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Current Nutrition Reports
Published in: Current Nutrition Reports 2/2016

01-06-2016 | Nutrition and Aging (MC Serra, Section Editor)

The Role of Vitamin K in Chronic Aging Diseases: Inflammation, Cardiovascular Disease, and Osteoarthritis

Authors: Stephanie G. Harshman, M. Kyla Shea

Published in: Current Nutrition Reports | Issue 2/2016

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Abstract

Vitamin K is an enzyme cofactor required for the carboxylation of vitamin K-dependent proteins, several of which have been implicated in diseases of aging. Inflammation is recognized as a crucial component of many chronic aging diseases, and evidence suggests vitamin K has an anti-inflammatory action that is independent of its role as an enzyme cofactor. Vitamin K-dependent proteins and inflammation have been implicated in cardiovascular disease and osteoarthritis, which are leading causes of disability and mortality in older adults. The purpose of this review is to summarize observational studies and randomized trials focused on vitamin K status and inflammation, cardiovascular disease, and osteoarthritis. Although mechanistic evidence suggests a protective role for vitamin K in these age-related conditions, the benefit of vitamin K supplementation is controversial because observational data are equivocal and the number of randomized trials is few.
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Metadata
Title
The Role of Vitamin K in Chronic Aging Diseases: Inflammation, Cardiovascular Disease, and Osteoarthritis
Authors
Stephanie G. Harshman
M. Kyla Shea
Publication date
01-06-2016
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 2/2016
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-016-0162-x

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