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Published in: Multidisciplinary Respiratory Medicine 1/2014

Open Access 01-12-2014 | Original research article

The safety of beta-blocker use in chronic obstructive pulmonary disease patients with respiratory failure in the intensive care unit

Authors: Feyza Kargin, Huriye Berk Takir, Cuneyt Salturk, Nezihe Ciftaslan Goksenoglu, Can Yucel Karabay, Ozlem Yazicioglu Mocin, Nalan Adiguzel, Gokay Gungor, Merih Kalamanoglu Balci, Murat Yalcinsoy, Ramazan Kargin, Zuhal Karakurt

Published in: Multidisciplinary Respiratory Medicine | Issue 1/2014

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Abstract

Background

The safety of beta-blockers as a heart rate-limiting drug (HRLD) in patients with acute respiratory failure (ARF) due to chronic obstructive lung disease (COPD) has not been properly assessed in the intensive care unit (ICU) setting. This study aims to compare the use of beta-blocker drugs relative to non-beta-blocker ones in COPD patients with ARF due to heart rate-limiting with respect to length of ICU stay and mortality.

Methods

We performed a retrospective (January 2011-December 2012) case-control study in a level III ICU in a teaching hospital. It was carried out in a closed ICU by the same intensivists. All COPD patients with ARF who were treated with beta-blockers (case group) and non-beta-blocker HRLDs (control group) were included. Their demographics, reason for HRLD, cause of ARF, comorbidities, ICU data including acute physiology and chronic health evaluation (APACHE II) score, type of ventilation, heart rate, and lengths of ICU and hospital stays were collected. The mortality rates in the ICU, the hospital, and over 30 days were also recorded.

Results

We enrolled 188 patients (46 female, n = 74 and n = 114 for the case and control groups, respectively). Reasons for HRLD (case and control group, respectively) were atrial fibrillation (AF, 23% and 50%), and supraventricular tachycardia (SVT, 41.9% and 54.4%). Patients’ characteristics, APACHE II score, heart rate, duration and type of ventilation, and median length of ICU-hospital stay were similar between the groups. The mortality outcomes in the ICU, hospital, and 30 days after discharge in the case and control groups were 17.6% versus 15.8% (p > 0.75); 18.9% versus 19.3% (p > 0.95) and 20% versus 11% (p > 0.47), respectively.

Conclusions

Our results suggest that beta-blocker use for heart rate control in COPD patients with ARF is associated with similar ICU stay length and mortality compared with COPD patients treated with other HRLDs.
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Metadata
Title
The safety of beta-blocker use in chronic obstructive pulmonary disease patients with respiratory failure in the intensive care unit
Authors
Feyza Kargin
Huriye Berk Takir
Cuneyt Salturk
Nezihe Ciftaslan Goksenoglu
Can Yucel Karabay
Ozlem Yazicioglu Mocin
Nalan Adiguzel
Gokay Gungor
Merih Kalamanoglu Balci
Murat Yalcinsoy
Ramazan Kargin
Zuhal Karakurt
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Multidisciplinary Respiratory Medicine / Issue 1/2014
Electronic ISSN: 2049-6958
DOI
https://doi.org/10.1186/2049-6958-9-8

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