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CardioVascular and Interventional Radiology

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01-08-2013 | Clinical Investigation

The Use of Biodegradable Stents in Malignant Oesophageal Strictures for the Treatment of Dysphagia Before Neoadjuvant Treatment or Radical Radiotherapy: A Feasibility Study

Authors: Miltiadis Krokidis, Chris Burke, Stavros Spiliopoulos, Panos Gkoutzios, Orla Hynes, Irfan Ahmed, Renato Dourado, Tarun Sabharwal, Robert Mason, Andreas Adam

Published in: CardioVascular and Interventional Radiology | Issue 4/2013

Abstract

Purpose

To evaluate the clinical results of the use of biodegradable oesophageal stents in malignant strictures.

Methods

Eleven patients were included in this prospective analysis in which a woven polydioxanone biodegradable oesophageal stent was used. The inclusion criterion was that the patient underwent neoadjuvant treatment or radical radiotherapy after the stent insertion. Primary end points were dysphagia score at discharge, stent patency, and complication rate. Secondary end points were overall survival and surgical outcome of surgery.

Results

There was a 100 % procedure technical success rate. Early complications occurred in three patients resulting in failure to restore oral nutrition. In the remaining eight patients, dysphagia was significantly improved at discharge. Mean stent patency rate in this group was 71.5 days. Stent dysfunction occurred in five of eight patients (62.5 %); in two of five patients this was due to local inflammatory reaction, and in three of five patients it was due to tumour growth after a mean time of 97.8 days, and a new metallic stent was consequently placed in four of five patients. One patient was successfully treated with esophagectomy. At the end of follow-up (mean time 102.1 days), three of eight stents were patent. The overall patient survival rate was 81.8 %.

Conclusion

Although short-term dysphagia scores improved, biodegradable stents do not appear to offer a clear beneficial effect in most cases of malignant strictures, particularly due to a local inflammatory reaction that may be induced. Technical improvement of the device and delineation of the patient group that would benefit from its use is necessary if further studies are to be conducted in the future.

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Title: The Use of Biodegradable Stents in Malignant Oesophageal Strictures for the Treatment of Dysphagia Before Neoadjuvant Treatment or Radical Radiotherapy: A Feasibility Study
Authors: Miltiadis Krokidis
Chris Burke
Stavros Spiliopoulos
Panos Gkoutzios
Orla Hynes
Irfan Ahmed
Renato Dourado
Tarun Sabharwal
Robert Mason
Andreas Adam
Publication date: 01-08-2013
Publisher: Springer New York
Published in: CardioVascular and Interventional Radiology / Issue 4/2013
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-012-0503-0

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The Use of Biodegradable Stents in Malignant Oesophageal Strictures for the Treatment of Dysphagia Before Neoadjuvant Treatment or Radical Radiotherapy: A Feasibility Study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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