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Published in: Clinical Neuroradiology 1/2017

01-03-2017 | Editorial

The Time–Reset Effect

Thrombectomy Trials Challenge the Existence of a Time Window

Author: Jens Fiehler

Published in: Clinical Neuroradiology | Issue 1/2017

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Excerpt

The concept of a time window suggests that a certain stroke treatment such as intravenous tissue plasminogen activator (IV tPA) or thrombectomy has a clearly defined time window between stroke (symptom) onset and initiation of therapy [1]. Therapy is expected to be futile if a patient is treated at a later time point. Usually, the time window is defined to end when the lower 95% confidence interval (CI) of the estimated treatment effect crosses 1.0 (“line of no effect”) or, simpler, according to the inclusion criteria of the particular trial. …
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Metadata
Title
The Time–Reset Effect
Thrombectomy Trials Challenge the Existence of a Time Window
Author
Jens Fiehler
Publication date
01-03-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical Neuroradiology / Issue 1/2017
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-017-0561-4

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