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Systematic Reviews
Published in: Systematic Reviews 1/2017

Open Access 01-12-2017 | Research

The risk associated with spinal manipulation: an overview of reviews

Authors: Sabrina Mai Nielsen, Simon Tarp, Robin Christensen, Henning Bliddal, Louise Klokker, Marius Henriksen

Published in: Systematic Reviews | Issue 1/2017

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Abstract

Background

Spinal manipulative therapy (SMT) is a widely used manual treatment, but many reviews exist with conflicting conclusions about the safety of SMT. We performed an overview of reviews to elucidate and quantify the risk of serious adverse events (SAEs) associated with SMT.

Methods

We searched five electronic databases from inception to December 8, 2015. We included reviews on any type of studies, patients, and SMT technique. Our primary outcome was SAEs. Quality of the included reviews was assessed using a measurement tool to assess systematic reviews (AMSTAR). Since there were insufficient data for calculating incidence rates of SAEs, we used an alternative approach; the conclusions regarding safety of SMT were extracted for each review, and the communicated opinion were judged by two reviewers independently as safe, harmful, or neutral/unclear. Risk ratios (RRs) of a review communicating that SMT is safe and meeting the requirements for each AMSTAR item, were calculated.

Results

We identified 283 eligible reviews, but only 118 provided data for synthesis. The most frequently described adverse events (AEs) were stroke, headache, and vertebral artery dissection. Fifty-four reviews (46%) expressed that SMT is safe, 15 (13%) expressed that SMT is harmful, and 49 reviews (42%) were neutral or unclear. Thirteen reviews reported incidence estimates for SAEs, roughly ranging from 1 in 20,000 to 1 in 250,000,000 manipulations. Low methodological quality was present, with a median of 4 of 11 AMSTAR items met (interquartile range, 3 to 6). Reviews meeting the requirements for each of the AMSTAR items (i.e. good internal validity) had a higher chance of expressing that SMT is safe.

Conclusions

It is currently not possible to provide an overall conclusion about the safety of SMT; however, the types of SAEs reported can indeed be significant, sustaining that some risk is present. High quality research and consistent reporting of AEs and SAEs are needed.

