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Clinical Oral Investigations

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01-06-2014 | Short Communication

The use of lithium as a marker for the retention of liquids in the oral cavity after rinsing

Authors: Sara M. Hanning, Jules A. Kieser, Martin M. Ferguson, Malcolm Reid, Natalie J. Medlicott

Published in: Clinical Oral Investigations | Issue 5/2014

Abstract

Objective

The aim of this study was to validate the use of lithium as a marker to indicate the retention of simple liquids in the oral cavity and use this to determine how much liquid is retained in the oral cavity following 30 s of rinsing.

Materials and methods

This is a validation study in which saliva was spiked with known concentrations of lithium. Twenty healthy participants then rinsed their mouths with either water or a 1 % w/v carboxymethylcellulose (CMC) solution for 30 s before expectorating into a collection cup. Total volume and concentration of lithium in the expectorant were then measured, and the percentage of liquid retained was calculated.

Results

The mean amount of liquid retained was 10.4 ± 4.7 % following rinsing with water and 15.3 ± 4.1 % following rinsing with 1 % w/v CMC solution. This difference was significant (p < 0.01).

Conclusions

Lithium was useful as a marker for the retention of liquids in the oral cavity, and a value for the amount of water and 1 % w/v CMC solution remaining in the oral cavity following a 30-s rinse was established.

Clinical relevance

The present study quantifies the retention of simple fluids in the oral cavity, validating a technique that may be applied to more complex fluids such as mouth rinses. Further, the application of this method to specific population groups such as those with severe xerostomia may assist in developing effective saliva substitutes.

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Title: The use of lithium as a marker for the retention of liquids in the oral cavity after rinsing
Authors: Sara M. Hanning
Jules A. Kieser
Martin M. Ferguson
Malcolm Reid
Natalie J. Medlicott
Publication date: 01-06-2014
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 5/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-013-1141-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The use of lithium as a marker for the retention of liquids in the oral cavity after rinsing

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

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