Skip to main content
Top
Published in: European Spine Journal 7/2007

01-07-2007 | Original Article

Effectiveness of conservative treatments for the lumbosacral radicular syndrome: a systematic review

Authors: Pim A. J. Luijsterburg, Arianne P. Verhagen, Raymond W. J. G. Ostelo, Ton A. G. van Os, Wilco C. Peul, Bart W. Koes

Published in: European Spine Journal | Issue 7/2007

Login to get access

Abstract

Patients with a lumbosacral radicular syndrome are mostly treated conservatively first. The effect of the conservative treatments remains controversial. To assess the effectiveness of conservative treatments of the lumbosacral radicular syndrome (sciatica). Relevant electronic databases and the reference lists of articles up to May 2004 were searched. Randomised clinical trials of all types of conservative treatments for patients with the lumbosacral radicular syndrome selected by two reviewers. Two reviewers independently assessed the methodological quality and the clinical relevance. Because the trials were considered heterogeneous we decided not to perform a meta-analysis but to summarise the results using the rating system of levels of evidence. Thirty trials were included that evaluated injections, traction, physical therapy, bed rest, manipulation, medication, and acupuncture as treatment for the lumbosacral radicular syndrome. Because several trials indicated no evidence of an effect it is not recommended to use corticosteroid injections and traction as treatment option. Whether clinicians should prescribe physical therapy, bed rest, manipulation or medication could not be concluded from this review. At present there is no evidence that one type of treatment is clearly superior to others, including no treatment, for patients with a lumbosacral radicular syndrome.
Literature
1.
go back to reference Berry H, Hutchinson DR (1988) Tizanidine and ibuprofen in acute low-back pain: results of a double-blind multicentre study in general practice. J Int Med Res 16:83–91PubMed Berry H, Hutchinson DR (1988) Tizanidine and ibuprofen in acute low-back pain: results of a double-blind multicentre study in general practice. J Int Med Res 16:83–91PubMed
2.
go back to reference Borms T (1988) Comparison of injectable formulations of tiaprofenic acid and ketoprofen in acute lumbar sciatica. Single-blind randomised trial. Drugs 35(Suppl 1):85–7PubMed Borms T (1988) Comparison of injectable formulations of tiaprofenic acid and ketoprofen in acute lumbar sciatica. Single-blind randomised trial. Drugs 35(Suppl 1):85–7PubMed
3.
go back to reference Buchner M, Zeifang F, Brocai DR, Schiltenwolf M (2000) Epidural corticosteroid injection in the conservative management of sciatica. Clin Orthop 375:149–56PubMedCrossRef Buchner M, Zeifang F, Brocai DR, Schiltenwolf M (2000) Epidural corticosteroid injection in the conservative management of sciatica. Clin Orthop 375:149–56PubMedCrossRef
4.
go back to reference Burton AK, Tillotson KM, Cleary J (2000) Single-blind randomised controlled trial of chemonucleolysis and manipulation in the treatment of symptomatic lumbar disc herniation. Eur Spine J 9:202–207PubMedCrossRef Burton AK, Tillotson KM, Cleary J (2000) Single-blind randomised controlled trial of chemonucleolysis and manipulation in the treatment of symptomatic lumbar disc herniation. Eur Spine J 9:202–207PubMedCrossRef
5.
go back to reference Bush K, Hillier S (1991) A controlled study of caudal epidural injections of triamcinolone plus procaine for the management of intractable sciatica. Spine 16:572–575PubMedCrossRef Bush K, Hillier S (1991) A controlled study of caudal epidural injections of triamcinolone plus procaine for the management of intractable sciatica. Spine 16:572–575PubMedCrossRef
