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Published in:

01-03-2024 | Review

The role of pyroptosis in viral infection

Authors: Zhen Zhao, Yan Zhang, Bing Luo

Published in: Archives of Virology | Issue 3/2024

Abstract

Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death, which is an important natural immune response. Pyroptosis plays a major role in combating pathogenic infections. The mechanism of pyroptosis is distinct from other forms of cell death and is characterized by its dependence on inflammatory caspases (mainly caspases 1, 4, 5, and 11). Activation of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammatory vesicles is involved in caspase-1 activation and cleavage, which in turn triggers cleavage and multimerization of multiple gasdermin family members, including gasdermin-D (GSDMD). This further leads to cell perforation and cellular distension, causing cell membrane rupture, resulting in a massive efflux of cell contents, which triggers inflammatory reactions. In recent years, detailed study of viral diseases, has demonstrated that pyroptosis is closely associated with the development of viral diseases. This article focuses on the mechanism of pyroptosis and the connection between pyroptosis and viral infection.

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Title: The role of pyroptosis in viral infection
Authors: Zhen Zhao
Yan Zhang
Bing Luo
Publication date: 01-03-2024
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 3/2024
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-024-05978-9

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