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Respiratory Research
Published in: Respiratory Research 1/2017

Open Access 01-12-2017 | Review

The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration

Authors: Dale D. Tang, Brennan D. Gerlach

Published in: Respiratory Research | Issue 1/2017

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Abstract

Smooth muscle cell migration has been implicated in the development of respiratory and cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized cellular process involving a protrusive cell front and a retracting trailing rear. There are three cytoskeletal systems in mammalian cells: the actin cytoskeleton, the intermediate filament network, and microtubules; all of which regulate all or part of the migrated process. The dynamic actin cytoskeleton spatially and temporally regulates protrusion, adhesions, contraction, and retraction from the cell front to the rear. c-Abl tyrosine kinase plays a critical role in regulating actin dynamics and migration of airway smooth muscle cells and nonmuscle cells. Recent studies suggest that intermediate filaments undergo reorganization during migration, which coordinates focal adhesion dynamics, cell contraction, and nucleus rigidity. In particular, vimentin intermediate filaments undergo phosphorylation and reorientation in smooth muscle cells, which may regulate cell contraction and focal adhesion assembly/disassembly. Motile cells are characterized by a front-rear polarization of the microtubule framework, which regulates all essential processes leading to cell migration through its role in cell mechanics, intracellular trafficking, and signaling. This review recapitulates our current knowledge how the three cytoskeletal systems spatially and temporally modulate the migratory properties of cells. We also summarize the potential role of migration-associated biomolecules in lung and vascular diseases.
Literature
1.
2.
Tang DD. Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling. Respir Res. 2015;16:134.PubMedPubMedCentralCrossRef
3.
Cleary RA, Wang R, Waqar O, Singer HA, Tang DD. Role of c-Abl tyrosine kinase in smooth muscle cell migration. Am J Physiol Cell Physiol. 2014;306:C753–61.PubMedPubMedCentralCrossRef
4.
5.
Krause M, Gautreau A. Steering cell migration: lamellipodium dynamics and the regulation of directional persistence. Nat Rev Mol Cell Biol. 2014;15:577–90.PubMedCrossRef
6.
Tang DD, Zhang W, Gunst SJ. The adapter protein CrkII regulates neuronal wiskott-aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. J Biol Chem. 2005;280:23380–9.PubMedCrossRef
7.
Pollard TD. Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct. 2017;36:451–77.
8.
Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell. 2003;112:453–65.PubMedCrossRef
9.
Nguyen TT, Park WS, Park BO, Kim CY, Oh Y, Kim JM, Choi H, Kyung T, Kim CH, Lee G, et al. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Proc Natl Acad Sci U S A. 2016;113:10091–6.PubMedPubMedCentralCrossRef
10.
Wang R, Cleary RA, Wang T, Li J, Tang DD. The association of cortactin with profilin-1 is critical for smooth muscle contraction. J Biol Chem. 2014;289:14157–69.PubMedPubMedCentralCrossRef
11.
12.
13.
Wang T, Cleary RA, Wang R, Tang DD. Role of the adapter protein Abi1 in actin-associated signaling and smooth muscle contraction. J Biol Chem. 2013;288:20713–22.PubMedPubMedCentralCrossRef
14.
Wang R, Mercaitis OP, Jia L, Panettieri RA, Tang DD. Raf-1, actin dynamics and Abl in human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2013;48:172–8.PubMedPubMedCentralCrossRef
15.
Jia L, Wang R, Tang DD. Abl regulates smooth muscle cell proliferation by modulating actin dynamics and ERK1/2 activation. Am J Physiol Cell Physiol. 2012;302:C1026–34.PubMedPubMedCentralCrossRef
16.
Vallieres K, Petitclerc E, Laroche G. On the ability of imatinib mesylate to inhibit smooth muscle cell proliferation without delaying endothelialization: an in vitro study. Vascul Pharmacol. 2009;51:50–6.PubMedCrossRef
17.
