particularly as herpes simplex stomatitis in patients with acute leukaemia treated with intensive chemotherapy …

  3. Open Access 01-12-2022 | Herpes Virus | OriginalPaper

    Prevalence and correlates of Kaposi’s sarcoma-associated herpesvirus and herpes simplex virus type 2 infections among adults: evidence from the NHANES III data

    Kaposi’s sarcoma-associated herpes virus (KSHV) also referred as human herpesvirus-8 (HHV-8), is the etiologic agent for the occurrence of Kaposi's sarcoma (KS), Primary effusion lymphoma (PEL) and Multicentric Castleman's disease (MCD) [ 1 – 3 ].

  4. Open Access 01-12-2022 | Herpes Virus | OriginalPaper

    Upregulation of nuclear factor E2-related factor 2 (Nrf2) represses the replication of herpes simplex virus type 1

    Herpes Simplex Virus type 1 (HSV-1) is a prevalent and important human pathogen with a worldwide seroprevalence of more than 80% in adults. Despite considerable effort, there is still no cure and no vaccine for HSV-1 [ 1 ]. Oxidative stress-induced …

  5. 01-06-2020 | Primary Immunodeficiency | OriginalPaper

    Herpes simplex virus type 2 meningitis as a manifestation of Good’s syndrome

    Good’s syndrome is a primary immunodeficiency phenocopy characterized for thymoma and immunodeficiency. The most frequent clinical presentation is recurrent or opportunistic infections, hematological alterations, and chronic diarrhea. We treated a …

  6. Open Access 01-12-2019 | Herpes Virus | OriginalPaper

    Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement

    Herpes simplex virus (HSV) is a large, double-stranded DNA virus belonging to the ubiquitous Herpesviridae family of viruses, which includes the herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), varicella zoster virus …

  7. 01-10-2020 | Herpes Virus | OriginalPaper

    Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging

    Reporter gene-based molecular imaging, including positron emission tomography (PET) with the appropriate reporter probes, is a noninvasive and quantitative imaging tool for monitoring specific biological process, investigating protein-protein …

  8. Open Access 01-12-2018 | OriginalPaper

    SERO-prevalence of herpes simplex virus type 1 and type 2 among women attending routine Cervicare clinics in Ghana

    Herpes simplex virus (HSV) has been characterized into two distinct serotypes: HSV -1 and HSV -2 [ 1 ]. HSV type 1 has been associated with orofacial infections and HSV type 2 with genital infections. Clinical reports citing an increasing number of …

  9. Open Access 01-12-2018 | OriginalPaper

    Herpes simplex virus type 2 infection triggers AP-1 transcription activity through TLR4 signaling in genital epithelial cells

    Herpes simplex virus type 2 (HSV-2), a member of herpesviridae family, is one of the most prevalent human pathogens in the world, which causes genital herpes and can be transmitted to central nervous system (CNS) to establish lifelong infection [ 1 …]. HSV-2 is primarily transmitted through sexual contact and is common among persons infected with HIV-1 [

  10. Open Access 01-12-2017 | OriginalPaper

    Rubella, herpes simplex virus type 2 and preeclampsia

    Preeclampsia is defined by hypertension and proteinuria that occur in the second half of pregnancy. It may be a symptomless, however various signs and symptoms e.g. edema, visual disturbances, headache, and epigastric pain may be observed …

  11. Open Access 01-12-2017 | OriginalPaper

    Seropositivity to herpes simplex virus type 2, but not type 1 is associated with cervical cancer: NHANES (1999–2014)

    Cervical cancer represents the fourth most common cancer among women globally: It accounts for 7.9% of total cancer cases in females. 528,000 newly occurred cases and 266,000 deaths were estimated in 2012 [ 1 , 2 ]. In the United States, the …

  12. Open Access 01-12-2017 | Erratum

    Erratum to: Precision of the Kalon Herpes Simplex Virus Type 2 IgG ELISA: an international inter-laboratory assessment

    After the publication of this work [ 1 ] it was noticed that the 11 th author, Barry Kosloff, was omitted from the author list.

  13. Open Access 01-12-2017 | OriginalPaper

    Seroprevalence of Herpes Simplex Virus type-2 (HSV-2) among pregnant women who participated in a national HIV surveillance activity in Haiti

    Herpes simplex virus type 2 (HSV-2), the primary cause of genital herpes, is one the most common causes of genital ulcers [ 1 , 2 ]. HSV-2 can be contracted during pregnancy and can be transmitted to the fetus or newborn, sometimes with devastating …

  14. Open Access 01-12-2017 | OriginalPaper

    Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control

    Herpes simplex virus is the main cause of genital ulcers worldwide [ 1 ]. Both Herpes simplex virus 1 (HSV1) and Herpes simplex virus 2 (HSV2) infect the epithelial cells of the skin and mucosa through minor breaks, and then travel by retrograde …

  15. 01-10-2017 | OriginalPaper

    Regulation of T-type Ca2+ channel expression by herpes simplex virus-1 infection in sensory-like ND7 cells

    Infection of sensory neurons by herpes simplex virus (HSV)-1 disrupts electrical excitability, altering pain sensory transmission. Because of their low threshold for activation, functional expression of T-type Ca2+ channels regulates various cell …

  16. 01-05-2017 | OriginalPaper

    Local and Systemic Functional Responses of Mouse Macrophages to Intravaginal Infection with Type 2 Herpes Simplex Virus and Vaccination

    Activity of cathepsin D and phagocytosis of macrophages from vaginal lavage fluid, peritoneal exudation, and spleen were studied in mice of sensitive (DBA/2) and resistant (BALB/c) lines after intravaginal infection with type 2 herpes simplex

  17. 01-12-2016 | Report

    Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro

    Ficus religiosa extracts have been used in traditional Indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. The aim of this study was to investigate the antiviral activity of F. religiosa extracts against …

  18. Open Access 01-12-2016 | OriginalPaper

    Herpes simplex virus type 1 and type 2 in the Netherlands: seroprevalence, risk factors and changes during a 12-year period

    Herpes Simplex Virus (HSV) can cause orolabial and genital infections. Most HSV infections are asymptomatic, but when symptoms occur, they consist primarily of ulcerative lesions at the site of infection. HSV infections remain lifelong and are …

  19. 01-04-2016 | OriginalPaper

    Multiple strokes associated with herpes simplex virus type-2 infection: case report

    Herpes simplex virus (HSV) type-2 is known to cause meningitis and usually runs a benign course. Association of such infection with vasculitis of the central nervous system is not well known. Presented here is a case initially diagnosed as aseptic …

  20. 01-08-1997 | OriginalPaper

    Characterization of T cell responses to herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) using a TNF-β ELISpot cytokine assay

    We examined the suitability of a TNF-β cytokine ELISpot assay for assessing various aspects of the T cell response to herpes simplex viruses. The number of T cells responding to HSV-1 or HSV-2 was measured by TNF-β ELISpot assay. The number of T …

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