The role of body size and physical activity on the risk of breast cancer in BRCA mutation carriers

go back to reference Lubinski J, Huzarski T, Byrski T, Lynch HT, Cybulski C, Ghadirian P, Stawicka M, Foulkes WD, Kilar E, Kim-Sing C, Neuhausen SL, Armel S, Gilchrist D, Sweet K, Gronwald J, Eisen A, Gorski B, Sun P, Narod SA (2012) The risk of breast cancer in women with a BRCA1 mutation from North America and Poland. Int J Cancer 131(1):229–234. doi:10.1002/ijc.26369 CrossRefPubMedCentralPubMed Lubinski J, Huzarski T, Byrski T, Lynch HT, Cybulski C, Ghadirian P, Stawicka M, Foulkes WD, Kilar E, Kim-Sing C, Neuhausen SL, Armel S, Gilchrist D, Sweet K, Gronwald J, Eisen A, Gorski B, Sun P, Narod SA (2012) The risk of breast cancer in women with a BRCA1 mutation from North America and Poland. Int J Cancer 131(1):229–234. doi:10.​1002/​ijc.​26369 CrossRefPubMedCentralPubMed

go back to reference Mavaddat N, Peock S, Frost D, Ellis S, Platte R, Fineberg E, Evans DG, Izatt L, Eeles RA, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Brewer C, Tischkowitz M, Douglas F, Hodgson S, Walker L, Porteous ME, Morrison PJ, Side LE, Kennedy MJ, Houghton C, Donaldson A, Rogers MT, Dorkins H, Miedzybrodzka Z, Gregory H, Eason J, Barwell J, McCann E, Murray A, Antoniou AC, Easton DF, Embrace (2013) Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE. J Natl Cancer Inst 105(11):812–822. doi:10.1093/jnci/djt095 CrossRefPubMed Mavaddat N, Peock S, Frost D, Ellis S, Platte R, Fineberg E, Evans DG, Izatt L, Eeles RA, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Brewer C, Tischkowitz M, Douglas F, Hodgson S, Walker L, Porteous ME, Morrison PJ, Side LE, Kennedy MJ, Houghton C, Donaldson A, Rogers MT, Dorkins H, Miedzybrodzka Z, Gregory H, Eason J, Barwell J, McCann E, Murray A, Antoniou AC, Easton DF, Embrace (2013) Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE. J Natl Cancer Inst 105(11):812–822. doi:10.​1093/​jnci/​djt095 CrossRefPubMed

go back to reference Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjakoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG, Easton DF (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72(5):1117–1130. doi:10.1086/375033 CrossRefPubMedCentralPubMed Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjakoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG, Easton DF (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72(5):1117–1130. doi:10.​1086/​375033 CrossRefPubMedCentralPubMed

go back to reference Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Kwan E, Jack E, Vesprini DJ, Kuperstein G, Abrahamson JL, Fan I, Wong B, Narod SA (2001) Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet 68(3):700–710. doi:10.1086/318787 CrossRefPubMedCentralPubMed Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Kwan E, Jack E, Vesprini DJ, Kuperstein G, Abrahamson JL, Fan I, Wong B, Narod SA (2001) Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet 68(3):700–710. doi:10.​1086/​318787 CrossRefPubMedCentralPubMed

go back to reference Narod SA (2010) BRCA mutations in the management of breast cancer: the state of the art. Nat Rev Clin Oncol 7(12):702–707. doi:10.1038/nrclinonc.2010.166 CrossRefPubMed Narod SA (2010) BRCA mutations in the management of breast cancer: the state of the art. Nat Rev Clin Oncol 7(12):702–707. doi:10.​1038/​nrclinonc.​2010.​166 CrossRefPubMed

go back to reference Metcalfe K, Gershman S, Lynch HT, Ghadirian P, Tung N, Kim-Sing C, Olopade OI, Domchek S, McLennan J, Eisen A, Foulkes WD, Rosen B, Sun P, Narod SA (2011) Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. Br J Cancer 104(9):1384–1392. doi:10.1038/bjc.2011.120 CrossRefPubMedCentralPubMed Metcalfe K, Gershman S, Lynch HT, Ghadirian P, Tung N, Kim-Sing C, Olopade OI, Domchek S, McLennan J, Eisen A, Foulkes WD, Rosen B, Sun P, Narod SA (2011) Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. Br J Cancer 104(9):1384–1392. doi:10.​1038/​bjc.​2011.​120 CrossRefPubMedCentralPubMed

go back to reference Metcalfe K, Lynch HT, Ghadirian P, Tung N, Kim-Sing C, Olopade OI, Domchek S, Eisen A, Foulkes WD, Rosen B, Vesprini D, Sun P, Narod SA (2011) Risk of ipsilateral breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 127(1):287–296. doi:10.1007/s10549-010-1336-7 CrossRefPubMed Metcalfe K, Lynch HT, Ghadirian P, Tung N, Kim-Sing C, Olopade OI, Domchek S, Eisen A, Foulkes WD, Rosen B, Vesprini D, Sun P, Narod SA (2011) Risk of ipsilateral breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 127(1):287–296. doi:10.​1007/​s10549-010-1336-7 CrossRefPubMed

go back to reference Da Silva L, Lakhani SR (2010) Pathology of hereditary breast cancer. Mod Pathol 23(Suppl 2):S46–S51. doi:10.1038/modpathol.2010.37 CrossRefPubMed Da Silva L, Lakhani SR (2010) Pathology of hereditary breast cancer. Mod Pathol 23(Suppl 2):S46–S51. doi:10.​1038/​modpathol.​2010.​37 CrossRefPubMed