Ozgur-Akdemir A, Demirturk K, Karabakan M, Volkan-Oztekin C, Abdulkadir NA, Cetinkaya M, Gur S, Hellstrom WJ. Imatinib mesylate (Gleevec) as protein-tyrosine kinase inhibitor elicits smooth muscle relaxation in isolated human prostatic tissue. Urology. 2011;78:968 e961–966.CrossRef
18.
Lapetina S, Mader CC, Machida K, Mayer BJ, Koleske AJ. Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. J Cell Biol. 2009;185:503–19.PubMedPubMedCentralCrossRef
19.
Kheir WA, Gevrey JC, Yamaguchi H, Isaac B, Cox D. A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages. J Cell Sci. 2005;118:5369–79.PubMedCrossRef
20.
Anfinogenova Y, Wang R, Li QF, Spinelli AM, Tang DD. Abl silencing inhibits CAS-Mediated process and constriction in resistance arteries. Circ Res. 2007;101:420–8.PubMedPubMedCentralCrossRef
21.
Ogden K, Thompson JM, Hickner Z, Huang T, Tang DD, Watts SW. A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contraction. Am J Physiol Heart Circ Physiol. 2006;291:H2857–63.PubMedCrossRef
22.
Ring C, Ginsberg MH, Haling J, Pendergast AM. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Proc Natl Acad Sci U S A. 2011;108:149–54.PubMedCrossRef
23.
Matthews JD, Sumagin R, Hinrichs B, Nusrat A, Parkos CA, Neish AS. Redox control of Cas phosphorylation requires Abl kinase in regulation of intestinal epithelial cell spreading and migration. Am J Physiol Gastrointest Liver Physiol. 2016;311:G458–65.PubMedCrossRef
24.
Defawe OD, Kim S, Chen L, Huang D, Kenagy RD, Renne T, Walter U, Daum G, Clowes AW. VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen. J Cell Physiol. 2010;222:230–7.PubMedPubMedCentralCrossRef
25.
Kim HR, Graceffa P, Ferron F, Gallant C, Boczkowska M, Dominguez R, Morgan KG. Actin polymerization in differentiated vascular smooth muscle cells requires vasodilator-stimulated phosphoprotein. Am J Physiol Cell Physiol. 2010;298:C559–71.PubMedCrossRef
26.
Wang T, Wang R, Cleary RA, Gannon OJ, Tang DD. Recruitment of beta-Catenin to N-Cadherin is necessary for smooth muscle contraction. J Biol Chem. 2015;290:8913–24.PubMedPubMedCentralCrossRef
27.
Shamir ER, Ewald AJ. Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration. Curr Top Dev Biol. 2015;112:353–82.PubMedPubMedCentralCrossRef
28.
Ydenberg CA, Padrick SB, Sweeney MO, Gandhi M, Sokolova O, Goode BL. GMF severs Actin-Arp2/3 complex branch junctions by a cofilin-like mechanism. Curr Biol. 2013;23:1037–45.PubMedPubMedCentralCrossRef
29.
Poukkula M, Hakala M, Pentinmikko N, Sweeney MO, Jansen S, Mattila J, Hietakangas V, Goode BL, Lappalainen P. GMF promotes leading-edge dynamics and collective cell migration in vivo. Curr Biol. 2014;24:2533–40.PubMedPubMedCentralCrossRef
30.
31.
Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP. Glia maturation factor-gamma mediates neutrophil chemotaxis. J Leukoc Biol. 2011;90:529–38.PubMedPubMedCentralCrossRef
32.
Brennan Gerlach RAC, Olivia J. Gannon, Dale D. Tang. Glia Maturation Factor-gamma (GMFG) and Human Airway Smooth Muscle Cell Migration. Am J Respir Crit Care Med. 2015;191:A5586.
33.
Wang T, Cleary RA, Wang R, Tang DD. Glia maturation factor-gamma phosphorylation at Tyr-104 regulates actin dynamics and contraction in human airway smooth muscle. Am J Respir Cell Mol Biol. 2014;51:652–9.PubMedPubMedCentralCrossRef
34.
