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Reviews in Endocrine and Metabolic Disorders
Published in: Reviews in Endocrine and Metabolic Disorders 4/2016

01-12-2016

Thyroid hormone regulation of adult intestinal stem cells: Implications on intestinal development and homeostasis

Authors: Guihong Sun, Julia Roediger, Yun-Bo Shi

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 4/2016

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Abstract

Organ-specific adult stem cells are essential for organ homeostasis, tissue repair and regeneration. The formation of such stem cells often takes place during postembryonic development, a period around birth in mammals when plasma thyroid hormone concentration is high. The life-long self-renewal of the intestinal epithelium has made mammalian intestine a valuable model to study the function and regulation and adult stem cells. On the other hand, much less is known about how the adult intestinal stem cells are formed during vertebrate development. Here, we will review some recent progresses on this subject, focusing mainly on the formation of the adult intestine during Xenopus metamorphosis. We will discuss the role of thyroid hormone signaling pathway in the process and potential molecular conservations between amphibians and mammals as well as the implications in organ homeostasis and human diseases.
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Metadata
Title
Thyroid hormone regulation of adult intestinal stem cells: Implications on intestinal development and homeostasis
Authors
Guihong Sun
Julia Roediger
Yun-Bo Shi
Publication date
01-12-2016
Publisher
Springer US
Published in
Reviews in Endocrine and Metabolic Disorders / Issue 4/2016
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-016-9380-1

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