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Obesity Surgery
Published in: Obesity Surgery 7/2017

01-07-2017 | Brief Communication

The Sleeping Remnant. Effect of Roux-En-Y Gastric Bypass on Plasma Levels of Gastric Biomarkers in Morbidly Obese Women: A Prospective Longitudinal Study

Authors: Federico Marchesi, Francesco Tartamella, Giuseppina De Sario, Clarissa Forlini, Alberta Caleffi, Matteo Riccò, Francesco Di Mario

Published in: Obesity Surgery | Issue 7/2017

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Abstract

Background

Morpho-functional modifications of the gastric remnant after Roux-en-Y gastric bypass (RYGB) have not been completely defined, due to its inaccessibility for bioptic mapping. The aim of the study is to evaluate such modifications using Gastropanel®, a non-invasive blood test cross-checking four gastric biomarkers, able to provide a snapshot of mucosa conditions.

Subjects and Methods

Twenty-four women undergoing RYGB were prospectively enrolled. Gastropanel® parameters (pepsinogens, Gastrin-17 and immunoglobulins against Helicobacter pylori), biometrical/clinical data were collected preoperatively and at 6-months follow-up.

Results

All parameters showed significant reduction (p < 0.05). Pepsinogen I reduction correlated with BMI percent decrease.

Conclusions

The exclusion of food transit is responsible for significant drop in gastric output, hardly representing a risk factor in the remnant carcinogenesis, being unexposed to alimentary carcinogenic agents.
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Metadata
Title
The Sleeping Remnant. Effect of Roux-En-Y Gastric Bypass on Plasma Levels of Gastric Biomarkers in Morbidly Obese Women: A Prospective Longitudinal Study
Authors
Federico Marchesi
Francesco Tartamella
Giuseppina De Sario
Clarissa Forlini
Alberta Caleffi
Matteo Riccò
Francesco Di Mario
Publication date
01-07-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 7/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-017-2724-4

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