Published in:
01-09-2008 | Letter to the Editor
The single nucleotide polymorphisms of matrix metalloproteinase-1 in patients with systemic sclerosis
Authors:
Chung-II Joung, Young-In Na, Eun-Soon Shin, Yoon-Kyoung Sung, Dae-Hyun Yoo, Jae-Bum Jun
Published in:
Rheumatology International
|
Issue 11/2008
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Excerpt
Systemic sclerosis (SSc) is a connective tissue disease characterized by endothelial cell damage and activation, excessive accumulation of extracellular matrix (ECM), and fibrosis of the skin and internal organs. The regulation of production and breakdown of ECM is a central event in some physiologic (such as wound healing) and pathological conditions (SSc) [
1]. …