Systematic review registration

PROSPERO CRD42015030068.
Appendix
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Literature
1.
Vernon H, Mrozek J. A revised definition of manipulation. J Manipulative Physiol Ther. 2005;28:68–72.PubMedCrossRef
2.
Brodeur R. The audible release associated with joint manipulation. J Manipulative Physiol Ther. 1995;18:155–64.PubMed
3.
4.
5.
Koes BW, van Tulder M, Lin CW, Macedo LG, McAuley J, Maher C. An updated overview of clinical guidelines for the management of non-specific low back pain in primary care. Eur Spine J. 2010;19:2075–94.PubMedPubMedCentralCrossRef
6.
7.
Hawk C, Schneider M, Ferrance RJ, Hewitt E, Van Loon M, Tanis L. Best practices recommendations for chiropractic care for infants, children, and adolescents: results of a consensus process. J Manipulative Physiol Ther. 2009;32:639–47.PubMedCrossRef
8.
Globe G, Farabaugh RJ, Hawk C, Morris CE, Baker G, Whalen WM, Walters S, Kaeser M, Dehen M, Augat T. Clinical practice guideline: chiropractic care for low back pain. J Manipulative Physiol Ther. 2016;39:1–22.PubMedCrossRef
9.
Bryans R, Decina P, Descarreaux M, Duranleau M, Marcoux H, Potter B, Ruegg RP, Shaw L, Watkin R, White E. Evidence-based guidelines for the chiropractic treatment of adults with neck pain. J Manipulative Physiol Ther. 2014;37:42–63.PubMedCrossRef
10.
Bryans R, Descarreaux M, Duranleau M, Marcoux H, Potter B, Ruegg R, Shaw L, Watkin R, White E. Evidence-based guidelines for the chiropractic treatment of adults with headache. J Manipulative Physiol Ther. 2011;34:274–89.PubMedCrossRef
11.
Hurwitz EL, Chiang LM. A comparative analysis of chiropractic and general practitioner patients in North America: findings from the joint Canada/United States survey of health, 2002-03. BMC Health Serv Res. 2006;6:49.PubMedPubMedCentralCrossRef
12.
Hurwitz EL, Coulter ID, Adams AH, Genovese BJ, Shekelle PG. Use of chiropractic services from 1985 through 1991 in the United States and Canada. Am J Public Health. 1998;88:771–6.PubMedPubMedCentralCrossRef
13.
Hurwitz EL. Epidemiology: spinal manipulation utilization. J Electromyogr Kinesiol. 2012;22:648–54.PubMedCrossRef
14.
Rubinstein Sidney M, van Middelkoop M, Assendelft Willem JJ, de Boer Michiel R, van Tulder Maurits W. Spinal manipulative therapy for chronic low-back pain. Cochrane Database Syst Rev. 2011;(2):CD008112. doi:10.​1002/​14651858.​CD008112.​pub2.
15.
16.
17.
18.
Cagnie B, Vinck E, Beernaert A, Cambier D. How common are side effects of spinal manipulation and can these side effects be predicted? Man Ther. 2004;9:151–6.PubMedCrossRef
19.
Rydell N, Raf L. Spinal manipulation—treatment associated with a high risk of complications. Lakartidningen. 1999;96:3536–40.PubMed
20.
Balblanc JC, Pretot C, Ziegler F. Vascular complication involving the conus medullaris or cauda equina after vertebral manipulation for an L4-L5 disk herniation. Rev Rhum Engl Ed. 1998;65:279–82.PubMed
21.
Peters M, Bohl J, Thomke F, Kallen KJ, Mahlzahn K, Wandel E, Meyer zum Buschenfelde KH. Dissection of the internal carotid artery after chiropractic manipulation of the neck. Neurology. 1995;45:2284–6.PubMedCrossRef
22.
Cortazzo JM, Tom KB. Vertebral artery dissection following chiropractic manipulation. Am J Emerg Med. 1998;16:619–20.PubMedCrossRef
23.
Carlesso LC, Cairney J, Dolovich L, Hoogenes J. Defining adverse events in manual therapy: an exploratory qualitative analysis of the patient perspective. Man Ther. 2011;16:440–6.PubMedCrossRef
24.
Cassidy JD, Boyle E, Cote P, He Y, Hogg-Johnson S, Silver FL, Bondy SJ. Risk of vertebrobasilar stroke and chiropractic care: results of a population-based case-control and case-crossover study. Spine (Phila Pa 1976). 2008;33:S176–183.CrossRef
25.
26.
Smith WS, Johnston SC, Skalabrin EJ, Weaver M, Azari P, Albers GW, Gress DR. Spinal manipulative therapy is an independent risk factor for vertebral artery dissection. Neurology. 2003;60:1424–8.PubMedCrossRef
27.
Zorzela L, Loke YK, Ioannidis JP, Golder S, Santaguida P, Altman DG, Moher D, Vohra S. PRISMA harms checklist: improving harms reporting in systematic reviews. BMJ. 2016;352:i157.PubMedCrossRef
28.
Shea BJ, Hamel C, Wells GA, Bouter LM, Kristjansson E, Grimshaw J, Henry DA, Boers M. AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol. 2009;62:1013–20.PubMedCrossRef
29.
Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, Porter AC, Tugwell P, Moher D, Bouter LM. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10.PubMedPubMedCentralCrossRef