35.
Tang DD, Anfinogenova Y. Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J Cardiovasc Pharmacol Ther. 2008;13:130–40.PubMedPubMedCentralCrossRef
36.
Tang DD, Wu MF, Opazo Saez AM, Gunst SJ. The focal adhesion protein paxillin regulates contraction in canine tracheal smooth muscle. J Physiol. 2002;542:501–13.PubMedPubMedCentralCrossRef
37.
Tang DD, Gunst SJ. Depletion of focal adhesion kinase by antisense depresses contractile activation of smooth muscle. Am J Physiol Cell Physiol. 2001;280:C874–83.PubMed
38.
Serrels B, Serrels A, Brunton VG, Holt M, McLean GW, Gray CH, Jones GE, Frame MC. Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol. 2007;9:1046–56.PubMedCrossRef
39.
Schoenwaelder SM, Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Curr Opin Cell Biol. 1999;11:274–86.PubMedCrossRef
40.
Tang D, Mehta D, Gunst SJ. Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle. Am J Physiol. 1999;276:C250–8.PubMed
41.
Lim BC, Matsumoto S, Yamamoto H, Mizuno H, Kikuta J, Ishii M, Kikuchi A. Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5beta complex in migrating cells. J Cell Sci. 2016;129:3115–29.PubMedCrossRef
42.
Colo GP, Hernandez-Varas P, Lock J, Bartolome RA, Arellano-Sanchez N, Stromblad S, Teixido J. Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway. J Cell Sci. 2012;125:5338–52.PubMedCrossRef
43.
Wilson E, Leszczynska K, Poulter NS, Edelmann F, Salisbury VA, Noy PJ, Bacon A, Rappoport JZ, Heath JK, Bicknell R, Heath VL. RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly. J Cell Sci. 2014;127:3039–51.PubMedPubMedCentralCrossRef
44.
Murali A, Rajalingam K. Small Rho GTPases in the control of cell shape and mobility. Cell Mol Life Sci. 2014;71:1703–21.PubMedCrossRef
45.
Ai S, Kuzuya M, Koike T, Asai T, Kanda S, Maeda K, Shibata T, Iguchi A. Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways. Atherosclerosis. 2001;155:321–7.PubMedCrossRef
46.
Liu BP, Burridge K. Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Mol Cell Biol. 2000;20:7160–9.PubMedPubMedCentralCrossRef
47.
Garrett TA, Van Buul JD, Burridge K. VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2. Exp Cell Res. 2007;313:3285–97.PubMedPubMedCentralCrossRef
48.
Freed DH, Chilton L, Li Y, Dangerfield AL, Raizman JE, Rattan SG, Visen N, Hryshko LV, Dixon IM. Role of myosin light chain kinase in cardiotrophin-1-induced cardiac myofibroblast cell migration. Am J Physiol Heart Circ Physiol. 2011;301:H514–22.PubMedCrossRef
49.
50.
51.
Jia L, Tang DD. Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle. Am J Physiol Cell Physiol. 2010;299:C630–7.PubMedPubMedCentralCrossRef
52.
Wang R, Li QF, Anfinogenova Y, Tang DD. Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;292:L240–8.PubMedCrossRef
53.
54.
Ivaska J, Pallari HM, Nevo J, Eriksson JE. Novel functions of vimentin in cell adhesion, migration, and signaling. Exp Cell Res. 2007;313:2050–62.PubMedCrossRef
55.
Eckes B, Dogic D, Colucci-Guyon E, Wang N, Maniotis A, Ingber D, Merckling A, Langa F, Aumailley M, Delouvee A, et al. Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts. J Cell Sci. 1998;111(Pt 13):1897–907.PubMed
56.
Leduc C, Etienne-Manneville S. Intermediate filaments in cell migration and invasion: the unusual suspects. Curr Opin Cell Biol. 2015;32:102–12.PubMedCrossRef
57.
