Published in:
01-04-2016 | Editorial
Tired of Hepatitis B?
Authors:
Kavish R. Patidar, Jasmohan S. Bajaj
Published in:
Digestive Diseases and Sciences
|
Issue 4/2016
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Excerpt
Fatigue is a symptom complex encompassing that is often reported as malaise, exhaustion, and lethargy, with a reported prevalence of 25 % in the overall population [
1]. While some fatigue is to be expected as a consequence of daily activities (i.e., exercise, work, activities of daily living), it is also an important patient-reported outcome in chronic diseases. Fatigue can be either central or peripheral (or both) in etiology [
2]. Peripheral fatigue is a result of neuromuscular dysfunction, which often manifests clinically as weakness in patients with advanced liver disease, whereas central fatigue is often associated with neuropsychiatric problems (i.e., depression and anxiety) and sleep issues. Central fatigue often manifests as difficulty in performing physical and mental activities that require self-motivation and internal signals. …
