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Molecular Neurodegeneration
Published in: Molecular Neurodegeneration 1/2014

Open Access 01-12-2014 | Review

The role of tau protein in HIV-associated neurocognitive disorders

Authors: Lecia AM Brown, James Scarola, Adam J Smith, Paul R Sanberg, Jun Tan, Brian Giunta

Published in: Molecular Neurodegeneration | Issue 1/2014

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Abstract

Given the increased life expectancy of human immunodeficiency virus (HIV) infected individuals treated with combination antiretroviral therapy (cART) and the ongoing inflammation observed in the brains of these patients, it is likely that premature neurodegeneration as measured by phospho-tau (p-tau) or increased total tau (t-tau) protein may become an increasing problem. This review examines the seven human studies that have occurred over the past 14 years measuring p-tau and/or t-tau in cerebrospinal fluid (CSF) or via post-mortem brain immunohistochemistry. Although not all studies are in agreement as to the changes in p-and t-tau in HIV infected patients, HIV persists in the brain despite cART. Thus is it is suggested that those maintained on long-term cART may develop tau pathology beyond the extent seen in the studies reviewed herein and overtime may then reach the threshold for clinical manifestation.
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Metadata
Title
The role of tau protein in HIV-associated neurocognitive disorders
Authors
Lecia AM Brown
James Scarola
Adam J Smith
Paul R Sanberg
Jun Tan
Brian Giunta
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue 1/2014
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/1750-1326-9-40

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