30.
Mickan S, Tilson JK, Atherton H, Roberts NW, Heneghan C. Evidence of effectiveness of health care professionals using handheld computers: a scoping review of systematic reviews. J Med Internet Res. 2013;15:e212.PubMedPubMedCentralCrossRef
31.
Bobrovitz N, Onakpoya I, Roberts N, Heneghan C, Mahtani KR. Protocol for an overview of systematic reviews of interventions to reduce unscheduled hospital admissions among adults. BMJ Open. 2015;5:e008269.PubMedPubMedCentralCrossRef
32.
Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356:1255–9.PubMedCrossRef
33.
Higgins J, Deeks J. Chapter 7.2.6: measuring agreement. In: Higgins JPT, Deeks JJ, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 510 (updated March 2011). 2011.
34.
Xin Z, Xue-Ting L, De-Ying K. GRADE in systematic reviews of acupuncture for stroke rehabilitation: recommendations based on high-quality evidence. Sci Rep. 2015;5:16582.PubMedPubMedCentralCrossRef
35.
36.
Gross A, Langevin P, Burnie SJ, Bedard-Brochu MS, Empey B, Dugas E, Faber-Dobrescu M, Andres C, Graham N, Goldsmith CH, et al. Manipulation and mobilisation for neck pain contrasted against an inactive control or another active treatment. Cochrane Database Syst Rev. 2015;(9):CD004249. doi:10.​1002/​14651858.​CD004249.​pub4.
37.
Page Matthew J, Green S, Kramer S, Johnston Renea V, McBain B, Chau M, Buchbinder R. Manual therapy and exercise for adhesive capsulitis (frozen shoulder). Cochrane Database Syst Rev. 2014;(8):CD011275. doi:10.​1002/​14651858.​CD011275.
38.
39.
Rubinstein SM, Terwee CB, Assendelft WJ, de Boer MR, van Tulder MW. Spinal manipulative therapy for acute low back pain: an update of the cochrane review. Spine (Phila Pa 1976). 2013;38:E158–177.CrossRef
40.
41.
Walker BF, French SD, Grant W, Green S. A Cochrane review of combined chiropractic interventions for low-back pain. Spine (Phila Pa 1976). 2011;36:230–42.CrossRef
42.
Rubinstein SM, van Middelkoop M, Assendelft WJ, de Boer MR, van Tulder MW. Spinal manipulative therapy for chronic low-back pain: an update of a Cochrane review. Spine (Phila Pa 1976). 2011;36:E825–846.CrossRef
43.
44.
45.
Brønfort G, Nilsson N, Haas M, Evans R, Goldsmith CH, Assendelft WJ, Bouter LM. Non-invasive physical treatments for chronic/recurrent headache. Cochrane Database Syst Rev. 2004;(3):CD001878. doi:10.​1002/​14651858.​CD001878.​pub2.
46.
Page Matthew J, Green S, McBain B, Surace Stephen J, Deitch J, Lyttle N, Mrocki Marshall A, Buchbinder R. Manual therapy and exercise for rotator cuff disease. Cochrane Database Syst Rev. 2016;(6):CD012224. doi:10.​1002/​14651858.​CD012224.
47.
Zhu L, Wei X, Wang S. Does cervical spine manipulation reduce pain in people with degenerative cervical radiculopathy? A systematic review of the evidence, and a meta-analysis. Clin Rehabil. 2016;30(2):145–55.PubMedCrossRef
48.
Yuan QL, Guo TM, Liu L, Sun F, Zhang YG. Traditional Chinese medicine for neck pain and low back pain: a systematic review and meta-analysis. PLoS One. 2015;10, e0117146.PubMedPubMedCentralCrossRef
49.
Southerst D, Marchand AA, Cote P, Shearer HM, Wong JJ, Varatharajan S, Randhawa K, Sutton D, Yu H, Gross DP, et al. The effectiveness of noninvasive interventions for musculoskeletal thoracic spine and chest wall pain: a systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. J Manipulative Physiol Ther. 2015;38:521–31.PubMedCrossRef
50.
Sutton DA, Cote P, Wong JJ, Varatharajan S, Randhawa KA, Yu H, Southerst D, Shearer HM, van der Velde GM, Nordin MC, et al. Is multimodal care effective for the management of patients with whiplash-associated disorders or neck pain and associated disorders? A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Spine J. 2016;16(12):1541–65.PubMedCrossRef
51.
Kizhakkeveettil A, Rose K, Kadar GE. Integrative therapies for low back pain that include complementary and alternative medicine care: a systematic review. Glob Adv Health Med. 2014;3:49–64.PubMedPubMedCentralCrossRef
52.
Franke H, Franke JD, Fryer G. Osteopathic manipulative treatment for nonspecific low back pain: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2014;15:286.PubMedPubMedCentralCrossRef
53.
Close C, Sinclair M, Liddle SD, Madden E, McCullough JE, Hughes C. A systematic review investigating the effectiveness of Complementary and Alternative Medicine (CAM) for the management of low back and/or pelvic pain (LBPP) in pregnancy. J Adv Nurs. 2014;70:1702–16.PubMedCrossRef