6.
go back to reference Carette S, Leclaire R, Marcoux S, Morin F, Blaise GA, St-Pierre A, Truchon R, Parent F, Levesque J, Bergeron V, Montminy P, Blanchette C (1997) Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. N Engl J Med 336:1634–1640PubMedCrossRef Carette S, Leclaire R, Marcoux S, Morin F, Blaise GA, St-Pierre A, Truchon R, Parent F, Levesque J, Bergeron V, Montminy P, Blanchette C (1997) Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. N Engl J Med 336:1634–1640PubMedCrossRef
7.
go back to reference Coxhead CE, Inskip H, Meade TW, North WR, Troup JD (1981) Multicentre trial of physiotherapy in the management of sciatic symptoms. Lancet 1:1065–1068PubMedCrossRef Coxhead CE, Inskip H, Meade TW, North WR, Troup JD (1981) Multicentre trial of physiotherapy in the management of sciatic symptoms. Lancet 1:1065–1068PubMedCrossRef
8.
go back to reference Cuckler JM, Bernini PA, Wiesel SW, Booth RE Jr, Rothman RH, Pickens GT (1985) The use of epidural steroids in the treatment of lumbar radicular pain. A prospective, randomized, double-blind study. J Bone Joint Surg Am 67:63–66PubMed Cuckler JM, Bernini PA, Wiesel SW, Booth RE Jr, Rothman RH, Pickens GT (1985) The use of epidural steroids in the treatment of lumbar radicular pain. A prospective, randomized, double-blind study. J Bone Joint Surg Am 67:63–66PubMed
10.
go back to reference Dickersin K, Manheimer E, Wieland S, Robinson KA, Lefebvre C, McDonald S (2002) Development of the cochrane collaboration’s CENTRAL register of controlled clinical trials. Eval Health Prof 25:38–64PubMed Dickersin K, Manheimer E, Wieland S, Robinson KA, Lefebvre C, McDonald S (2002) Development of the cochrane collaboration’s CENTRAL register of controlled clinical trials. Eval Health Prof 25:38–64PubMed
11.
go back to reference Dilke TF, Burry HC, Grahame R (1973) Extradural corticosteroid injection in management of lumbar nerve root compression. Br Med J 2:635–637PubMedCrossRef Dilke TF, Burry HC, Grahame R (1973) Extradural corticosteroid injection in management of lumbar nerve root compression. Br Med J 2:635–637PubMedCrossRef
12.
go back to reference Duplan B, Cabanel G, Piton JL, Grauer JL, Phelip X (1983) Acupuncture et lombosciatique a la phase aigue. Etude en double aveugle de trente cas (Acupuncture and sciatica in the acute phase. Double-blind study of 30 cases) . Sem Hop 59:3109–3114PubMed Duplan B, Cabanel G, Piton JL, Grauer JL, Phelip X (1983) Acupuncture et lombosciatique a la phase aigue. Etude en double aveugle de trente cas (Acupuncture and sciatica in the acute phase. Double-blind study of 30 cases) . Sem Hop 59:3109–3114PubMed
13.
go back to reference Health Council of the Netherlands (1999) Management of the lumbosacral radicular syndrome (sciatica). The Hague, publication no. 1999/18 Health Council of the Netherlands (1999) Management of the lumbosacral radicular syndrome (sciatica). The Hague, publication no. 1999/18
14.
go back to reference Helliwell M, Robertson JC, Ellis RM (1985) Outpatient treatment of low back pain and sciatica by a single extradural corticosteriod injection. Br J Clin Pract 39:228–231 Helliwell M, Robertson JC, Ellis RM (1985) Outpatient treatment of low back pain and sciatica by a single extradural corticosteriod injection. Br J Clin Pract 39:228–231
15.
