Published in:
Open Access
01-12-2014 | Meeting abstract
Tiotropium respimat® add-on therapy reduces airflow obstruction in patients with symptomatic moderate asthma, independent of TH2 inflammatory status
Authors:
WH Yang, T Casale, ED Bateman, R Dahl, E Pizzichini, M Vandewalker, JC Virchow, M Engel, PM Moroni-Zentgraf, H Schmidt, HAM Kerstjens
Published in:
Allergy, Asthma & Clinical Immunology
|
Special Issue 2/2014
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Excerpt
In patients with symptomatic asthma receiving ICS or ICS+LABA, Phase III studies have demonstrated improved lung function with tiotropium Respimat®, a once-daily long-acting anticholinergic bronchodilator. The efficacy of some treatments (eg ICS and omalizumab), appears higher in TH2-high phenotypes, but no specific treatments are available that work equally well in both TH2-high and TH2-low phenotypes. We explored whether TH2 biomarker status influenced responses to tiotropium in patients with moderate symptomatic asthma. …