54.
Schroeder J, Kaplan L, Fischer DJ, Skelly AC. The outcomes of manipulation or mobilization therapy compared with physical therapy or exercise for neck pain: a systematic review. Evid Based Spine Care J. 2013;4:30–41.PubMedPubMedCentralCrossRef
55.
Scholten-Peeters GG, Thoomes E, Konings S, Beijer M, Verkerk K, Koes BW, Verhagen AP. Is manipulative therapy more effective than sham manipulation in adults: a systematic review and meta-analysis. Chiropr Man Therap. 2013;21:34.PubMedPubMedCentralCrossRef
56.
Posadzki P, Lee MS, Ernst E. Osteopathic manipulative treatment for pediatric conditions: a systematic review. Pediatrics. 2013;132:140–52.PubMedCrossRef
57.
Huisman PA, Speksnijder CM, de Wijer A. The effect of thoracic spine manipulation on pain and disability in patients with non-specific neck pain: a systematic review. Disabil Rehabil. 2013;35:1677–85.PubMedCrossRef
58.
Posadzki P, Ernst E. Spinal manipulations for tension-type headaches: a systematic review of randomized controlled trials. Complement Ther Med. 2012;20:232–9.PubMedCrossRef
59.
Lin JH, Chiu TT, Hu J. Chinese manipulation for mechanical neck pain: a systematic review. Clin Rehabil. 2012;26:963–73.PubMedCrossRef
60.
Kuczynski JJ, Schwieterman B, Columber K, Knupp D, Shaub L, Cook CE. Effectiveness of physical therapist administered spinal manipulation for the treatment of low back pain: a systematic review of the literature. Int J Sports Phys Ther. 2012;7:647–62.PubMedPubMedCentral
61.
Posadzki P, Ernst E. Systematic reviews of spinal manipulations for headaches: an attempt to clear up the confusion. Headache. 2011;51:1419–25.PubMedCrossRef
62.
Posadzki P, Ernst E. Spinal manipulations for the treatment of migraine: a systematic review of randomized clinical trials. Cephalalgia. 2011;31:964–70.PubMedCrossRef
63.
Posadzki P, Ernst E. Spinal manipulations for cervicogenic headaches: a systematic review of randomized clinical trials. Headache. 2011;51:1132–9.PubMedCrossRef
64.
Posadzki P, Ernst E. Osteopathy for musculoskeletal pain patients: a systematic review of randomized controlled trials. Clin Rheumatol. 2011;30:285–91.PubMedCrossRef
65.
Cross KM, Kuenze C, Grindstaff TL, Hertel J. Thoracic spine thrust manipulation improves pain, range of motion, and self-reported function in patients with mechanical neck pain: a systematic review. J Orthop Sports Phys Ther. 2011;41:633–42.PubMedCrossRef
66.
Hahne AJ, Ford JJ, McMeeken JM. Conservative management of lumbar disc herniation with associated radiculopathy: a systematic review. Spine (Phila Pa 1976). 2010;35:E488–504.CrossRef
67.
Hunt KJ, Hung SK, Boddy K, Ernst E. Chiropractic manipulation for carpal tunnel syndrome: a systematic review. Hand Therapy. 2009;14:89–94.CrossRef
68.
Vernon H, Humphreys BK. Chronic mechanical neck pain in adults treated by manual therapy: a systematic review of change scores in randomized controlled trials of a single session. J Man Manip Ther. 2008;16:E42–52.PubMedPubMedCentralCrossRef
69.
Vernon H, Humphreys BK. Manual therapy for neck pain: an overview of randomized clinical trials and systematic reviews. Eura Medicophys. 2007;43:91–118.PubMed
70.
Luijsterburg PA, Verhagen AP, Ostelo RW, Os TA, Peul WC, Koes BW. Effectiveness of conservative treatments for the lumbosacral radicular syndrome: a systematic review. Eur Spine J. 2007;16:881–99.PubMedPubMedCentralCrossRef
71.
Gross AR, Goldsmith C, Hoving JL, Haines T, Peloso P, Aker P, Santaguida P, Myers C. Conservative management of mechanical neck disorders: a systematic review. J Rheumatol. 2007;34:1083–102.PubMed
72.
Lenssinck ML, Damen L, Verhagen AP, Berger MY, Passchier J, Koes BW. The effectiveness of physiotherapy and manipulation in patients with tension-type headache: a systematic review. Pain. 2004;112:381–8.PubMedCrossRef
73.
Gross AR, Kay T, Hondras M, Goldsmith C, Haines T, Peloso P, Kennedy C, Hoving J. Manual therapy for mechanical neck disorders: a systematic review. Man Ther. 2002;7:131–49.PubMedCrossRef
74.
Gerritsen AA, Krom MC, Struijs MA, Scholten RJ, Vet HC, Bouter LM. Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials. J Neurol. 2002;249:272–80.PubMedCrossRef
75.
Ernst E, Harkness E. Spinal manipulation: a systematic review of sham-controlled, double-blind, randomized clinical trials. J Pain Symptom Manage. 2001;22:879–89.PubMedCrossRef
76.