Sjuve R, Arner A, Li Z, Mies B, Paulin D, Schmittner M, Small JV. Mechanical alterations in smooth muscle from mice lacking desmin. J Muscle Res Cell Motil. 1998;19:415–29.PubMedCrossRef
58.
Lobrinus JA, Janzer RC, Kuntzer T, Matthieu JM, Pfend G, Goy JJ, Bogousslavsky J. Familial cardiomyopathy and distal myopathy with abnormal desmin accumulation and migration. Neuromuscul Disord. 1998;8:77–86.PubMedCrossRef
59.
Mendez MG, Kojima S, Goldman RD. Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J. 2010;24:1838–51.PubMedPubMedCentralCrossRef
60.
Kim J, Yang C, Kim EJ, Jang J, Kim SJ, Kang SM, Kim MG, Jung H, Park D, Kim C. Vimentin filaments regulate integrin-ligand interactions by binding to the cytoplasmic tail of integrin beta3. J Cell Sci. 2016;129:2030–42.PubMedCrossRef
61.
Havel LS, Kline ER, Salgueiro AM, Marcus AI. Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity. Oncogene. 2015;34:1979–90.PubMedCrossRef
62.
Burgstaller G, Gregor M, Winter L, Wiche G. Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts. Mol Biol Cell. 2010;21:3362–75.PubMedPubMedCentralCrossRef
63.
Gregor M, Osmanagic-Myers S, Burgstaller G, Wolfram M, Fischer I, Walko G, Resch GP, Jorgl A, Herrmann H, Wiche G. Mechanosensing through focal adhesion-anchored intermediate filaments. FASEB J. 2014;28:715–29.PubMedCrossRef
64.
65.
Li QF, Spinelli AM, Wang R, Anfinogenova Y, Singer HA, Tang DD. Critical role of vimentin phosphorylation at Ser-56 by p21-activated kinase in vimentin cytoskeleton signaling. J Biol Chem. 2006;281:34716–24.PubMedPubMedCentralCrossRef
66.
Ivaska J, Vuoriluoto K, Huovinen T, Izawa I, Inagaki M, Parker PJ. PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J. 2005;24:3834–45.PubMedPubMedCentralCrossRef
67.
Li J, Wang R, Gannon OJ, Rezey AC, Jiang S, Gerlach BD, Liao G, Tang DD. Polo-like kinase 1 regulates vimentin phosphorylation at Ser-56 and contraction in smooth muscle. J Biol Chem. 2016;291:23693–703.PubMedCrossRef
68.
69.
Liu T, Ghamloush MM, Aldawood A, Warburton R, Toksoz D, Hill NS, Tang DD, Kayyali US. Modulating endothelial barrier function by targeting vimentin phosphorylation. J Cell Physiol. 2014;229:1484–93.PubMedCrossRef
70.
Thaiparambil JT, Bender L, Ganesh T, Kline E, Patel P, Liu Y, Tighiouart M, Vertino PM, Harvey RD, Garcia A, Marcus AI. Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. Int J Cancer. 2011;129:2744–55.PubMedCrossRef
71.
Kong L, Schafer G, Bu H, Zhang Y, Zhang Y, Klocker H. Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. Carcinogenesis. 2012;33:751–9.PubMedCrossRef
72.
Wu Z, Wu L, Weng D, Xu D, Geng J, Zhao F. Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma. J Exp Clin Cancer Res. 2009;28:8.PubMedPubMedCentralCrossRef
73.
Carboni N, Mateddu A, Marrosu G, Cocco E, Marrosu MG. Genetic and clinical characteristics of skeletal and cardiac muscle in patients with lamin A/C gene mutations. Muscle Nerve. 2013;48:161–70.PubMedCrossRef
74.
Helfand BT, Mendez MG, Murthy SN, Shumaker DK, Grin B, Mahammad S, Aebi U, Wedig T, Wu YI, Hahn KM, et al. Vimentin organization modulates the formation of lamellipodia. Mol Biol Cell. 2011;22:1274–89.PubMedPubMedCentralCrossRef
75.