go back to reference Scully R, Livingston DM (2000) In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408(6811):429–432. doi:10.1038/35044000 CrossRefPubMedCentralPubMed Scully R, Livingston DM (2000) In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408(6811):429–432. doi:10.​1038/​35044000 CrossRefPubMedCentralPubMed

go back to reference Welcsh PL, Schubert EL, King MC (1998) Inherited breast cancer: an emerging picture. Clin Genet 54(6):447–458CrossRefPubMed Welcsh PL, Schubert EL, King MC (1998) Inherited breast cancer: an emerging picture. Clin Genet 54(6):447–458CrossRefPubMed

go back to reference Elledge SJ, Amon A (2002) The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell 1(2):129–132CrossRefPubMed Elledge SJ, Amon A (2002) The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell 1(2):129–132CrossRefPubMed

go back to reference Monteiro AN (2003) BRCA1: the enigma of tissue-specific tumor development. Trends Genet 19(6):312–315. doi:10.1016/S0168-9525(03)00110-0 CrossRefPubMed Monteiro AN (2003) BRCA1: the enigma of tissue-specific tumor development. Trends Genet 19(6):312–315. doi:10.​1016/​S0168-9525(03)00110-0 CrossRefPubMed

go back to reference Rosen EM, Fan S, Isaacs C (2005) BRCA1 in hormonal carcinogenesis: basic and clinical research. Endocr Relat Cancer 12(3):533–548. doi:10.1677/erc.1.00972 CrossRefPubMed Rosen EM, Fan S, Isaacs C (2005) BRCA1 in hormonal carcinogenesis: basic and clinical research. Endocr Relat Cancer 12(3):533–548. doi:10.​1677/​erc.​1.​00972 CrossRefPubMed

go back to reference Noruzinia M, Coupier I, Pujol P (2005) Is BRCA1/BRCA2-related breast carcinogenesis estrogen dependent? Cancer 104(8):1567–1574. doi:10.1002/cncr.21367 CrossRefPubMed Noruzinia M, Coupier I, Pujol P (2005) Is BRCA1/BRCA2-related breast carcinogenesis estrogen dependent? Cancer 104(8):1567–1574. doi:10.​1002/​cncr.​21367 CrossRefPubMed

go back to reference Metcalfe KA, Birenbaum-Carmeli D, Lubinski J, Gronwald J, Lynch H, Moller P, Ghadirian P, Foulkes WD, Klijn J, Friedman E, Kim-Sing C, Ainsworth P, Rosen B, Domchek S, Wagner T, Tung N, Manoukian S, Couch F, Sun P, Narod SA (2008) International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers. Int J Cancer 122(9):2017–2022. doi:10.1002/ijc.23340 CrossRefPubMedCentralPubMed Metcalfe KA, Birenbaum-Carmeli D, Lubinski J, Gronwald J, Lynch H, Moller P, Ghadirian P, Foulkes WD, Klijn J, Friedman E, Kim-Sing C, Ainsworth P, Rosen B, Domchek S, Wagner T, Tung N, Manoukian S, Couch F, Sun P, Narod SA (2008) International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers. Int J Cancer 122(9):2017–2022. doi:10.​1002/​ijc.​23340 CrossRefPubMedCentralPubMed

go back to reference Metcalfe KA, Lubinski J, Ghadirian P, Lynch H, Kim-Sing C, Friedman E, Foulkes WD, Domchek S, Ainsworth P, Isaacs C, Tung N, Gronwald J, Cummings S, Wagner T, Manoukian S, Moller P, Weitzel J, Sun P, Narod SA (2008) Predictors of contralateral prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation: the Hereditary Breast Cancer Clinical Study Group. J Clin Oncol 26(7):1093–1097. doi:10.1200/JCO.2007.12.6078 CrossRefPubMed Metcalfe KA, Lubinski J, Ghadirian P, Lynch H, Kim-Sing C, Friedman E, Foulkes WD, Domchek S, Ainsworth P, Isaacs C, Tung N, Gronwald J, Cummings S, Wagner T, Manoukian S, Moller P, Weitzel J, Sun P, Narod SA (2008) Predictors of contralateral prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation: the Hereditary Breast Cancer Clinical Study Group. J Clin Oncol 26(7):1093–1097. doi:10.​1200/​JCO.​2007.​12.​6078 CrossRefPubMed

go back to reference Metcalfe KA, Kim-Sing C, Ghadirian P, Sun P, Narod SA (2014) Health care provider recommendations for reducing cancer risks among women with a BRCA1 or BRCA2 mutation. Clin Genet 85(1):21–30. doi:10.1111/cge.12233 CrossRefPubMed Metcalfe KA, Kim-Sing C, Ghadirian P, Sun P, Narod SA (2014) Health care provider recommendations for reducing cancer risks among women with a BRCA1 or BRCA2 mutation. Clin Genet 85(1):21–30. doi:10.​1111/​cge.​12233 CrossRefPubMed

go back to reference Narod S, Lynch H, Conway T, Watson P, Feunteun J, Lenoir G (1993) Increasing incidence of breast cancer in family with BRCA1 mutation. Lancet 341(8852):1101–1102CrossRefPubMed Narod S, Lynch H, Conway T, Watson P, Feunteun J, Lenoir G (1993) Increasing incidence of breast cancer in family with BRCA1 mutation. Lancet 341(8852):1101–1102CrossRefPubMed