Bronfort G, Assendelft WJ, Evans R, Haas M, Bouter L. Efficacy of spinal manipulation for chronic headache: a systematic review. J Manipulative Physiol Ther. 2001;24:457–66.PubMedCrossRef
77.
78.
Vernon H, McDermaid CS, Hagino C. Systematic review of randomized clinical trials of complementary/alternative therapies in the treatment of tension-type and cervicogenic headache. Complement Ther Med. 1999;7:142–55.PubMedCrossRef
79.
Aker PD, Gross AR, Goldsmith CH, Peloso P. Conservative management of mechanical neck pain: systematic overview and meta-analysis. BMJ. 1996;313:1291–6.PubMedPubMedCentralCrossRef
80.
Blanchette MA, Stochkendahl MJ, Borges Da Silva R, Boruff J, Harrison P, Bussieres A. Effectiveness and economic evaluation of chiropractic care for the treatment of low back pain: a systematic review of pragmatic studies. PLoS One. 2016;11, e0160037.PubMedPubMedCentralCrossRef
81.
Cerritelli F, Ruffini N, Lacorte E, Vanacore N. Osteopathic manipulative treatment in neurological diseases: systematic review of the literature. J Neurol Sci. 2016;369:333–41.PubMedCrossRef
82.
Franke H, Franke JD, Fryer G. Osteopathic manipulative treatment for chronic nonspecific neck pain: a systematic review and meta-analysis. Int J Osteopath Med. 2015;18:255–67.CrossRef
83.
Hall H, Cramer H, Sundberg T, Ward L, Adams J, Moore C, Sibbritt D, Lauche R. The effectiveness of complementary manual therapies for pregnancy-related back and pelvic pain: a systematic review with meta-analysis. Medicine (Baltimore). 2016;95, e4723.CrossRef
84.
Ruddock JK, Sallis H, Ness A, Perry RE. Spinal manipulation vs sham manipulation for nonspecific low back pain: a systematic review and meta-analysis. J Chiropr Med. 2016;15:165–83.PubMedPubMedCentralCrossRef
85.
Varatharajan S, Ferguson B, Chrobak K, Shergill Y, Cote P, Wong JJ, Yu H, Shearer HM, Southerst D, Sutton D, et al. Are non-invasive interventions effective for the management of headaches associated with neck pain? An update of the Bone and Joint Decade Task Force on Neck Pain and Its Associated Disorders by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Eur Spine J. 2016;25:1971–99.PubMedCrossRef
86.
Wong JJ, Shearer HM, Mior S, Jacobs C, Cote P, Randhawa K, Yu H, Southerst D, Varatharajan S, Sutton D, et al. Are manual therapies, passive physical modalities, or acupuncture effective for the management of patients with whiplash-associated disorders or neck pain and associated disorders? An update of the Bone and Joint Decade Task Force on Neck Pain and Its Associated Disorders by the OPTIMa collaboration. Spine J. 2016;16:1598–630.PubMedCrossRef
87.
Yao M, Sun YL, Dun RL, Lan TY, Li JL, Lee HJ, Haraguchi N, Wang YJ, Cui XJ. Is manipulative therapy clinically necessary for relief of neck pain? A systematic review and meta-analysis. Chin J Integr Med. 2016. doi:10.​1007/​s11655-016-2506-1.
88.
Carnes D, Mars TS, Mullinger B, Froud R, Underwood M. Adverse events and manual therapy: a systematic review. Man Ther. 2010;15:355–63.PubMedCrossRef
89.
Ernst E. Cerebrovascular complications associated with spinal manipulation. Phys Ther Rev. 2004;9:5–15.CrossRef
90.
Ernst E. Serious adverse effects of unconventional therapies for children and adolescents: a systematic review of recent evidence. Eur J Pediatr. 2003;162:72–80.PubMed
91.
Rubinstein SM, Peerdeman SM, van Tulder MW, Riphagen I, Haldeman S. A systematic review of the risk factors for cervical artery dissection. Stroke. 2005;36:1575–80.PubMedCrossRef
92.
Shekelle PG, Adams AH, Chassin MR, Hurwitz EL, Brook RH. Spinal manipulation for low-back pain. Ann Intern Med. 1992;117:590–8.PubMedCrossRef
93.
Yin P, Gao N, Wu J, Litscher G, Xu S. Adverse events of massage therapy in pain-related conditions: a systematic review. Evid Based Complement Alternat Med. 2014;2014:480956.PubMedPubMedCentral
94.
Khorsan R, Hawk C, Lisi AJ, Kizhakkeveettil A. Manipulative therapy for pregnancy and related conditions: a systematic review. Obstet Gynecol Surv. 2009;64:416–27.PubMedCrossRef
95.
Shin BC, Lee MS, Park TY, Ernst E. Serious adverse events after spinal manipulation: a systematic review of the Korean literature. Focus Altern Complement Ther. 2010;15:198–201.CrossRef
96.
Carlesso LC, Gross AR, Santaguida PL, Burnie S, Voth S, Sadi J. Adverse events associated with the use of cervical manipulation and mobilization for the treatment of neck pain in adults: a systematic review. Man Ther. 2010;15:434–44.PubMedCrossRef
97.
