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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 2/2014

Open Access 01-12-2014 | Meeting abstract

Tobacco smoke induces changes in IL-1 family in bronchial epithelial cells obtained from asthmatic individuals

Authors: Valérie Gagné-Ouellet, Éric Jacques, Anne-Marie Boucher-Lafleur, Sophie Plante, Luigi Bouchard, Jamila Chakir, Catherine Laprise

Published in: Allergy, Asthma & Clinical Immunology | Special Issue 2/2014

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Excerpt

Exposure to tobacco smoke (ETS) induces epigenetic modifications including DNA methylation [1]. In asthma, it has been shown that those modifications affect immune cell differentiation by downregulating expression of specific pro-inflammatory cytokines [2‐4]. Interleukin 1 (IL-1) is recognized to be increased in asthma [5] and by cigarette smoke [5, 6]. Based on previous genetic association [7, 8] and DNA methylation signature of receptors in asthma and/or atopy the aim of this study is to evaluate the changes in expression and methylation pattern induced by ETS for IL-1 subunit alpha (IL-1A) and beta (IL-1B), receptors type I (IL-1R1), type II (IL-1R2) and antagonist (IL-1RA) and for interleukin 33 (IL-33) in lung tissue. …
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Metadata
Title
Tobacco smoke induces changes in IL-1 family in bronchial epithelial cells obtained from asthmatic individuals
Authors
Valérie Gagné-Ouellet
Éric Jacques
Anne-Marie Boucher-Lafleur
Sophie Plante
Luigi Bouchard
Jamila Chakir
Catherine Laprise
Publication date
01-12-2014
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1710-1492-10-S2-A55

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