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30-04-2024 | Thrombosis

Beyond silence: evolving ultrasound strategies in the battle against cardiovascular thrombotic challenges

Authors: Zhiwen Wang, Nan Jiang, Zhixin Jiang, Qing Deng, Qing Zhou, Bo Hu

Published in: Journal of Thrombosis and Thrombolysis

Abstract

Cardiovascular thrombotic events have long been a perplexing factor in clinical settings, influencing patient prognoses significantly. Ultrasound-mediated acoustic therapy, an innovative thrombolytic treatment method known for its high efficiency, non-invasiveness, safety, and convenience, has demonstrated promising potential for clinical applications and has gradually become a focal point in cardiovascular thrombotic disease research. The current challenge lies in the technical complexities of preparing ultrasound-responsive carriers with thrombus-targeting capabilities and high thrombolytic efficiency. Additionally, optimizing the corresponding acoustic treatment mode is crucial to markedly enhance the thrombolytic effectiveness of ultrasound-mediated acoustic therapy. In light of the current status, this article provides a comprehensive review of the research progress in innovative ultrasound-mediated acoustic therapy for cardiovascular thrombotic diseases. It explores the impact of technical methods, therapeutic mechanisms, and influencing factors on the thrombolytic efficiency and clinical potential of ultrasound-mediated acoustic therapy. The review places particular emphasis on identifying solutions and key considerations in addressing the challenges associated with this cutting-edge therapeutic approach.

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Title: Beyond silence: evolving ultrasound strategies in the battle against cardiovascular thrombotic challenges
Authors: Zhiwen Wang
Nan Jiang
Zhixin Jiang
Qing Deng
Qing Zhou
Bo Hu
Publication date: 30-04-2024
Publisher: Springer US
Keyword: Thrombosis
Published in: Journal of Thrombosis and Thrombolysis
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-024-02989-w

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