Brantingham JW, Cassa TK, Bonnefin D, Pribicevic M, Robb A, Pollard H, Tong V, Korporaal C. Manipulative and multimodal therapy for upper extremity and temporomandibular disorders: a systematic review. J Manipulative Physiol Ther. 2013;36:143–201.PubMedCrossRef
98.
Todd AJ, Carroll MT, Robinson A, Mitchell EK. Adverse Events Due to Chiropractic and Other Manual Therapies for Infants and Children: A Review of the Literature. J Manipulative Physiol Ther. 2015;38(9):699–712.PubMedCrossRef
99.
Gouveia LO, Castanho P, Ferreira JJ. Safety of chiropractic interventions: a systematic review. Spine (Phila Pa 1976). 2009;34:E405–413.CrossRef
100.
Hawk C, Khorsan R, Lisi AJ, Ferrance RJ, Evans MW. Chiropractic care for nonmusculoskeletal conditions: a systematic review with implications for whole systems research. J Altern Complement Med. 2007;13:491–512.PubMedCrossRef
101.
Clar C, Tsertsvadze A, Court R, Hundt GL, Clarke A, Sutcliffe P. Clinical effectiveness of manual therapy for the management of musculoskeletal and non-musculoskeletal conditions: systematic review and update of UK evidence report. Chiropr Man Therap. 2014;22:12.PubMedPubMedCentralCrossRef
102.
Brantingham JW, Bonnefin D, Perle SM, Cassa TK, Globe G, Pribicevic M, Hicks M, Korporaal C. Manipulative therapy for lower extremity conditions: update of a literature review. J Manipulative Physiol Ther. 2012;35:127–66.PubMedCrossRef
103.
Hebert JJ, Stomski NJ, French SD, Rubinstein SM. Serious Adverse Events and Spinal Manipulative Therapy of the Low Back Region: A Systematic Review of Cases. J Manipulative Physiol Ther. 2015;38(9):677–91.PubMedCrossRef
104.
Brantingham JW, Cassa TK, Bonnefin D, Jensen M, Globe G, Hicks M, Korporaal C. Manipulative therapy for shoulder pain and disorders: expansion of a systematic review. J Manipulative Physiol Ther. 2011;34:314–46.PubMedCrossRef
105.
Young JL, Walker D, Snyder S, Daly K. Thoracic manipulation versus mobilization in patients with mechanical neck pain: a systematic review. J Man Manip Ther. 2014;22:141–53.PubMedPubMedCentralCrossRef
106.
Gleberzon BJ, Arts J, Mei A, McManus EL. The use of spinal manipulative therapy for pediatric health conditions: a systematic review of the literature. J Can Chiropr Assoc. 2012;56:128–41.PubMedPubMedCentral
107.
Stuber KJ, Smith DL. Chiropractic treatment of pregnancy-related low back pain: a systematic review of the evidence. J Manipulative Physiol Ther. 2008;31:447–54.PubMedCrossRef
108.
Kaminskyj A, Frazier M, Johnstone K, Gleberzon BJ. Chiropractic care for patients with asthma: a systematic review of the literature. J Can Chiropr Assoc. 2010;54:24–32.PubMedPubMedCentral
109.
Parkinson L, Sibbritt D, Bolton P, van Rotterdam J, Villadsen I. Well-being outcomes of chiropractic intervention for lower back pain: a systematic review. Clin Rheumatol. 2013;32:167–80.PubMedCrossRef
110.
Reiman MP, Harris JY, Cleland JA. Manual therapy interventions for patients with lumbar spinal stenosis: a systematic review. N Z J Physiother. 2009;37:17–28.
111.
Gemmell H, Miller P. Comparative effectiveness of manipulation, mobilisation and the activator instrument in treatment of non-specific neck pain: a systematic review. Chiropr Osteopat. 2006;14:7.PubMedPubMedCentralCrossRef
112.
Lystad RP, Bell G, Bonnevie-Svendsen M, Carter CV. Manual therapy with and without vestibular rehabilitation for cervicogenic dizziness: a systematic review. Chiropr Man Therap. 2011;19:21.PubMedPubMedCentralCrossRef
113.
Vernon H, Humphreys K, Hagino C. Chronic mechanical neck pain in adults treated by manual therapy: a systematic review of change scores in randomized clinical trials. J Manipulative Physiol Ther. 2007;30:215–27.PubMedCrossRef
114.
Dabbs V, Lauretti WJ. A risk assessment of cervical manipulation vs. NSAIDs for the treatment of neck pain. J Manipulative Physiol Ther. 1995;18:530–6.PubMed
115.
Oliphant D. Safety of spinal manipulation in the treatment of lumbar disk herniations: a systematic review and risk assessment. J Manipulative Physiol Ther. 2004;27:197–210.PubMedCrossRef
116.
117.
Magee DJ, Oborn-Barrett E, Turner S, Fenning N. A systematic overview of the effectiveness of physical therapy intervention on soft tissue neck injury following trauma. Physiotherapy Canada. 2000;52:111–30.
118.
119.
Ernst E. Adverse effects of unconventional therapies in the elderly: a systematic review of the recent literature. J Am Aging Assoc. 2002;25:11–20.PubMedPubMedCentral