go back to reference Higgins JPT, Green S (eds) (2005) Cochrane handbook for systematic reviews of interventions 4.2.5 (updated May 2005). In: The Cochrane Library, Issue 3. Wiley, Chichester Higgins JPT, Green S (eds) (2005) Cochrane handbook for systematic reviews of interventions 4.2.5 (updated May 2005). In: The Cochrane Library, Issue 3. Wiley, Chichester
16.
go back to reference Hofstee DJ, Gijtenbeek JM, Hoogland PH, van Houwelingen HC, Kloet A, Lotters F, Tans JT (2002) Westeinde sciatica trial: randomized controlled study of bed rest and physiotherapy for acute sciatica. J Neurosurg 96:45–49PubMed Hofstee DJ, Gijtenbeek JM, Hoogland PH, van Houwelingen HC, Kloet A, Lotters F, Tans JT (2002) Westeinde sciatica trial: randomized controlled study of bed rest and physiotherapy for acute sciatica. J Neurosurg 96:45–49PubMed
17.
go back to reference Karppinen J, Malmivaara A, Kurunlahti M, Kyllonen E, Pienimaki T, Nieminen P, Ohinmaa A, Tervonen O, Vanharanta H (2001) Periradicular infiltration for sciatica: a randomized controlled trial. Spine 26:1059–1067PubMedCrossRef Karppinen J, Malmivaara A, Kurunlahti M, Kyllonen E, Pienimaki T, Nieminen P, Ohinmaa A, Tervonen O, Vanharanta H (2001) Periradicular infiltration for sciatica: a randomized controlled trial. Spine 26:1059–1067PubMedCrossRef
18.
go back to reference Klenerman L, Greenwood R, Davenport HT, White DC, Peskett S (1984) Lumbar epidural injections in the treatment of sciatica. Br J Rheumatol 23:35–38PubMedCrossRef Klenerman L, Greenwood R, Davenport HT, White DC, Peskett S (1984) Lumbar epidural injections in the treatment of sciatica. Br J Rheumatol 23:35–38PubMedCrossRef
19.
go back to reference Landis JR, Koch GG (1977) An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics 33:363–374PubMedCrossRef Landis JR, Koch GG (1977) An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics 33:363–374PubMedCrossRef
20.
go back to reference Larsson U, Choler U, Lidstrom A, Lind G, Nachemson A, Nilsson B, Roslund J (1980) Auto-traction for treatment of lumbago-sciatica. A multicentre controlled investigation. Acta Orthop Scand 51:791–798PubMedCrossRef Larsson U, Choler U, Lidstrom A, Lind G, Nachemson A, Nilsson B, Roslund J (1980) Auto-traction for treatment of lumbago-sciatica. A multicentre controlled investigation. Acta Orthop Scand 51:791–798PubMedCrossRef
21.
go back to reference Lidström A, Zachrisson M (1970) Physical therapy on low back pain and sciatica. An attempt at evaluation. Scand J Rehabil Med 2:37–42PubMed Lidström A, Zachrisson M (1970) Physical therapy on low back pain and sciatica. An attempt at evaluation. Scand J Rehabil Med 2:37–42PubMed
22.
go back to reference Ljunggren AE, Weber H, Larsen S (1984) Autotraction versus manual traction in patients with prolapsed lumbar intervertebral discs. Scand J Rehabil Med 16:117–124PubMed Ljunggren AE, Weber H, Larsen S (1984) Autotraction versus manual traction in patients with prolapsed lumbar intervertebral discs. Scand J Rehabil Med 16:117–124PubMed
23.
go back to reference Ljunggren AE, Walker L, Weber H, Amundsen T (1992) Manual traction versus isometric exercises in patients with herniated intervertebral lumbar discs. Physiother Theory Pract 8:207–213 Ljunggren AE, Walker L, Weber H, Amundsen T (1992) Manual traction versus isometric exercises in patients with herniated intervertebral lumbar discs. Physiother Theory Pract 8:207–213
24.
go back to reference Mathews JA, Hickling J (1975) Lumbar traction: a double-blind controlled study for sciatica. Rheumatol Rehabil 14:222–225PubMedCrossRef Mathews JA, Hickling J (1975) Lumbar traction: a double-blind controlled study for sciatica. Rheumatol Rehabil 14:222–225PubMedCrossRef
