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  1. Open Access 01-12-2024 | Lung Cancer | OriginalPaper

    circNINL facilitates aerobic glycolysis, proliferation, invasion, and migration in lung cancer by sponging miR-3918 to mediate FGFR1 expression

    Previously characterized as an oncogenic player in breast cancer, the function of circular RNA NINL (circNINL) in lung cancer (LC) remained elusive. This study aimed to delineate the biological role of circNINL in LC and to unveil its potential …

  2. 01-12-2023 | Malnutrition | OriginalPaper

    Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer

    Gastric cancer (GC) is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. According to statistics, GC was responsible for over one million new cases and 700,000 deaths in 2020 [ 1 ]. Patients with …

  3. Open Access 01-12-2021 | Myocardial Infarction | OriginalPaper

    Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in Irish Caucasian patients with diabetes: a report from the STOP-HF follow-up programme

    The growth of cardiovascular disease in diabetes, including hypertension, myocardial infarction and diabetes-related cardiomyopathy, is a persistent global public health problem [ 1 , 2 ]. In particular, heart failure risk remains high in type 2 …

  4. 01-12-2023 | Cholangitis | Letter

    Letter to the Editor: Comment on Wickramasekara N, Ignatius J, Lamahewage A. Prognostic factors and outcomes of Kasai portoenterostomy (KPE): nine-year experience from a lower-middle income country. Pediatr Surg Int. 2023; 39(1):142. doi: 10.1007/s00383-023–05,424-y

    We read with interest the report by Wickramasekara et al. on their experience in managing infants with biliary atresia in a large referral hospital in Sri Lanka during a recent 6-year period [ 1 ]. The core group was stated as 79 though with lots …

  5. Open Access 01-12-2022 | Eclampsia | OriginalPaper

    Hypertensive disorders in pregnancy complicated by liver rupture or hematoma: a systematic review of 391 reported cases

    A spontaneous hepatic rupture in pregnancy/puerperium (SHRP) is often an unrecognized, extremely rare life-threatening condition primarily associated with preeclampsia, eclampsia, or HELLP (hemolysis, elevated liver enzymes, and low platelet …

  6. 17-05-2022 | Acute Myeloid Leukemia | OriginalPaper

    A phase Ib dose escalation study of oral monotherapy with KX2-391 in elderly patients with acute myeloid leukemia

    Poor tolerance to standard therapies and multi-drug resistance complicate treatment of elderly patients with acute myeloid leukemia (AML). It is therefore imperative to explore novel tolerable agents and target alternative pathways. KX2-391 is an …

  7. 01-06-2022 | Insomnia

    COVID-19 Lockdowns: A Worldwide Survey of Circadian Rhythms and Sleep Quality in 3911 Athletes from 49 Countries, with Data-Driven Recommendations

    The severe acute respiratory syndrome coronavirus 2-mediated coronavirus disease 2019 (COVID-19) pandemic enforced global change upon day-to-day life [ 1 ]. Most nations responded with one or more periods of localised or country-wide lockdowns …

  8. 01-09-2021 | Paget's Disease of Bone | OriginalPaper

    Decreasing severity of Paget’s disease of bone in northern Italy over the last two decades: results of a monocentric study on 391 patients

    Paget’s disease of bone (PDB) is a focal disorder of bone remodelling of unknown aetiology which may lead to bone pain, secondary osteoarthritis, bone deformity, fractures, and other less frequent clinical manifestations such as hearing loss …

  9. Open Access 01-03-2013 | OriginalPaper

    Association between endothelial NO synthase polymorphism (rs3918226) and arterial properties

  10. 01-10-2017 | OriginalPaper

    MiR-3910 Promotes the Growth and Migration of Cancer Cells in the Progression of Hepatocellular Carcinoma

    Hepatocellular carcinoma (HCC) is one of the most common malignancies in the word [ 1 , 2 ], especially in China due to the prevalence of hepatitis B virus (HBV) [ 3 ]. Although the molecular-target therapeutic strategy has been developed, the …

  11. 01-11-2015 | OriginalPaper

    The rs3917779 polymorphism of P-selectin’s significant association with proliferative diabetic retinopathy in Yazd, Iran

    Diabetes mellitus type II affects many people worldwide and diabetic retinopathy (DR), the major cause of blindness amongst middle-aged people, is one of its most important clinical complications [ 1 ]. DR is a kind of retinal damage and usually …

  12. 01-12-2000 | OriginalPaper

    Population genetics of the hypervariable locus D12S391 in Koreans

    The hypervariable short tandem repeat (STR) locus D12S391 was investigated in a Korean population and 34 fragments were sequenced to confirm the structure of alleles. From these sequenced fragments an allelic ladder containing 13 sequenced alleles …

  13. 01-08-1999 | OriginalPaper

    Modified primers for D12S391 and a modified silver staining technique

    In this paper we describe a new primer pair for the short tandem repeat (STR) D12S391 which makes it possible to obtain considerably shorter amplification fragments (125–173 bp), compared to the previously published primers (205–253 bp). The …

  14. 01-07-2002 | Announcement

    Is the laparoscopic approach appropriate for appendicitis? An audit of 391 consecutive cases

    We would advocate a policy of laparoscopy for all suspected cases of acute appendicitis. Hospital stay and complication rates following CA are similar to that of OA. Additionally, open surgery mandates appendicectomy, which may be avoided at …

  15. 01-02-2001 | OriginalPaper

    Preclinical pharmacology of CP-424,391, and orally active pyrazolinone-piperidine growth hormone secretagogue

    Growth hormone secretagogues (GHSs) represent attractive therapeutic alternatives to recombinant growth hormone (GH), given their ability to amplify pulsatile hormone secretion in a relatively physiologic manner. CP-424,391 (391) is a novel …

  16. 01-12-1998 | OriginalPaper

    Validation studies and characterization of variant alleles at the short tandem repeat locus D12S391

    Validation studies were carried out on the short tandem repeat (STR) locus D12S391 including the determination of the allele frequencies, forensic application and sequence analysis of variant alleles. A total of 16 alleles were found in a …

  17. 01-02-2000 | OriginalPaper

    Further sequence and length variation at the STR loci HumFES/FPS, HumVWA, HumFGA and D12S391

    This paper reports population data and statistics for the HumFES/FPS, HumVWA, HumFGA and D12S391 loci in Austria. The sequences of some rare and new variant alleles which have been identified in the course of the present population study and other …

  18. Open Access 01-10-2010 | OriginalPaper

    Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units

    Administration of intravenous fluid is one of the most common interventions in the management of patients in intensive care units (ICUs). Despite this, there is limited high quality information to guide clinicians in deciding when fluid …

  19. 01-12-1997 | OriginalPaper

    Population genetics of the D12S391, CSF1PO and TPOX loci in Catalonia (Northeast Spain)

    Allele and genotype frequencies for three short tandem repeat loci were determined in a population sample from Catalonia (NE Spain). After denaturing PAGE electrophoresis, 11 alleles were identified for D12S391 (n = 167), 9 alleles for CSF1pO (n = …

  20. 01-12-2002 | OriginalPaper

    Point mutations in the flanking regions of the Y-chromosome specific STRs DYS391, DYS437 and DYS438

    Sequence analysis of the DNA fragments amplified with the DYS391, DYS437 and DYS438 primers allowed the detection of biallelic polymorphisms in the flanking region of these STR loci. In this work, we describe a methodology where both the STR …

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