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Allergy, Asthma & Clinical Immunology
Published in: Allergy, Asthma & Clinical Immunology 2/2014

Open Access 01-12-2014 | Meeting abstract

Treatment of angiotensin-converting enzyme inhibitor related angioedema with icatibant

Authors: Peter Ho, Chrystyna Kalicinsky

Published in: Allergy, Asthma & Clinical Immunology | Special Issue 2/2014

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Excerpt

The absolute risk of angiotensin-converting enzyme (ACE) inhibitor angioedema is 0.3% [1]. The mechanism is felt to be accumulation of bradykinin. The current treatment is discontinuation of ACE-I inhibitor, and intubation if necessary. Icatibant is a bradykinin receptor antagonist, useful in treating hereditary angioedema [2]. We present a patient from a Canadian center who had ACE-inhibitor induced angioedema requiring intubation who did not respond to epinephrine or C1 esterase inhibitor concentrate, then later responded favorably to Icatibant. …
Literature
1.
Makani H, M F-P: Meta-analysis of randomized trials of angioedema as an adverse event of renin-angiotensin system inhibitors. American Journal of Cardiology,. 2010, 110 (3): 383-91.CrossRef
2.
3.
Bas M, G J: Therapeutic Efficacy of Icatibant in Angioedema Induced by Angiotensin-Converting Enzyme Inhibitors: A Case Series. Annual Emergency Medicine. 2010, 56 (3): 278-82. 10.1016/j.annemergmed.2010.03.032.CrossRef
Metadata
Title
Treatment of angiotensin-converting enzyme inhibitor related angioedema with icatibant
Authors
Peter Ho
Chrystyna Kalicinsky
Publication date
01-12-2014
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1710-1492-10-S2-A18

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