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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2010

01-04-2010 | Review

The role of dendritic cells in the pathogenesis of systemic lupus erythematosus

Authors: Justin H Fransen, Johan van der Vlag, Jurjen Ruben, Gosse J Adema, Jo H Berden, Luuk B Hilbrands

Published in: Arthritis Research & Therapy | Issue 2/2010

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Abstract

The etiology of the autoimmune disease systemic lupus erythematosus is not known, but aberrant apoptosis and/or insufficient clearance of apoptotic material have been assigned a pivotal role. During apoptosis, nucleosomes and several endogenous danger-associated molecular patterns are incorporated in blebs. Recent data indicate that apoptotic blebs induce maturation of myeloid dendritic cells, resulting in IL-17 production by T cells. In this review we summarize current knowledge on the role of dendritic cells in the pathogenesis of systemic lupus erythematosus with special emphasis on the uptake of apoptotic blebs by dendritic cells, and the subsequent induction of Th17 cells.
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Metadata
Title
The role of dendritic cells in the pathogenesis of systemic lupus erythematosus
Authors
Justin H Fransen
Johan van der Vlag
Jurjen Ruben
Gosse J Adema
Jo H Berden
Luuk B Hilbrands
Publication date
01-04-2010
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2010
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2966

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