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5721 search results for:

Beta-Lactam-Antibiotics 

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  1. 08-05-2024 | Antibiotic | Online First

    Failure of target attainment for beta-lactam antibiotics and ciprofloxacin in acute brain-injured intensive care patients

  2. 20-04-2024 | Antibiotic | Online First

    Delabeling of allergy to beta-lactam antibiotics in hospitalized patients: a prospective study evaluating cost savings

    Beta-lactam allergy label affects a significant percentage of the population (approximately 10% of the US population) and implies the use of alternative antibiotics associated with higher mortality and healthcare costs. Delabeling beta-lactam

  3. 12-11-2021 | Antibiotic | ReviewPaper

    Immediate and Delayed Hypersensitivity Reactions to Beta-Lactam Antibiotics

    Beta-lactam antibiotics are the most commonly reported drug allergy in adults and children. More than 95% of those with reported allergy labels to beta lactams are not confirmed when subjected to allergy testing. Beta lactam antibiotics are …

  4. Open Access 09-11-2022 | Ciprofloxacin | OriginalPaper

    Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial

    Timely and appropriate antibiotic treatment is vital in treating critically ill patients [ 1 , 2 ]. Beta-lactam antibiotics and fluoroquinolones are among the most prescribed antibiotics in the intensive care unit (ICU) [ 3 , 4 ]. The …

  5. Open Access 01-12-2020 | Pharmacokinetics | OriginalPaper

    Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)

    Less than two-thirds of our study population achieved the 100% ƒT > MIC ECOFF target, and only in one-third the 100% ƒT > 4×MIC ECOFF target was achieved. Male gender, high BMI, and eGFR ≥ 90 mL/min/1.73 m 2 were significantly associated with …

  6. Open Access 01-12-2019 | Pharmacokinetics | ReviewPaper

    Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)

    The use of antibiotics in the critical care setting is very common. A large multicenter European study reported antibiotic use in 64% of patients during their stay in the intensive care unit (ICU) [ 1 ]. In France, nearly half of ICU patients are …

  7. 01-03-2018 | ReviewPaper

    Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections?

    Antibiotics are among the medications most frequently administered to the critically ill, a population with high levels of intra- and inter-individual pharmacokinetic variability. Our knowledge of the relationships among antibiotic dosing …

  8. 01-01-2019 | OriginalPaper

    Inoculum effect of methicillin-susceptible Staphylococcus aureus against broad-spectrum beta-lactam antibiotics

    Scarce information concerning the inoculum effect (InE) of methicillin-susceptible Staphylococcus aureus (MSSA) against broad-spectrum β-lactam antibiotics is available. We investigated the InE of MSSA against ceftriaxone, cefepime, meropenem …

  9. Open Access 01-12-2018 | ReviewPaper

    Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients

    Antimicrobials are among the most important and commonly prescribed drugs in the management of critically ill patients and beta-lactams are the most common antibiotic class used. Critically ill patient’s pathophysiological factors lead to altered …

  10. 01-05-2018 | ReviewPaper

    Pharmacokinetic/Pharmacodynamic Considerations of Beta-Lactam Antibiotics in Adult Critically Ill Patients

    Beta-lactam antibiotics (penicillins, cephalosporins, and carbapenems) are routinely used to treat serious infections in critically ill patients managed in the intensive care unit (ICU). All beta-lactams exhibit time-dependent bactericidal …

  11. Open Access 01-09-2018 | OriginalPaper

    Benzylpenicillin versus wide-spectrum beta-lactam antibiotics as empirical treatment of Haemophilus influenzae-associated lower respiratory tract infections in adults; a retrospective propensity score-matched study

    There is consensus that definitive therapy for infections with H. influenzae should include antimicrobial agents with clinical breakpoints against the bacterium. In Scandinavia, benzylpenicillin is the recommended empirical treatment for …

  12. 01-06-2003 | OriginalPaper

    Hypersensitivity reactions to beta-lactam antibiotics

    Clinicians commonly encounter patients with a history of allergy to penicillin and other beta-lactam antibiotics, since about 10% of the population reports such an allergy. At the same time, it is known that about 90% of these patients are not …

  13. 01-06-2003 | OriginalPaper

    Hypersensitivity reactions to non-beta-lactam antibiotics

    As alternatives to beta lactam antibiotics continue to be developed, an increasing number of patients are experiencing hypersensitivity reactions to these agents. Unfortunately, unlike penicillin, there are no validated skin testing reagents to …

  14. 01-06-2016 | OriginalPaper

    Impact of de-escalation of beta-lactam antibiotics on the emergence of antibiotic resistance in ICU patients: a retrospective observational study

    Selection of the appropriate antimicrobial therapy for critically ill patients is challenging in the context of the increasing prevalence of antimicrobial resistance. International and local guidelines advocate the use of broad-spectrum …

  15. 01-09-1997 | OriginalPaper

    Bactericidal activity of 5 beta-lactam antibiotics againstStreptococcus pneumoniae

    Assays were performed to determine bactericidal activity as a function of time (1, 3, 5, and 7 hours) and of the concentration (1, 2, 4, and 8 MIC) of antibiotics for 2 penicillin-sensitive strains ofStreptococcus pneumoniae (MIC<0.06 mg/L), 2 …

  16. Open Access 01-07-2014 | Abstract

    Multiple drug hypersensitivity to beta lactam and non beta lactam antibiotics, inhibitors of conversion enzyme, thiopental and COX2 inhibitors on a hyperthyroid male patient - case report

    The multiple drug hypersensitivity is an rare syndrome, severe as presentation, evolution and therapeutic approach as well as for the patient, as for the allergist. It includes a panoramic approach of the clinical already assessed reactions …

  17. 01-12-1997 | OriginalPaper

    Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention

    The nephrotoxic beta-lactam antibiotics cause acute proximal tubular necrosis. Significant renal toxicity, which has been rare with the penicillins and uncommon with the cephalosporins, is a greater risk with the penems. Mechanisms of injury …

  18. 01-10-2005 | ReviewPaper

    Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside

    Central nervous system toxicity following administration of beta-lactam antibiotics, of which penicillin is the prototype, is a potential cause of morbidity and mortality. In recent years, important advances have been made in the pathogenesis of …

  19. 01-10-2010 | Letter

    Beta-lactam antibiotics in continuous infusion in critically ill patients

    Fabio Silvio Taccone, Jean-Louis Vincent and Frédérique Jacobs …

  20. 01-08-2011 | OriginalPaper

    In vitro activity of beta-lactam antibiotics against CTX-M-producing Escherichia coli

    Beta-lactam antibiotics have been discussed as options for the treatment of infections caused by multiresistant extended-spectrum beta-lactamase (ESBL)-producing bacteria if the minimum inhibitory concentration (MIC) is low. The objective of this …

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