120.
Lisi AJ, Holmes EJ, Ammendolia C. High-velocity low-amplitude spinal manipulation for symptomatic lumbar disk disease: a systematic review of the literature. J Manipulative Physiol Ther. 2005;28:429–42.PubMedCrossRef
121.
Fabio RP. Manipulation of the cervical spine: risks and benefits. Phys Ther. 1999;79:50–65.PubMed
122.
Haldeman S, Kohlbeck FJ, McGregor M. Risk factors and precipitating neck movements causing vertebrobasilar artery dissection after cervical trauma and spinal manipulation. Spine (Phila Pa 1976). 1999;24:785–94.CrossRef
123.
Puentedura EJ, March J, Anders J, Perez A, Landers MR, Wallmann HW, Cleland JA. Safety of cervical spine manipulation: are adverse events preventable and are manipulations being performed appropriately? A review of 134 case reports. J Man Manip Ther. 2012;20:66–74.PubMedPubMedCentralCrossRef
124.
125.
Haynes MJ, Vincent K, Fischhoff C, Bremner AP, Lanlo O, Hankey GJ. Assessing the risk of stroke from neck manipulation: a systematic review. Int J Clin Pract. 2012;66:940–7.PubMedPubMedCentralCrossRef
126.
Wynd S, Westaway M, Vohra S, Kawchuk G. The quality of reports on cervical arterial dissection following cervical spinal manipulation. PLoS One. 2013;8:e59170.PubMedPubMedCentralCrossRef
127.
Miley ML, Wellik KE, Wingerchuk DM, Demaerschalk BM. Does cervical manipulative therapy cause vertebral artery dissection and stroke? Neurologist. 2008;14:66–73.PubMedCrossRef
128.
Ernst E. Deaths after chiropractic: a review of published cases. Int J Clin Pract. 2010;64:1162–5.PubMedCrossRef
129.
Ernst E. Prospective investigations into the safety of spinal manipulation. J Pain Symptom Manage. 2001;21:238–42.PubMedCrossRef
130.
Tuchin P. A systematic literature review of intracranial hypotension following chiropractic. Int J Clin Pract. 2014;68:396–402.PubMedCrossRef
131.
Assendelft WJ, Bouter LM, Knipschild PG. Complications of spinal manipulation: a comprehensive review of the literature. J Fam Pract. 1996;42:475–80.PubMed
132.
Stuber KJ, Wynd S, Weis CA. Adverse events from spinal manipulation in the pregnant and postpartum periods: a critical review of the literature. Chiropr Man Therap. 2012;20:8.PubMedPubMedCentralCrossRef
133.
Ernst E. Ophthalmological adverse effects of (chiropractic) upper spinal manipulation: evidence from recent case reports. Acta Ophthalmol Scand. 2005;83:581–5.PubMedCrossRef
134.
135.
Snelling NJ. Spinal manipulation in patients with disc herniation: a critical review of risk and benefit. Int J Osteopath Med. 2006;9:77–84.CrossRef
136.
Ernst E. Manipulation of the cervical spine: a systematic review of case reports of serious adverse events, 1995-2001. Med J Aust. 2002;176:376–80.PubMed
137.
Church EW, Sieg EP, Zalatimo O, Hussain NS, Glantz M, Harbaugh RE. Systematic review and meta-analysis of chiropractic care and cervical artery dissection: no evidence for causation. Cureus. 2016;8, e498.PubMedPubMedCentral
138.
Posadzki P, Albedah AMN, Khalil MMK, Alqaed MS, Lee MS, Ernst E, Car J. Complementary and alternative medicine for the prevention and treatment of migraine headache: an overview of systematic reviews. Focus Altern Complement Ther. 2015;20:58–73.CrossRef
139.
Ruffini N, D'Alessandro G, Cardinali L, Frondaroli F, Cerritelli F. Osteopathic manipulative treatment in gynecology and obstetrics: a systematic review. Complement Ther Med. 2016;26:72–8.PubMedCrossRef
140.
Wearing J, Beaumont S, Forbes D, Brown B, Engel R. The use of spinal manipulative therapy in the management of chronic obstructive pulmonary disease: a systematic review. J Altern Complement Med. 2016;22:108–14.PubMedPubMedCentralCrossRef
141.
Chou R, Huffman L. Evaluation and management of low back pain. Glenview, Illinois: American Pain Society; 2007.
142.
Gross AR, Kay TM, Kennedy C, Gasner D, Hurley L, Yardley K, Hendry L, McLaughlin L. Clinical practice guideline on the use of manipulation or mobilization in the treatment of adults with mechanical neck disorders. Man Ther. 2002;7:193–205.PubMedCrossRef
143.
Chou R, Huffman LH. Nonpharmacologic therapies for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med. 2007;147:492–504.PubMedCrossRef
144.
Coulter ID, Hurwitz E, Adams AH, Meeker W, Hansen DT, Mootz R, Aker P, Genovese B, Shekelle PG. The appropriateness of manipulation and mobilization of the cervical spine. Santa Monica: RAND Corporation; 1996.
145.
