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Diabetologia
Published in: Diabetologia 6/2009

01-06-2009 | Letter

Thiamine in diabetic nephropathy: a novel treatment modality? Reply to Alkhalaf A, Kleefstra N, Groenier KH et al. [letter]

Authors: N. Rabbani, S. S. Alam, S. Riaz, J. R. Larkin, M. W. Akhtar, T. Shafi, P. J. Thornalley

Published in: Diabetologia | Issue 6/2009

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Excerpt

To the Editor: We thank Alkhalaf and co-authors for their comment on our recent paper in Diabetologia [1]. We are grateful for their interest in our work and the recognition of its potential importance in stimulating further research, which may lead to a significant improvement in the treatment of diabetic nephropathy. They have made several comments on issues that could not be dealt with in our short communication [2]. We now address these comments. …
Literature
1.
Alkhalaf A, Kleefstra N, Groenier KH, Bakker SJL, Navis G, Bilo HGJ (2009) Thiamine in diabetic nephropathy: a novel treatment modality? Diabetologia. doi:10.​1007/​s00125-009-1326-7
2.
Rabbani N, Alam SS, Riaz S et al (2008) High dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind, placebo-controlled pilot study. Diabetologia 52:208–212PubMedCrossRef
3.
Weber W, Kewitz H (1985) Determination of thiamine in human plasma and its pharmacokinetics. Eur J Clin Pharmacol 28:213–219PubMedCrossRef
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Ariaey-Nejad MR, Balaghi M, Baker EM, Sauberlich HE (1970) Thiamin metabolism in man. Am J Clin Nutr 23:764–778PubMed
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Babaei-Jadidi R, Karachalias N, Ahmed N, Battah S, Thornalley PJ (2003) Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes 52:2110–2120PubMedCrossRef
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Andersen S, Brochner-Mortensen J, Parving HH (2003) Kidney function during and after withdrawal of long-term irbesartan treatment in patients with type 2 diabetes and microalbuminuria. Diabetes Care 26:3296–3302PubMedCrossRef
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Chan JCN, Ko GTC, Leung DHY et al (2000) Long-term effects of angiotensin-converting enzyme inhibition and metabolic control in hypertensive type 2 diabetic patients. Kidney Int 57:590–600PubMedCrossRef
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Perkins BA, Ficociello LH, Silva KH, Finkelstein DM, Warram JH, Krolewski AS (2003) Regression of microalbuminuria in type 1 diabetes. New Engl J Med 348:2285–2293PubMedCrossRef
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American Diabetes Association (2008) Standards of medical care in diabetes—2008. Diabetes Care 31:S12–S54CrossRef
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Unnikrishnan R, Rema M, Pradeepa R et al (2007) Prevalence and risk factors of diabetic nephropathy in an urban south Indian population: the Chennai Urban Rural Epidemiology Study (CURES 45). Diabetes Care 30:2019–2024PubMedCrossRef
11.
Luk A, Chan JCN (2008) Diabetic nephropathy—what are the unmet needs? Diabetes Res Clin Pract 82:S15–S20PubMedCrossRef
Metadata
Title
Thiamine in diabetic nephropathy: a novel treatment modality? Reply to Alkhalaf A, Kleefstra N, Groenier KH et al. [letter]
Authors
N. Rabbani
S. S. Alam
S. Riaz
J. R. Larkin
M. W. Akhtar
T. Shafi
P. J. Thornalley
Publication date
01-06-2009
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 6/2009
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-009-1334-7

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