go back to reference King MC, Marks JH, Mandell JB (2003) Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 302(5645):643–646. doi:10.1126/science.1088759 CrossRefPubMed King MC, Marks JH, Mandell JB (2003) Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 302(5645):643–646. doi:10.​1126/​science.​1088759 CrossRefPubMed

go back to reference Foulkes WD, Brunet JS, Wong N, Goffin J, Chappuis PO (2002) Change in the penetrance of founder BRCA1/2 mutations? A retrospective cohort study. J Med Genet 39(6):407–409CrossRefPubMedCentralPubMed Foulkes WD, Brunet JS, Wong N, Goffin J, Chappuis PO (2002) Change in the penetrance of founder BRCA1/2 mutations? A retrospective cohort study. J Med Genet 39(6):407–409CrossRefPubMedCentralPubMed

go back to reference Kotsopoulos J, Narod SA (2005) Towards a dietary prevention of hereditary breast cancer. Cancer Causes Control 16(2):125–138. doi:10.1007/s10552-004-2593-8 CrossRefPubMed Kotsopoulos J, Narod SA (2005) Towards a dietary prevention of hereditary breast cancer. Cancer Causes Control 16(2):125–138. doi:10.​1007/​s10552-004-2593-8 CrossRefPubMed

go back to reference Chang-Claude J, Becher H, Eby N, Bastert G, Wahrendorf J, Hamann U (1997) Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers. J Cancer Res Clin Oncol 123(5):272–279PubMed Chang-Claude J, Becher H, Eby N, Bastert G, Wahrendorf J, Hamann U (1997) Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers. J Cancer Res Clin Oncol 123(5):272–279PubMed

go back to reference Kotsopoulos J, Olopado OI, Ghadirian P, Lubinski J, Lynch HT, Isaacs C, Weber B, Kim-Sing C, Ainsworth P, Foulkes WD, Eisen A, Sun P, Narod SA (2005) Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 7(5):R833–R843. doi:10.1186/bcr1293 CrossRefPubMedCentralPubMed Kotsopoulos J, Olopado OI, Ghadirian P, Lubinski J, Lynch HT, Isaacs C, Weber B, Kim-Sing C, Ainsworth P, Foulkes WD, Eisen A, Sun P, Narod SA (2005) Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 7(5):R833–R843. doi:10.​1186/​bcr1293 CrossRefPubMedCentralPubMed

go back to reference McGee J, Kotsopoulos J, Lubinski J, Lynch HT, Rosen B, Tung N, Kim-Sing C, Karlan B, Foulkes WD, Ainsworth P, Ghadirian P, Senter L, Eisen A, Sun P, Narod SA (2012) Anthropometric measures and risk of ovarian cancer among BRCA1 and BRCA2 mutation carriers. Obesity (Silver Spring) 20(6):1288–1292. doi:10.1038/oby.2011.394 CrossRef McGee J, Kotsopoulos J, Lubinski J, Lynch HT, Rosen B, Tung N, Kim-Sing C, Karlan B, Foulkes WD, Ainsworth P, Ghadirian P, Senter L, Eisen A, Sun P, Narod SA (2012) Anthropometric measures and risk of ovarian cancer among BRCA1 and BRCA2 mutation carriers. Obesity (Silver Spring) 20(6):1288–1292. doi:10.​1038/​oby.​2011.​394 CrossRef

go back to reference Nkondjock A, Robidoux A, Paredes Y, Narod SA, Ghadirian P (2006) Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. Breast Cancer Res Treat 98(3):285–294. doi:10.1007/s10549-006-9161-8 CrossRefPubMed Nkondjock A, Robidoux A, Paredes Y, Narod SA, Ghadirian P (2006) Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. Breast Cancer Res Treat 98(3):285–294. doi:10.​1007/​s10549-006-9161-8 CrossRefPubMed

go back to reference Manders P, Pijpe A, Hooning MJ, Kluijt I, Vasen HF, Hoogerbrugge N, van Asperen CJ, Meijers-Heijboer H, Ausems MG, van Os TA, Gomez-Garcia EB, Brohet RM, van Leeuwen FE, Rookus MA (2011) Body weight and risk of breast cancer in BRCA1/2 mutation carriers. Breast Cancer Res Treat 126(1):193–202. doi:10.1007/s10549-010-1120-8 CrossRefPubMed Manders P, Pijpe A, Hooning MJ, Kluijt I, Vasen HF, Hoogerbrugge N, van Asperen CJ, Meijers-Heijboer H, Ausems MG, van Os TA, Gomez-Garcia EB, Brohet RM, van Leeuwen FE, Rookus MA (2011) Body weight and risk of breast cancer in BRCA1/2 mutation carriers. Breast Cancer Res Treat 126(1):193–202. doi:10.​1007/​s10549-010-1120-8 CrossRefPubMed

go back to reference Pijpe A, Manders P, Brohet RM, Collee JM, Verhoef S, Vasen HF, Hoogerbrugge N, van Asperen CJ, Dommering C, Ausems MG, Aalfs CM, Gomez-Garcia EB, Hebon Van’t Veer LJ, van Leeuwen FE, Rookus MA (2010) Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers. Breast Cancer Res Treat 120(1):235–244. doi:10.1007/s10549-009-0476-0 CrossRefPubMed Pijpe A, Manders P, Brohet RM, Collee JM, Verhoef S, Vasen HF, Hoogerbrugge N, van Asperen CJ, Dommering C, Ausems MG, Aalfs CM, Gomez-Garcia EB, Hebon Van’t Veer LJ, van Leeuwen FE, Rookus MA (2010) Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers. Breast Cancer Res Treat 120(1):235–244. doi:10.​1007/​s10549-009-0476-0 CrossRefPubMed