Deng M, Mohanan S, Polyak E, Chacko S. Caldesmon is necessary for maintaining the actin and intermediate filaments in cultured bladder smooth muscle cells. Cell Motil Cytoskeleton. 2007;64:951–65.PubMedCrossRef
76.
Leung WK, Ching AK, Wong N. Phosphorylation of Caldesmon by PFTAIRE1 kinase promotes actin binding and formation of stress fibers. Mol Cell Biochem. 2011;350:201–6.PubMedCrossRef
77.
Lanier MH, Kim T, Cooper JA. CARMIL2 is a novel molecular connection between vimentin and actin essential for cell migration and invadopodia formation. Mol Biol Cell. 2015;26:4577–88.PubMedPubMedCentralCrossRef
78.
Gan Z, Ding L, Burckhardt CJ, Lowery J, Zaritsky A, Sitterley K, Mota A, Costigliola N, Starker CG, Voytas DF, et al. Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration. Cell Syst. 2016;3:252–63. e258.PubMedCrossRef
79.
Shabbir SH, Cleland MM, Goldman RD, Mrksich M. Geometric control of vimentin intermediate filaments. Biomaterials. 2014;35:1359–66.PubMedCrossRef
80.
81.
Zhu X, Efimova N, Arnette C, Hanks SK, Kaverina I. Podosome dynamics and location in vascular smooth muscle cells require CLASP-dependent microtubule bending. Cytoskeleton (Hoboken). 2016;73:300–15.CrossRef
82.
Silverman-Gavrila RV, Silverman-Gavrila LB, Bilal KH, Bendeck MP. Spectrin alpha is important for rear polarization of the microtubule organizing center during migration and spindle pole assembly during division of neointimal smooth muscle cells. Cytoskeleton (Hoboken). 2015;72:157–70.CrossRef
83.
Silverman-Gavrila R, Silverman-Gavrila L, Hou G, Zhang M, Charlton M, Bendeck MP. Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKCalpha, ARPC5, and RHAMM. Am J Pathol. 2011;178:895–910.PubMedPubMedCentralCrossRef
84.
Kawabe J, Okumura S, Nathanson MA, Hasebe N, Ishikawa Y. Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Biochem Biophys Res Commun. 2006;342:164–9.PubMedCrossRef
85.
Brangwynne CP, MacKintosh FC, Weitz DA. Force fluctuations and polymerization dynamics of intracellular microtubules. Proc Natl Acad Sci U S A. 2007;104:16128–33.PubMedPubMedCentralCrossRef
86.
Yadav S, Puri S, Linstedt AD. A primary role for Golgi positioning in directed secretion, cell polarity, and wound healing. Mol Biol Cell. 2009;20:1728–36.PubMedPubMedCentralCrossRef
87.
Palamidessi A, Frittoli E, Garre M, Faretta M, Mione M, Testa I, Diaspro A, Lanzetti L, Scita G, Di Fiore PP. Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell. 2008;134:135–47.PubMedCrossRef
88.
Osmani N, Peglion F, Chavrier P, Etienne-Manneville S. Cdc42 localization and cell polarity depend on membrane traffic. J Cell Biol. 2010;191:1261–9.PubMedPubMedCentralCrossRef
89.
Rooney C, White G, Nazgiewicz A, Woodcock SA, Anderson KI, Ballestrem C, Malliri A. The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. EMBO Rep. 2010;11:292–8.PubMedPubMedCentralCrossRef
90.
Gu Z, Noss EH, Hsu VW, Brenner MB. Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration. J Cell Biol. 2011;193:61–70.PubMedPubMedCentralCrossRef
91.
Villari G, Jayo A, Zanet J, Fitch B, Serrels B, Frame M, Stramer BM, Goult BT, Parsons M. A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration. J Cell Sci. 2015;128:4601–14.PubMedPubMedCentralCrossRef
92.
Waterman-Storer CM, Salmon E. Positive feedback interactions between microtubule and actin dynamics during cell motility. Curr Opin Cell Biol. 1999;11:61–7.PubMedCrossRef
93.
