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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 6/2007

01-12-2007 | Review

Toll-like receptors and innate immune responses in systemic lupus erythematosus

Authors: Robert Lafyatis, Ann Marshak-Rothstein

Published in: Arthritis Research & Therapy | Issue 6/2007

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Abstract

A series of discoveries over the past several years has provided a new paradigm for understanding autoimmunity in systemic lupus erythematosus. The discoveries of pattern recognition receptors and of how these receptors can be recruited into autoimmune responses underpin this paradigm. The implications of these observations continue to unfold with ongoing investigation into the range and specificity of pattern recognition receptors, into how immune complexes containing nucleic acids trigger these receptors, into how endogenous macromolecular 'danger signals' stimulate innate immune responses, and into the effect of pattern recognition receptor activation on various cell types in initiating and perpetuating autoimmunity. The development of clinical trials using therapeutic agents that target components of the innate immune system suggests that these advances may soon culminate in new medications for treating patients with systemic lupus erythematosus.
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Metadata
Title
Toll-like receptors and innate immune responses in systemic lupus erythematosus
Authors
Robert Lafyatis
Ann Marshak-Rothstein
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 6/2007
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2321

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