go back to reference Salmena L, Narod S (2012) BRCA1 haploinsufficiency: consequences for breast cancer. Womens Health (Lond Engl) 8(2):127–129. doi:10.2217/whe.12.2 CrossRef Salmena L, Narod S (2012) BRCA1 haploinsufficiency: consequences for breast cancer. Womens Health (Lond Engl) 8(2):127–129. doi:10.​2217/​whe.​12.​2 CrossRef

go back to reference Berger AH, Pandolfi PP (2011) Haplo-insufficiency: a driving force in cancer. J Pathol 223(2):137–146. doi:10.1002/path.2800 CrossRefPubMed Berger AH, Pandolfi PP (2011) Haplo-insufficiency: a driving force in cancer. J Pathol 223(2):137–146. doi:10.​1002/​path.​2800 CrossRefPubMed

go back to reference Berger AH, Knudson AG, Pandolfi PP (2011) A continuum model for tumour suppression. Nature 476(7359):163–169. doi:10.1038/nature10275 CrossRefPubMedCentralPubMed Berger AH, Knudson AG, Pandolfi PP (2011) A continuum model for tumour suppression. Nature 476(7359):163–169. doi:10.​1038/​nature10275 CrossRefPubMedCentralPubMed

go back to reference Scott R (2004) DNA double strand break repair and its association with inherited predispositions to breast cancer. Hered Cancer Clin Pract 2(1):37–43CrossRefPubMedCentralPubMed Scott R (2004) DNA double strand break repair and its association with inherited predispositions to breast cancer. Hered Cancer Clin Pract 2(1):37–43CrossRefPubMedCentralPubMed

go back to reference Huen MS, Sy SM, Chen J (2010) BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol 11(2):138–148. doi:10.1038/nrm2831 CrossRefPubMedCentralPubMed Huen MS, Sy SM, Chen J (2010) BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol 11(2):138–148. doi:10.​1038/​nrm2831 CrossRefPubMedCentralPubMed

go back to reference Narod SA, Foulkes WD (2004) BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 4(9):665–676. doi:10.1038/nrc1431 CrossRefPubMed Narod SA, Foulkes WD (2004) BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 4(9):665–676. doi:10.​1038/​nrc1431 CrossRefPubMed

go back to reference Schlacher K, Wu H, Jasin M (2012) A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell 22(1):106–116. doi:10.1016/j.ccr.2012.05.015 CrossRefPubMedCentralPubMed Schlacher K, Wu H, Jasin M (2012) A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell 22(1):106–116. doi:10.​1016/​j.​ccr.​2012.​05.​015 CrossRefPubMedCentralPubMed

go back to reference Foulkes WD, Shuen AY (2013) In brief: BRCA1 and BRCA2. J Pathol 230(4):347–349. doi:10.1002/path.4205 CrossRefPubMed Foulkes WD, Shuen AY (2013) In brief: BRCA1 and BRCA2. J Pathol 230(4):347–349. doi:10.​1002/​path.​4205 CrossRefPubMed

go back to reference Silver DP, Livingston DM (2012) Mechanisms of BRCA1 tumor suppression. Cancer Discov 2(8):679–684. doi:10.1158/2159-8290.CD-12-0221 CrossRefPubMedCentralPubMed Silver DP, Livingston DM (2012) Mechanisms of BRCA1 tumor suppression. Cancer Discov 2(8):679–684. doi:10.​1158/​2159-8290.​CD-12-0221 CrossRefPubMedCentralPubMed

go back to reference Friedenreich CM, Neilson HK, Lynch BM (2010) State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer 46(14):2593–2604. doi:10.1016/j.ejca.2010.07.028 CrossRefPubMed Friedenreich CM, Neilson HK, Lynch BM (2010) State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer 46(14):2593–2604. doi:10.​1016/​j.​ejca.​2010.​07.​028 CrossRefPubMed

go back to reference Olsen CM, Green AC, Whiteman DC, Sadeghi S, Kolahdooz F, Webb PM (2007) Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J Cancer 43(4):690–709. doi:10.1016/j.ejca.2006.11.010 CrossRefPubMed Olsen CM, Green AC, Whiteman DC, Sadeghi S, Kolahdooz F, Webb PM (2007) Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J Cancer 43(4):690–709. doi:10.​1016/​j.​ejca.​2006.​11.​010 CrossRefPubMed

go back to reference Wu Y, Zhang D, Kang S (2013) Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat 137(3):869–882. doi:10.1007/s10549-012-2396-7 CrossRefPubMed Wu Y, Zhang D, Kang S (2013) Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat 137(3):869–882. doi:10.​1007/​s10549-012-2396-7 CrossRefPubMed

go back to reference Amadou A, Ferrari P, Muwonge R, Moskal A, Biessy C, Romieu I, Hainaut P (2013) Overweight, obesity and risk of premenopausal breast cancer according to ethnicity: a systematic review and dose-response meta-analysis. Obes Rev 14(8):665–678. doi:10.1111/obr.12028 CrossRefPubMed Amadou A, Ferrari P, Muwonge R, Moskal A, Biessy C, Romieu I, Hainaut P (2013) Overweight, obesity and risk of premenopausal breast cancer according to ethnicity: a systematic review and dose-response meta-analysis. Obes Rev 14(8):665–678. doi:10.​1111/​obr.​12028 CrossRefPubMed