Brurberg KG, Myrhaug HT, Reinar LM. Diagnostics and treatment of infant suspected with kinematic imbalance due to suboccipital strain (KISS). In: Rapport fra Kunnskapssenteret nr 17 − 2009. Oslo: The Norwegian Knowledge Centre for the Health Services (NOKC); 2009.
146.
Brown A, Angus D, Chen S, Tang Z, Milne S, Pfaff J, Li H, Mensinkai S. Costs and outcomes of chiropractic treatment for low back pain. In: Health Technology Assessment Database. 2005. p. 88.
147.
Boudreau R, Argaez C. Chiropractic interventions for acute or chronic lower back pain in adults: a review of the clinical and cost-effectiveness. In: Health Technology Assessment Database: Canadian Agency for Drugs and Technologies in Health (CADTH). 2009.
148.
Furlan AD, Yazdi F, Tsertsvadze A, Gross A, Van Tulder M, Santaguida L, Gagnier J, Ammendolia C, Dryden T, Doucette S, et al. A systematic review and meta-analysis of efficacy, cost-effectiveness, and safety of selected complementary and alternative medicine for neck and low-back pain. Evid Based Complement Alternat Med. 2012;2012:953139.PubMedCrossRef
149.
Furlan AD, Yazdi F, Tsertsvadze A, Gross A, Van Tulder M, Santaguida L, Cherkin D, Gagnier J, Ammendolia C, Ansari MT, et al. Complementary and alternative therapies for back pain II. Evidence Report/Technology Assessment No. 194. (Prepared by the University of Ottawa Evidence-based Practice Center under Contract No. 290-2007-10059-I (EPCIII). AHRQ Publication No. 10(11)­ E007. Rockville: Agency for Healthcare Research and Quality; 2010. p. 1-764.
150.
Hurwitz EL, Aker PD, Adams AH, Meeker WC, Shekelle PG. Manipulation and mobilization of the cervical spine. A systematic review of the literature. Spine (Phila Pa 1976). 1996;21:1746–59. discussion 1759-1760.CrossRef
151.
Boudreau R, Spry C. Treatment of hydromyelia in adults: a review of clinical effectiveness and guidelines. In: Health Technology Assessment Database. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH); 2009.
152.
Oduneye F. Spinal manipulation for chronic neck pain. In: Health Technology Assessment Database. 2004. p. 10.
153.
Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, Fu R, Dana T, Kraegel P, Griffin J, et al. Noninvasive treatments for low back pain (Structured abstract). In: Health Technology Assessment Database. Rockville: Agency for Healthcare Research and Quality (AHRQ); 2016.
154.
Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, Fu R, Dana T, Kraegel P, Griffin J, et al. AHRQ comparative effectiveness reviews. In: Noninvasive Treatments for Low Back Pain. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016.
155.
Haldeman S, Kohlbeck FJ, McGregor M. Unpredictability of cerebrovascular ischemia associated with cervical spine manipulation therapy: a review of sixty-four cases after cervical spine manipulation. Spine (Phila Pa 1976). 2002;27:49–55.CrossRef
156.
157.
Hartling L, Vandermeer B, Fernandes RM. Systematic reviews, overviews of reviews and comparative effectiveness reviews: a discussion of approaches to knowledge synthesis. Evid Based Child Health. 2014;9:486–94.PubMedCrossRef
158.
Haldeman S, Carey P, Townsend M, Papadopoulos C. Clinical perceptions of the risk of vertebral artery dissection after cervical manipulation: the effect of referral bias. Spine J. 2003;2:334–42.CrossRef
159.
Zorzela L, Golder S, Liu Y, Pilkington K, Hartling L, Joffe A, Loke Y, Vohra S. Quality of reporting in systematic reviews of adverse events: systematic review. BMJ. 2014;348:f7668.PubMedPubMedCentralCrossRef
160.
Ernst E, Posadzki P. Reporting of adverse effects in randomised clinical trials of chiropractic manipulations: a systematic review. N Z Med J. 2012;125:87–140.PubMed
161.
Tang E, Ravaud P, Riveros C, Perrodeau E, Dechartres A. Comparison of serious adverse events posted at ClinicalTrials.gov and published in corresponding journal articles. BMC Med. 2015;13:189.PubMedPubMedCentralCrossRef
162.
Gorrell LM, Engel RM, Brown B, Lystad RP. The reporting of adverse events following spinal manipulation in randomized clinical trials-a systematic review. Spine J. 2016;16:1143–51.PubMedCrossRef
Metadata
Title
The risk associated with spinal manipulation: an overview of reviews
Authors
Sabrina Mai Nielsen
Simon Tarp
Robin Christensen
Henning Bliddal
Louise Klokker
Marius Henriksen
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2017
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-017-0458-y

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