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Open Access 01-12-2006 | Research

Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy

Authors: Juan J Grau, Ramon Palmero, Maribel Marmol, Jose Domingo-Domenech, Mariano Monzo, Jose Fuster, Oscar Vidal, Constantino Fondevila, Juan C Garcia-Valdecasas

Published in: World Journal of Surgical Oncology | Issue 1/2006

Abstract

Background

We investigated the change of prognosis in resected gastric cancer (RGC) patients and the role of radical surgery and adjuvant chemotherapy.

Methods

We retrospectively analyze the outcome of 426 consecutive patients from 1975 to 2002, divided into 2 time-periods (TP) cohort: Before 1990 (TP1, n = 207) and 1990 or after (TP2; n= 219). Partial gastrectomy and D1-lymphadenetomy was predominant in TP1 and total gastrectomy with D2-lymphadenectomy it was in TP2. Adjuvant chemotherapy consisted of mitomycin C (MMC), 10–20 mg/m2 iv 4 courses or MMC plus Tegafur 500 mg/m2 for 6 months.

Results

Positive nodes were similar in TP2/TP1 patients with 56%/59% respectively. Total gastrectomy was done in 56%/45% of TP2/TP1 respectively. Two-drug adjuvant chemotherapy was administered in 65%/18% of TP2/TP1 respectively. Survival at 5 years was 66% for TP2 versus 42% for TP1 patients (p < 0.0001). Survival by stages II, IIIA y IIIB for TP2 versus TP1 patients was 70 vs. 51% (p = 0.0132); 57 vs. 22% (p = 0.0008) y 30 vs. 15% (p = 0.2315) respectively. Multivariate analysis showed that age, stage of disease and period of treatment were independent variables.

Conclusion

The global prognosis and that of some stages have improved in recent years with case RGC patients treated with surgery and adjuvant chemotherapy.

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Title: Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy
Authors: Juan J Grau
Ramon Palmero
Maribel Marmol
Jose Domingo-Domenech
Mariano Monzo
Jose Fuster
Oscar Vidal
Constantino Fondevila
Juan C Garcia-Valdecasas
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2006
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-4-53

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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