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Cardiovascular Ultrasound
Published in: Cardiovascular Ultrasound 1/2004

Open Access 01-12-2004 | Research

The use of microbubbles to target drug delivery

Authors: Jeane M Tsutsui, Feng Xie, Richard Thomas Porter

Published in: Cardiovascular Ultrasound | Issue 1/2004

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Abstract

Ultrasound-mediated microbubbles destruction has been proposed as an innovative method for noninvasive delivering of drugs and genes to different tissues. Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials. Furthermore, the ability of albumin-coated microbubbles to adhere to vascular regions with glycocalix damage or endothelial dysfunction is another possible mechanism to deliver drugs even in the absence of ultrasound. This review focuses on the characteristics of microbubbles that give them therapeutic properties and some important aspects of ultrasound parameters that are known to influence microbubble-mediated drug delivery. In addition, current studies involving this novel therapeutical application of microbubbles will be discussed.
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Metadata
Title
The use of microbubbles to target drug delivery
Authors
Jeane M Tsutsui
Feng Xie
Richard Thomas Porter
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Cardiovascular Ultrasound / Issue 1/2004
Electronic ISSN: 1476-7120
DOI
https://doi.org/10.1186/1476-7120-2-23

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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