go back to reference Amadou A, Hainaut P, Romieu I (2013) Role of obesity in the risk of breast cancer: lessons from anthropometry. J Oncol 2013:906495. doi:10.1155/2013/906495 CrossRefPubMedCentralPubMed Amadou A, Hainaut P, Romieu I (2013) Role of obesity in the risk of breast cancer: lessons from anthropometry. J Oncol 2013:906495. doi:10.​1155/​2013/​906495 CrossRefPubMedCentralPubMed

go back to reference Olsen CM, Bain CJ, Jordan SJ, Nagle CM, Green AC, Whiteman DC, Webb PM (2007) Recreational physical activity and epithelial ovarian cancer: a case–control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev 16(11):2321–2330. doi:10.1158/1055-9965.EPI-07-0566 CrossRefPubMed Olsen CM, Bain CJ, Jordan SJ, Nagle CM, Green AC, Whiteman DC, Webb PM (2007) Recreational physical activity and epithelial ovarian cancer: a case–control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev 16(11):2321–2330. doi:10.​1158/​1055-9965.​EPI-07-0566 CrossRefPubMed

go back to reference Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579–591. doi:10.1038/nrc1408 CrossRefPubMed Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4(8):579–591. doi:10.​1038/​nrc1408 CrossRefPubMed

go back to reference Chen WY, Colditz GA (2007) Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancer. Nat Clin Pract Oncol 4(7):415–423. doi:10.1038/ncponc0851 CrossRefPubMed Chen WY, Colditz GA (2007) Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancer. Nat Clin Pract Oncol 4(7):415–423. doi:10.​1038/​ncponc0851 CrossRefPubMed

go back to reference Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP, Sherman ME (2004) Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomarkers Prev 13(10):1558–1568PubMed Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP, Sherman ME (2004) Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomarkers Prev 13(10):1558–1568PubMed

go back to reference Suzuki R, Orsini N, Saji S, Key TJ, Wolk A (2009) Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status–a meta-analysis. Int J Cancer 124(3):698–712. doi:10.1002/ijc.23943 CrossRefPubMed Suzuki R, Orsini N, Saji S, Key TJ, Wolk A (2009) Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status–a meta-analysis. Int J Cancer 124(3):698–712. doi:10.​1002/​ijc.​23943 CrossRefPubMed

go back to reference Carmichael AR, Bates T (2004) Obesity and breast cancer: a review of the literature. Breast 13(2):85–92. doi:10.1016/j.breast.2003.03.001 CrossRefPubMed Carmichael AR, Bates T (2004) Obesity and breast cancer: a review of the literature. Breast 13(2):85–92. doi:10.​1016/​j.​breast.​2003.​03.​001 CrossRefPubMed

go back to reference Research WCRFAIfC (2007) Food, nutrition, physical activity and the prevention of cancer: a global perspective. Washington, DC Research WCRFAIfC (2007) Food, nutrition, physical activity and the prevention of cancer: a global perspective. Washington, DC

go back to reference Cancer IAfRo (2002) Weight control and physical activity. IARC handbooks on cancer prevention, vol 6. Lyon, France Cancer IAfRo (2002) Weight control and physical activity. IARC handbooks on cancer prevention, vol 6. Lyon, France

go back to reference van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ (2000) Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 152(6):514–527CrossRefPubMed van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ (2000) Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 152(6):514–527CrossRefPubMed

go back to reference Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578. doi:10.1016/S0140-6736(08)60269-X CrossRefPubMed Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578. doi:10.​1016/​S0140-6736(08)60269-X CrossRefPubMed

go back to reference Potischman N, Swanson CA, Siiteri P, Hoover RN (1996) Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status. J Natl Cancer Inst 88(11):756–758CrossRefPubMed Potischman N, Swanson CA, Siiteri P, Hoover RN (1996) Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status. J Natl Cancer Inst 88(11):756–758CrossRefPubMed

go back to reference Pierobon M, Frankenfeld CL (2013) Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis. Breast Cancer Res Treat 137(1):307–314. doi:10.1007/s10549-012-2339-3 CrossRefPubMed Pierobon M, Frankenfeld CL (2013) Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis. Breast Cancer Res Treat 137(1):307–314. doi:10.​1007/​s10549-012-2339-3 CrossRefPubMed

go back to reference Friedenreich CM, Cust AE (2008) Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med 42(8):636–647. doi:10.1136/bjsm.2006.029132 CrossRefPubMed Friedenreich CM, Cust AE (2008) Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med 42(8):636–647. doi:10.​1136/​bjsm.​2006.​029132 CrossRefPubMed

go back to reference Lynch BM, Neilson HK, Friedenreich CM (2011) Physical activity and breast cancer prevention. Recent Results Cancer Res 186:13–42. doi:10.1007/978-3-642-04231-7_2 CrossRefPubMed Lynch BM, Neilson HK, Friedenreich CM (2011) Physical activity and breast cancer prevention. Recent Results Cancer Res 186:13–42. doi:10.​1007/​978-3-642-04231-7_​2 CrossRefPubMed

