Top

CardioVascular and Interventional Radiology

Published in:

01-08-2013 | Case Report

Radioembolization of the Spleen: A Revisited Approach for the Treatment of Malignant Lymphomatous Splenomegaly

Authors: Kristoff Muylle, Jasmine Nguyen, Alexandre de Wind, Nathalie Meuleman, Philippe Delatte, Bruno Vanderlinden, Martine Roelandts, Anja Van der Stappen, Dominique Bron, Patrick Flamen

Published in: CardioVascular and Interventional Radiology | Issue 4/2013

Abstract

Intraarterial administration of ⁹⁰Y microspheres to the spleen in patients with malignant lymphoma was mentioned once in the literature in 1973. This case study illustrates the potential indication of selective internal radiotherapy in a heavily pretreated patient with highly refractory disease with a marginal zone lymphoma in leukemic phase and symptomatic splenomegaly. We describe the clinical course of disease; the biological and clinical response to the treatment after radioembolization; and simulation and dosimetry by multimodal imaging via single-photon emission computed tomography and computed tomography. The advantages of radioembolization for the management of lymphomatous splenomegaly are discussed.

Kennedy A, Nag S, Salem R et al (2007) Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: a consensus panel report from the radioembolization brachytherapy oncology consortium. Int J Radiat Oncol Biol Phys 68:13–23PubMedCrossRef

Gates VL, Atassi B, Lewandowski RJ et al (2007) Radioembolization with yttrium-90 microspheres: review of an emerging treatment for liver tumors. Future Oncol 3:73–81PubMedCrossRef

Lewandowski RJ, Sato KT, Atassi B et al (2007) Radioembolization with yttrium-90 microspheres: angiographic and technical considerations. Cardiovasc Intervent Radiol 30:571–592PubMedCrossRef

Swerdlow SH, Campo E, Harris NL et al (eds) (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. World Health Organization, Geneva

Bennett M, Schechter GP (2010) Treatment of splenic marginal zone lymphoma: splenectomy versus rituximab. Semin Hematol 47:143–147PubMedCrossRef

Brown JR, Friedberg JW, Feng Y et al (2009) A phase 2 study of concurrent fludarabine and rituximab for the treatment of marginal zone lymphomas. Br J Haematol 145:741–748PubMedCrossRef

Mohrbacher A (2005) B cell non-Hodgkin’s lymphoma: rituximab safety experience. Arthr Res Ther 7(Suppl 3):S19–S25CrossRef

Weber DA et al (1989) MIRD: radionuclide data and decay schemes. Society of Nuclear Medicine, New York

Ariel IM, Padula G (1973) Irradiation of the spleen by the intra-arterial administration of 90 yttrium microspheres in patients with malignant lymphoma. A preliminary rep Cancer 31:90–96

10.

Becker CD, Rösler H, Biasiutti FD, Baer HU (1995) Congestive hypersplenism: treatment by means of radioembolization of the spleen with Y-90. Radiology 195:183–186PubMed

11.

Kahl BS, Bartlett NL, Leonard JP et al (2010) Bendamustine is effective therapy in patients with rituximab-refractory, indolent B-cell non-Hodgkin lymphoma: results from a multicenter study. Cancer 116:106–114PubMed

12.

Cullingford GL, Watkins DN, Watts AD, Mallon DF (1991) Severe late postsplenectomy infection. Br J Surg 78:716–721PubMedCrossRef

13.

Maddison FE (1973) Embolic therapy of hypersplenism. Invest Radiol 8:280–281CrossRef

14.

Spigos DG, Jonasson O, Mozes M, Capek V (1979) Partial splenic embolization in the treatment of hypersplenism. Am J Roentgenol 132:777–782CrossRef

15.

Madoff DC, Denys A, Wallace MJ et al (2005) Splenic arterial interventions: anatomy, indications, technical considerations, and potential complications. Radiographics 25(Suppl 1):S191–S211PubMedCrossRef

16.

Bilbao JI, de Martino A, de Luis E et al (2009) Biocompatibility, inflammatory response, and recannalization characteristics of nonradioactive resin microspheres: histological findings. Cardiovasc Intervent Radiol 32:727–736PubMedCrossRef

Title: Radioembolization of the Spleen: A Revisited Approach for the Treatment of Malignant Lymphomatous Splenomegaly
Authors: Kristoff Muylle
Jasmine Nguyen
Alexandre de Wind
Nathalie Meuleman
Philippe Delatte
Bruno Vanderlinden
Martine Roelandts
Anja Van der Stappen
Dominique Bron
Patrick Flamen
Publication date: 01-08-2013
Publisher: Springer New York
Published in: CardioVascular and Interventional Radiology / Issue 4/2013
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-012-0484-z

At a glance: The STEP trials

Springer Medicine

Radioembolization of the Spleen: A Revisited Approach for the Treatment of Malignant Lymphomatous Splenomegaly

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2013

Does Renal Artery Supply Indicate Treatment Success of Renal Denervation?

Diagnosis and Management of Puerperal Hematomas: Two Cases

Foot Drop after Ethanol Embolization of Calf Vascular Malformation: A Lesson on Nerve Injury

Superficial Temporal Artery Cut Down to Facilitate Endovascular Treatment of External Carotid Artery Pseudoaneurysms

Below-the-ankle Angioplasty and Stenting for Limb Salvage: Anatomical Considerations and Long-term Outcomes

Bare Metal Stenting for Endovascular Exclusion of Aortic Arch Thrombi