94.
95.
Shpetner HS, Vallee RB. Dynamin is a GTPase stimulated to high levels of activity by microtubules. Nature. 1992;355:733–5.PubMedCrossRef
96.
97.
Daniel JM, Bielenberg W, Stieger P, Weinert S, Tillmanns H, Sedding DG. Time-course analysis on the differentiation of bone marrow-derived progenitor cells into smooth muscle cells during neointima formation. Arterioscler Thromb Vasc Biol. 2010;30:1890–6.PubMedCrossRef
98.
Rhee CK, Kim JW, Park CK, Kim JS, Kang JY, Kim SJ, Kim SC, Kwon SS, Kim YK, Park SH, Lee SY. Effect of imatinib on airway smooth muscle thickening in a murine model of chronic asthma. Int Arch Allergy Immunol. 2011;155:243–51.PubMedCrossRef
99.
Liang L, Li F, Bao A, Zhang M, Chung KF, Zhou X. Activation of p38 mitogen-activated protein kinase in ovalbumin and ozone-induced mouse model of asthma. Respirology. 2013;18 Suppl 3:20–9.PubMedCrossRef
100.
101.
102.
Dekkers BG, Bos IS, Gosens R, Halayko AJ, Zaagsma J, Meurs H. The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am J Respir Crit Care Med. 2010;181:556–65.PubMedCrossRef
103.
Ma SF, Flores C, Wade MS, Dudek SM, Nicolae DL, Ober C, Garcia JG. A common cortactin gene variation confers differential susceptibility to severe asthma. Genet Epidemiol. 2008;32:757–66.PubMedPubMedCentralCrossRef
104.
Kumawat K, Koopmans T, Gosens R. beta-catenin as a regulator and therapeutic target for asthmatic airway remodeling. Expert Opin Ther Targets. 2014;18:1023–34.PubMedCrossRef
105.
Lim DH, Cho JY, Song DJ, Lee SY, Miller M, Broide DH. PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2009;296:L210–9.PubMedCrossRef
106.
Ghofrani HA, Seeger W, Grimminger F. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med. 2005;353:1412–3.PubMedCrossRef
107.
ten Freyhaus H, Dumitrescu D, Berghausen E, Vantler M, Caglayan E, Rosenkranz S. Imatinib mesylate for the treatment of pulmonary arterial hypertension. Expert Opin Investig Drugs. 2012;21:119–34.PubMedCrossRef
108.
Wang Y, Zhang J, Gao H, Zhao S, Ji X, Liu X, You B, Li X, Qiu J. Profilin-1 promotes the development of hypertension-induced artery remodeling. J Histochem Cytochem. 2014;62:298–310.PubMedPubMedCentralCrossRef
109.
Schiffers PM, Henrion D, Boulanger CM, Colucci-Guyon E, Langa-Vuves F, van Essen H, Fazzi GE, Levy BI, De Mey JG. Altered flow-induced arterial remodeling in vimentin-deficient mice. Arterioscler Thromb Vasc Biol. 2000;20:611–6.PubMedCrossRef
110.
Karki R, Kim SB, Kim DW. Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation. Exp Cell Res. 2013;319:3238–50.PubMedCrossRef
111.
Lassila M, Allen TJ, Cao Z, Thallas V, Jandeleit-Dahm KA, Candido R, Cooper ME. Imatinib attenuates diabetes-associated atherosclerosis. Arterioscler Thromb Vasc Biol. 2004;24:935–42.PubMedCrossRef
112.
Toure F, Fritz G, Li Q, Rai V, Daffu G, Zou YS, Rosario R, Ramasamy R, Alberts AS, Yan SF, Schmidt AM. Formin mDia1 mediates vascular remodeling via integration of oxidative and signal transduction pathways. Circ Res. 2012;110:1279–93.PubMedPubMedCentralCrossRef
Metadata
Title
The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration
Authors
Dale D. Tang
Brennan D. Gerlach
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2017
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-017-0544-7

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