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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 7/2005

01-07-2005 | Review Article

To use MIBI or not to use MIBI? That is the question when assessing tumour cells

Authors: Jean-Luc Moretti, Nathalie Hauet, Meltem Caglar, Olivier Rebillard, Zeynep Burak

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 7/2005

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Abstract

99mTc-sestamibi (MIBI) is a well-known tumour imaging agent. Its retention within tumour cell mitochondria is related to perfusion and to the magnitude of the electrical gradient, reflecting cell viability. Several internal cell factors modulate this uptake; for example, multidrug resistance membrane proteins (Pgp and MRP1) and anti-apoptotic BCl-2 protein of the outer mitochondrial membrane can limit retention of MIBI. At the early stage of cell apoptosis, the electrical driving forces of MIBI uptake are impaired, and influx and accumulation are reduced. It seems clear that MIBI can be used before treatment to detect drug resistance, assess anti-apoptotic status and predict treatment efficacy. Although it has been suggested that MIBI might be used to monitor tumour response to treatment, MIBI is unable to differentiate tumours with ongoing apoptosis from those developing drug resistance.
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Metadata
Title
To use MIBI or not to use MIBI? That is the question when assessing tumour cells
Authors
Jean-Luc Moretti
Nathalie Hauet
Meltem Caglar
Olivier Rebillard
Zeynep Burak
Publication date
01-07-2005
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 7/2005
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-005-1840-x

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