go back to reference Phipps AI, Chlebowski RT, Prentice R, McTiernan A, Stefanick ML, Wactawski-Wende J, Kuller LH, Adams-Campbell LL, Lane D, Vitolins M, Kabat GC, Rohan TE, Li CI (2011) Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. Cancer Epidemiol Biomarkers Prev 20(3):454–463. doi:10.1158/1055-9965.EPI-10-0974 CrossRefPubMedCentralPubMed Phipps AI, Chlebowski RT, Prentice R, McTiernan A, Stefanick ML, Wactawski-Wende J, Kuller LH, Adams-Campbell LL, Lane D, Vitolins M, Kabat GC, Rohan TE, Li CI (2011) Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. Cancer Epidemiol Biomarkers Prev 20(3):454–463. doi:10.​1158/​1055-9965.​EPI-10-0974 CrossRefPubMedCentralPubMed

go back to reference Friedenreich CM, Orenstein MR (2002) Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 132(11 Suppl):3456S–3464SPubMed Friedenreich CM, Orenstein MR (2002) Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 132(11 Suppl):3456S–3464SPubMed

go back to reference Neilson HK, Conroy SM, Friedenreich CM (2014) The influence of energetic factors on biomarkers of postmenopausal breast cancer risk. Curr Nutr Rep 3:22–34. doi:10.1007/s13668-013-0069-8 CrossRefPubMedCentralPubMed Neilson HK, Conroy SM, Friedenreich CM (2014) The influence of energetic factors on biomarkers of postmenopausal breast cancer risk. Curr Nutr Rep 3:22–34. doi:10.​1007/​s13668-013-0069-8 CrossRefPubMedCentralPubMed

go back to reference Roberts DL, Dive C, Renehan AG (2010) Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 61:301–316. doi:10.1146/annurev.med.080708.082713 CrossRefPubMed Roberts DL, Dive C, Renehan AG (2010) Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 61:301–316. doi:10.​1146/​annurev.​med.​080708.​082713 CrossRefPubMed

go back to reference Lukanova A, Kaaks R (2005) Endogenous hormones and ovarian cancer: epidemiology and current hypotheses. Cancer Epidemiol Biomarkers Prev 14(1):98–107PubMed Lukanova A, Kaaks R (2005) Endogenous hormones and ovarian cancer: epidemiology and current hypotheses. Cancer Epidemiol Biomarkers Prev 14(1):98–107PubMed

go back to reference Risch HA (1998) Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone.[comment]. J Natl Cancer Inst 90(23):1774–1786CrossRefPubMed Risch HA (1998) Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone.[comment]. J Natl Cancer Inst 90(23):1774–1786CrossRefPubMed

go back to reference Olsen CM, Green AC, Nagle CM, Jordan SJ, Whiteman DC, Bain CJ, Webb PM (2008) Epithelial ovarian cancer: testing the ‘androgens hypothesis’. Endocr Relat Cancer 15(4):1061–1068. doi:10.1677/ERC-08-0075 CrossRefPubMed Olsen CM, Green AC, Nagle CM, Jordan SJ, Whiteman DC, Bain CJ, Webb PM (2008) Epithelial ovarian cancer: testing the ‘androgens hypothesis’. Endocr Relat Cancer 15(4):1061–1068. doi:10.​1677/​ERC-08-0075 CrossRefPubMed

go back to reference Wang M, Yu B, Westerlind K, Strange R, Khan G, Patil D, Boeneman K, Hilakivi-Clarke L (2009) Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland. Breast Cancer Res Treat 115(1):213–220. doi:10.1007/s10549-008-0062-x CrossRefPubMed Wang M, Yu B, Westerlind K, Strange R, Khan G, Patil D, Boeneman K, Hilakivi-Clarke L (2009) Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland. Breast Cancer Res Treat 115(1):213–220. doi:10.​1007/​s10549-008-0062-x CrossRefPubMed

go back to reference Magbanua MJ, Richman EL, Sosa EV, Jones LW, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM (2014) Physical activity and prostate gene expression in men with low-risk prostate cancer. Cancer Causes Control : CCC 25(4):515–523. doi:10.1007/s10552-014-0354-x CrossRefPubMed Magbanua MJ, Richman EL, Sosa EV, Jones LW, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM (2014) Physical activity and prostate gene expression in men with low-risk prostate cancer. Cancer Causes Control : CCC 25(4):515–523. doi:10.​1007/​s10552-014-0354-x CrossRefPubMed

go back to reference Kossman DA, Williams NI, Domchek SM, Kurzer MS, Stopfer JE (1985) Schmitz KH (2011) Exercise lowers estrogen and progesterone levels in premenopausal women at high risk of breast cancer. J Appl Physiol 111(6):1687–1693. doi:10.1152/japplphysiol.00319.2011 CrossRef Kossman DA, Williams NI, Domchek SM, Kurzer MS, Stopfer JE (1985) Schmitz KH (2011) Exercise lowers estrogen and progesterone levels in premenopausal women at high risk of breast cancer. J Appl Physiol 111(6):1687–1693. doi:10.​1152/​japplphysiol.​00319.​2011 CrossRef

go back to reference Guinan EM, Hussey J, McGarrigle SA, Healy LA, O’Sullivan JN, Bennett K, Connolly EM (2013) A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers. BMC Cancer 13:138. doi:10.1186/1471-2407-13-138 CrossRefPubMedCentralPubMed Guinan EM, Hussey J, McGarrigle SA, Healy LA, O’Sullivan JN, Bennett K, Connolly EM (2013) A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers. BMC Cancer 13:138. doi:10.​1186/​1471-2407-13-138 CrossRefPubMedCentralPubMed

