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Diabetologia
Published in: Diabetologia 2/2011

Open Access 01-02-2011 | Commentary

The stress of starvation: glucocorticoid restraint of beta cell development

Authors: L. C. Matthews, N. A. Hanley

Published in: Diabetologia | Issue 2/2011

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Abstract

Developmental insults during gestation, such as under-nutrition, are known to restrict the number of beta cells that form in the fetal pancreas and are maintained in adulthood, leading to increased risk of type 2 diabetes. There are now substantial data indicating that glucocorticoids mediate this effect of under-nutrition on beta cell mass and that even at physiological levels they restrain fetal beta cell development in utero. There are emerging clues that this occurs downstream of endocrine commitment by neurogenin 3 but prior to terminal beta cell differentiation. Deciphering the precise mechanism will be important as it might unveil new pathways by which to manipulate beta cell mass that could be exploited as novel therapies for patients with diabetes.
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Metadata
Title
The stress of starvation: glucocorticoid restraint of beta cell development
Authors
L. C. Matthews
N. A. Hanley
Publication date
01-02-2011
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 2/2011
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-010-1963-x

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