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Translational Neurodegeneration
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Open Access 01-12-2017 | Review

The role of cognitive activity in cognition protection: from Bedside to Bench

Authors: Bin-Yin Li, Ying Wang, Hui-dong Tang, Sheng-Di Chen

Published in: Translational Neurodegeneration | Issue 1/2017

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Abstract

Background

Cognitive decline poses a great concern to elderly people and their families. In addition to pharmacological therapies, several varieties of nonpharmacological intervention have been developed. Most training trials proved that a well-organized task is clinically effective in cognition improvement.

Main body

We will first review clinical trials of cognitive training for healthy elders, MCI and AD patients, respectively. Besides, potential neuroprotective and compensatory mechanisms in animal models of AD are discussed. Despite controversy, cognitive training has promising effect on cognitive ability. In animal model of AD, environmental enrichment showed beneficial effect for cognitive ability, as well as neuronal plasticity. Neurotrophin, neurotransmitter and neuromodulator signaling pathway were also involved in the process. Well-designed cognitive activity could benefit cognitive function, and thus life quality of patients and their families.

Conclusion

The positive effects of cognitive activity is closely related with neural plasticity, neurotrophin, neurotransmitter and neuromodulator signaling pathway changes.
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Metadata
Title
The role of cognitive activity in cognition protection: from Bedside to Bench
Authors
Bin-Yin Li
Ying Wang
Hui-dong Tang
Sheng-Di Chen
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Translational Neurodegeneration / Issue 1/2017
Electronic ISSN: 2047-9158
DOI
https://doi.org/10.1186/s40035-017-0078-4

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