go back to reference Pasanisi P, Bruno E, Manoukian S, Berrino F (2014) A randomized controlled trial of diet and physical activity in BRCA mutation carriers. Fam Cancer 13(2):181–187. doi:10.1007/s10689-013-9691-2 CrossRefPubMed Pasanisi P, Bruno E, Manoukian S, Berrino F (2014) A randomized controlled trial of diet and physical activity in BRCA mutation carriers. Fam Cancer 13(2):181–187. doi:10.​1007/​s10689-013-9691-2 CrossRefPubMed

go back to reference Trichopoulos D, Adami HO, Ekbom A, Hsieh CC, Lagiou P (2008) Early life events and conditions and breast cancer risk: from epidemiology to etiology. Int J Cancer 122(3):481–485. doi:10.1002/ijc.23303 CrossRefPubMed Trichopoulos D, Adami HO, Ekbom A, Hsieh CC, Lagiou P (2008) Early life events and conditions and breast cancer risk: from epidemiology to etiology. Int J Cancer 122(3):481–485. doi:10.​1002/​ijc.​23303 CrossRefPubMed

go back to reference Trichopoulos D, Lipworth L (1995) Is cancer causation simpler than we thought, but more intractable? Epidemiology 6(4):347–349CrossRefPubMed Trichopoulos D, Lipworth L (1995) Is cancer causation simpler than we thought, but more intractable? Epidemiology 6(4):347–349CrossRefPubMed

go back to reference Trichopoulos D, Lipman RD (1992) Mammary gland mass and breast cancer risk. Epidemiology 3(6):523–526CrossRefPubMed Trichopoulos D, Lipman RD (1992) Mammary gland mass and breast cancer risk. Epidemiology 3(6):523–526CrossRefPubMed

go back to reference Narod SA (2012) A model for breast cancer risk based on stem-cell theory. Curr Oncol 19(1):9–11. doi:10.3747/co.19.1003 CrossRefPubMedCentralPubMed Narod SA (2012) A model for breast cancer risk based on stem-cell theory. Curr Oncol 19(1):9–11. doi:10.​3747/​co.​19.​1003 CrossRefPubMedCentralPubMed

go back to reference Pollak M (2012) The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 12(3):159–169. doi:10.1038/nrc3215 PubMed Pollak M (2012) The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 12(3):159–169. doi:10.​1038/​nrc3215 PubMed

go back to reference Shafrir AL, Zhang X, Poole EM, Hankinson SE, Tworoger SS (2014) The association of reproductive and lifestyle factors with a score of multiple endogenous hormones. Horm Cancer 5(5):324–335. doi:10.1007/s12672-014-0191-0 CrossRefPubMed Shafrir AL, Zhang X, Poole EM, Hankinson SE, Tworoger SS (2014) The association of reproductive and lifestyle factors with a score of multiple endogenous hormones. Horm Cancer 5(5):324–335. doi:10.​1007/​s12672-014-0191-0 CrossRefPubMed

go back to reference Di LJ, Fernandez AG, De Siervi A, Longo DL, Gardner K (2010) Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat Struct Mol Biol 17(12):1406–1413. doi:10.1038/nsmb.1941 CrossRefPubMedCentralPubMed Di LJ, Fernandez AG, De Siervi A, Longo DL, Gardner K (2010) Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat Struct Mol Biol 17(12):1406–1413. doi:10.​1038/​nsmb.​1941 CrossRefPubMedCentralPubMed

go back to reference Mavaddat N, Barrowdale D, Andrulis IL, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, Sinilnikova OM, Southey MC, Terry MB, Goldgar D, O’Malley F, John EM, Janavicius R, Tihomirova L, Hansen TV, Nielsen FC, Osorio A, Stavropoulou A, Benitez J, Manoukian S, Peissel B, Barile M, Volorio S, Pasini B, Dolcetti R, Putignano AL, Ottini L, Radice P, Hamann U, Rashid MU, Hogervorst FB, Kriege M, van der Luijt RB, Peock S, Frost D, Evans DG, Brewer C, Walker L, Rogers MT, Side LE, Houghton C, Weaver J, Godwin AK, Schmutzler RK, Wappenschmidt B, Meindl A, Kast K, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Varon-Mateeva R, Schonbuchner I, Gevensleben H, Stoppa-Lyonnet D, Belotti M, Barjhoux L, Isaacs C, Peshkin BN, Caldes T, de la Hoya M, Canadas C, Heikkinen T, Heikkila P, Aittomaki K, Blanco I, Lazaro C, Brunet J, Agnarsson BA, Arason A, Barkardottir RB, Dumont M, Simard J, Montagna M, Agata S, D’Andrea E, Yan M, Fox S, Rebbeck TR, Rubinstein W, Tung N, Garber JE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet MM, Singer CF, Tea MK, Rappaport C, Mai PL, Greene MH, Sokolenko A, Imyanitov E, Toland AE, Senter L, Sweet K, Thomassen M, Gerdes AM, Kruse T, Caligo M, Aretini P, Rantala J, von Wachenfeld A, Henriksson K, Steele L, Neuhausen SL, Nussbaum R, Beattie M, Odunsi K, Sucheston L, Gayther SA, Nathanson K, Gross J, Walsh C, Karlan B, Chenevix-Trench G, Easton DF, Antoniou AC (2012) Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol Biomarkers Prev 21(1):134–147. doi:10.1158/1055-9965.EPI-11-0775 CrossRefPubMedCentralPubMed Mavaddat N, Barrowdale D, Andrulis IL, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, Sinilnikova OM, Southey MC, Terry MB, Goldgar D, O’Malley F, John EM, Janavicius R, Tihomirova L, Hansen TV, Nielsen FC, Osorio A, Stavropoulou A, Benitez J, Manoukian S, Peissel B, Barile M, Volorio S, Pasini B, Dolcetti R, Putignano AL, Ottini L, Radice P, Hamann U, Rashid MU, Hogervorst FB, Kriege M, van der Luijt RB, Peock S, Frost D, Evans DG, Brewer C, Walker L, Rogers MT, Side LE, Houghton C, Weaver J, Godwin AK, Schmutzler RK, Wappenschmidt B, Meindl A, Kast K, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Varon-Mateeva R, Schonbuchner I, Gevensleben H, Stoppa-Lyonnet D, Belotti M, Barjhoux L, Isaacs C, Peshkin BN, Caldes T, de la Hoya M, Canadas C, Heikkinen T, Heikkila P, Aittomaki K, Blanco I, Lazaro C, Brunet J, Agnarsson BA, Arason A, Barkardottir RB, Dumont M, Simard J, Montagna M, Agata S, D’Andrea E, Yan M, Fox S, Rebbeck TR, Rubinstein W, Tung N, Garber JE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet MM, Singer CF, Tea MK, Rappaport C, Mai PL, Greene MH, Sokolenko A, Imyanitov E, Toland AE, Senter L, Sweet K, Thomassen M, Gerdes AM, Kruse T, Caligo M, Aretini P, Rantala J, von Wachenfeld A, Henriksson K, Steele L, Neuhausen SL, Nussbaum R, Beattie M, Odunsi K, Sucheston L, Gayther SA, Nathanson K, Gross J, Walsh C, Karlan B, Chenevix-Trench G, Easton DF, Antoniou AC (2012) Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol Biomarkers Prev 21(1):134–147. doi:10.​1158/​1055-9965.​EPI-11-0775 CrossRefPubMedCentralPubMed

