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1289 search results for:

Gestational Trophoblastic Disease 

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  1. 01-03-2023 | Gestational Trophoblastic Disease | ReviewPaper

    Immune checkpoint inhibitor using in cases with gestational trophoblastic diseases

    Gestational trophoblastic neoplasias (GTNs) are chemosensitive disorders with very high cure rates. However, individuals with chemoresistant diseases pass away as a result of their illness, necessitating the use of innovative medications. Immune …

  2. 24-08-2022 | Infertility | OriginalPaper

    Association of extended culture to blastocyst and pre-malignant gestational trophoblastic disease risk following IVF/ICSI-assisted reproduction cycles: an analysis of large UK national database

    Gestational trophoblastic disease (GTD) spans a disease spectrum from premalignant conditions such as partial and complete hydatidiform molar pregnancy (commonly referred to as hydatidiform moles) through to malignant conditions such as invasive …

  3. Open Access 01-12-2021 | Gestational Trophoblastic Disease | OriginalPaper

    Does hysteroscopy in women with persistent gestational trophoblastic disease reduce the need for chemotherapy? A prospective, single-arm, clinical trial pilot study

    Hydatidiform mole [ 1 ] also known as molar pregnancy occurs by placental pathology of androgenetic origin [ 2 ]. This phenomenon happens with abnormal hyperproliferation of the placental villi and hydropic degeneration [ 3 ]. HM belongs to the …

  4. 10-02-2023 | Magnetic Resonance Imaging | ReviewPaper

    Gestational trophoblastic disease: an update

    Gestational trophoblastic diseases (GTD) encompass a spectrum of rare pre-malignant and malignant entities originating from trophoblastic tissue. This updated review will highlight important radiological features, pathology and classification, and …

  5. Open Access 01-12-2022 | Infertility | OriginalPaper

    Association between gestational trophoblastic disease (GTD) history and clinical outcomes in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles

    Gestational trophoblastic disease (GTD) covers a range of premalignant and malignant pregnancy-related disorders associated with highly abnormal placental trophoblastic tissue [ 1 ]. GTD includes 5 histological types: hydatidiform mole, erosive …

  6. Open Access 01-12-2021 | Gestational Trophoblastic Disease | ReviewPaper

    Hyperthyroidism in gestational trophoblastic disease – a literature review

    Gestational trophoblastic disease (GTD) is the umbrella term for a heterogenous group of pregnancy-related disorders arising from abnormal proliferation of placental trophoblast. GTD encompasses the premalignant condition of hydatidiform mole …

  7. Open Access 01-12-2019 | Gestational Trophoblastic Disease | OriginalPaper

    Spontaneous regression of quiescent gestational trophoblastic disease after pregnancy: a case report

    In recent decades, quiescent gestational trophoblastic disease (Q-GTD) has been defined as an inactive or benign form of GTD without detectable lesions that is diagnosed by a persistent low-level elevation of the serum human chorionic gonadotropin …

  8. 01-01-2004 | OriginalPaper

    Successful salvage therapy of resistant gestational trophoblastic disease with etoposide, methotrexate, actinomycin-d, etoposide, cisplatin (EMA/EP)

    A 26-year-old woman who had been treated for nonmetastatic gestational trophoblastic tumor with three courses of methotrexate with folinic acid rescue and had been lost to follow up for 4 years was referred with the fractional curettage diagnosis …

  9. Open Access 01-01-2018 | OriginalPaper

    SEOM clinical guidelines in gestational trophoblastic disease (2017)

    Gestational trophoblastic disease (GTD) is a rare but curable disease. Recent improvements in diagnosis and molecular biology have resulted in changes in staging and treatment. These guidelines provide evidence-based recommendation on how to …

  10. 01-04-2000 | OriginalPaper

    Gestational Trophoblastic Disease

    Patients diagnosed with molar pregnancy are treated by either suction curettage or hysterectomy, depending on their desire to preserve fertility. We use single-agent chemotherapy, preferably methotrexate, to treat low- or moderate-risk persistent …

  11. 01-03-2014 | ReviewPaper

    Management Options of Gestational Trophoblastic Disease

    During the past year, studies have advanced the understanding and management of gestational trophoblastic diseases. Molar pregnancy is now diagnosed earlier in gestation across the globe due to increasingly availability of hCG measurement and …

  12. 01-03-2014 | ReviewPaper

    Clinical Epidemiology of Gestational Trophoblastic Disease

    The epidemiology of gestational trophoblastic disease (GTD) is not well defined. The rarity of the disease and challenges in data collection limit interpretation of incidence data. Incidence of GTD appears to be influenced by geographic region …

  13. 01-03-2014 | ReviewPaper

    Classification and Morphology of Gestational Trophoblastic Disease

    Gestational trophoblastic disease (GTD) is a clinically and morphologically very heterogeneous group of interrelated lesions, characterised by abnormal growth of the different types of trophoblastic cells, sometimes associated with villous …

  14. Open Access 01-03-2014 | ReviewPaper

    Management of Chemoresistant and Quiescent Gestational Trophoblastic Disease

    Gestational trophoblastic neoplasia (GTN) is highly chemosensitive and has a high cure rate. Since the introduction of chemotherapy, reliable measurement of human chorionic gonadotropin (hCG) levels, and individualised risk-based therapy into the …

  15. 01-04-2007 | BriefCommunication

    Gestational trophoblastic disease following in vitro fertilization

    Gestational trophoblastic disease (GTD) is a spectrum of disorders, ranging from hydatidiform mole to choriocarcinoma and placental site tumor, its etiology remains uncertain [ 1 ]. We report two cases that were accepted on the in vitro …

  16. 01-03-1997 | OriginalPaper

    Expression of epidermal growth factor receptor in gestational trophoblastic diseases

    Gestational trophoblastic disease in an abnormal condition of the placenta, the incidence of which is very high in the State of Kerala, India. The biology of this disease is vague and methods to determine the malignant potential are limited.

  17. 01-05-2007 | OriginalPaper

    False-positive β-human chorionic gonadotropin values in the follow-up of gestational trophoblastic disease

    Gestational trophoblastic disease consists of a pathological spectrum of entities from molar pregnancies, which are premalignant conditions, to malignant invasive choriocarcinoma. Serum β-human chorionic gonadotropin (hCG) levels are essential …

  18. 01-04-2011 | OriginalPaper

    May platelet count be a predictor of low-risk persistent gestational trophoblastic disease?

    Gestational trophoblastic disease consists of a wide spectrum of cellular proliferation ranging from hydatidiform mole (complete and partial), invasive mole, and choriocarcinoma to placental site trophoblastic tumor. The reported frequency of …

  19. 01-06-2007 | OriginalPaper

    P57kip2 immunohistochemical expression and ultrastructural findings of gestational trophoblastic disease and related disorders

    Gestational trophoblastic disease (GTD) is a unique spectrum of diseases ranging from complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and invasive mole (IM) to choriocarcinoma (CC). Placental site trophoblastic tumor (PSTT) and …

  20. 01-03-2009 | OriginalPaper

    Investigation of Soluble HER2 and Transforming Growth Factor Beta-1 Serum Levels in Gestational Trophoblastic Disease

    HER2/neu and TGF-β1 are over-expressed in various types of malignancies. It appears that they play an important role in the biologic behavior of tumors and have prognostic value. Gestational tropoblastic diseases (GTDs) comprise of a heterogeneous …

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