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Journal of Gastroenterology
Published in: Journal of Gastroenterology 2/2014

01-02-2014 | Review

The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects

Authors: Motoyuki Otsuka, Takahiro Kishikawa, Takeshi Yoshikawa, Motoko Ohno, Akemi Takata, Chikako Shibata, Kazuhiko Koike

Published in: Journal of Gastroenterology | Issue 2/2014

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Abstract

MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate gene expression post-transcriptionally through complementary base pairing with thousands of messenger RNAs. Although the precise biological functions of individual miRNAs are still unknown, miRNAs are speculated to play important roles in diverse biological processes through fine regulation of their target gene expression. A growing body of data indicates the deregulation of miRNAs during hepatocarcinogenesis. In this review, we summarize recent findings regarding deregulated miRNA expression and their possible target genes in hepatocarcinogenesis, with emphasis on inflammation-related hepatocarcinogenesis. Because miRNA-based strategies are being applied to clinical therapeutics, precise knowledge of miRNA functions is crucial both scientifically and clinically. We discuss the current open questions from these points of view, which must be clarified in the near future.
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Metadata
Title
The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects
Authors
Motoyuki Otsuka
Takahiro Kishikawa
Takeshi Yoshikawa
Motoko Ohno
Akemi Takata
Chikako Shibata
Kazuhiko Koike
Publication date
01-02-2014
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 2/2014
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-013-0909-8

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