go back to reference Digianni LM, Rue M, Emmons K, Garber JE (2006) Complementary medicine use before and 1 year following genetic testing for BRCA1/2 mutations. Cancer Epidemiol Biomarkers Prev 15(1):70–75. doi:10.1158/1055-9965.EPI-05-0646 CrossRefPubMed Digianni LM, Rue M, Emmons K, Garber JE (2006) Complementary medicine use before and 1 year following genetic testing for BRCA1/2 mutations. Cancer Epidemiol Biomarkers Prev 15(1):70–75. doi:10.​1158/​1055-9965.​EPI-05-0646 CrossRefPubMed

go back to reference Emmons KM, Kalkbrenner KJ, Klar N, Light T, Schneider KA, Garber JE (2000) Behavioral risk factors among women presenting for genetic testing. Cancer Epidemiol Biomarkers Prev 9(1):89–94PubMed Emmons KM, Kalkbrenner KJ, Klar N, Light T, Schneider KA, Garber JE (2000) Behavioral risk factors among women presenting for genetic testing. Cancer Epidemiol Biomarkers Prev 9(1):89–94PubMed

go back to reference Spector D (2007) Lifestyle behaviors in women with a BRCA1 or BRCA2 genetic mutation: an exploratory study guided by concepts derived from the health belief model. Cancer Nurs 30(1):E1–10CrossRefPubMed Spector D (2007) Lifestyle behaviors in women with a BRCA1 or BRCA2 genetic mutation: an exploratory study guided by concepts derived from the health belief model. Cancer Nurs 30(1):E1–10CrossRefPubMed

go back to reference O’Neill SC, Kaufman E, DeMarco T, Peshkin BN, McKenna K, Shelby R, Valdimarsdottir H, Rispoli J, Schwartz MD (2008) Changes in diet and physical activity following BRCA1/2 testing. J Psychosoc Oncol 26(3):63–80CrossRefPubMed O’Neill SC, Kaufman E, DeMarco T, Peshkin BN, McKenna K, Shelby R, Valdimarsdottir H, Rispoli J, Schwartz MD (2008) Changes in diet and physical activity following BRCA1/2 testing. J Psychosoc Oncol 26(3):63–80CrossRefPubMed

go back to reference Quach J, Porter K, Leventhal H, Kelly KM (2009) Health behaviors among Ashkenazi Jewish individuals receiving counseling for BRCA1 and BRCA2 mutations. Fam Cancer 8(3):241–250. doi:10.1007/s10689-009-9235-y CrossRefPubMed Quach J, Porter K, Leventhal H, Kelly KM (2009) Health behaviors among Ashkenazi Jewish individuals receiving counseling for BRCA1 and BRCA2 mutations. Fam Cancer 8(3):241–250. doi:10.​1007/​s10689-009-9235-y CrossRefPubMed

go back to reference Pasanisi P, Bruno E, Venturelli E, Manoukian S, Barile M, Peissel B, De Giacomi C, Bonanni B, Berrino J, Berrino F (2011) Serum levels of IGF-I and BRCA penetrance: a case–control study in breast cancer families. Fam Cancer. doi:10.1007/s10689-011-9437-y PubMed Pasanisi P, Bruno E, Venturelli E, Manoukian S, Barile M, Peissel B, De Giacomi C, Bonanni B, Berrino J, Berrino F (2011) Serum levels of IGF-I and BRCA penetrance: a case–control study in breast cancer families. Fam Cancer. doi:10.​1007/​s10689-011-9437-y PubMed