25.
go back to reference Mathews JA, Mills SB, Jenkins VM, Grimes SM, Morkel MJ, Mathews W, Scott CM, Sittampalam Y (1987) Back pain and sciatica: controlled trials of manipulation, traction, sclerosant and epidural injections. Br J Rheumatol 26:416–423PubMedCrossRef Mathews JA, Mills SB, Jenkins VM, Grimes SM, Morkel MJ, Mathews W, Scott CM, Sittampalam Y (1987) Back pain and sciatica: controlled trials of manipulation, traction, sclerosant and epidural injections. Br J Rheumatol 26:416–423PubMedCrossRef
26.
go back to reference Mens JMA, Chavannes AW, Koes BW, Lubbers WJ, Ostelo RWJG, Spinnewijn WEM, Kolnaar BGM (2005) NHG-Standaard lumbosacraal radiculair syndroom (NHG-guideline lumbosacral radicular syndrome). Huisarts en Wetenschap 48:171–178 Mens JMA, Chavannes AW, Koes BW, Lubbers WJ, Ostelo RWJG, Spinnewijn WEM, Kolnaar BGM (2005) NHG-Standaard lumbosacraal radiculair syndroom (NHG-guideline lumbosacral radicular syndrome). Huisarts en Wetenschap 48:171–178
27.
go back to reference Ostelo RWJG, de Vet HCW, van Tulder MW, Kerckhoffs MR, Leffers P, Wadell G (2002) Rehabilitation after lumbar disc surgery (Protocol for a cochrane review), The Cochrane Library Ostelo RWJG, de Vet HCW, van Tulder MW, Kerckhoffs MR, Leffers P, Wadell G (2002) Rehabilitation after lumbar disc surgery (Protocol for a cochrane review), The Cochrane Library
28.
go back to reference Reust P, Chantraine A, Vischer TL (1988) Traitement par tractions mecaniques des lombosciatalgies avec ou sans deficit neurologique. Une etude en “double aveugle” (Treatment of lumbar sciatica with or without neurological deficit using mechanical traction. A double-blind study). Schweiz Med Wochenschr 118:271–274PubMed Reust P, Chantraine A, Vischer TL (1988) Traitement par tractions mecaniques des lombosciatalgies avec ou sans deficit neurologique. Une etude en “double aveugle” (Treatment of lumbar sciatica with or without neurological deficit using mechanical traction. A double-blind study). Schweiz Med Wochenschr 118:271–274PubMed
29.
go back to reference Ridley MG, Kingsley GH, Gibson T, Grahame R (1988) Outpatient lumbar epidural corticosteroid injection in the management of sciatica. Br J Rheumatol 27:295–299PubMedCrossRef Ridley MG, Kingsley GH, Gibson T, Grahame R (1988) Outpatient lumbar epidural corticosteroid injection in the management of sciatica. Br J Rheumatol 27:295–299PubMedCrossRef
30.
go back to reference Robinson KA, Dickersin K (2002) Development of a highly sensitive search strategy for the retrieval of reports of controlled trials using PubMed. Int J Epidemiol 31:150–153PubMedCrossRef Robinson KA, Dickersin K (2002) Development of a highly sensitive search strategy for the retrieval of reports of controlled trials using PubMed. Int J Epidemiol 31:150–153PubMedCrossRef
31.
go back to reference Rogers P, Nash T, Schiller D, Norman J (1992) Epidural steriods for sciatica. Pain Clin 5:67–72 Rogers P, Nash T, Schiller D, Norman J (1992) Epidural steriods for sciatica. Pain Clin 5:67–72
33.
go back to reference Snoek W, Weber H, Jorgensen B (1977) Double blind evaluation of extradural methyl prednisolone for herniated lumbar discs. Acta Orthop Scand 48:635–641PubMedCrossRef Snoek W, Weber H, Jorgensen B (1977) Double blind evaluation of extradural methyl prednisolone for herniated lumbar discs. Acta Orthop Scand 48:635–641PubMedCrossRef
34.
go back to reference Stam J (1996) Consensus over diagnostiek en behandeling van het lumbosacrale radiculaire syndroom (Consensus in diagnosing and treatment of the lumbosacral radicular syndrome). Ned Tijdschr Geneeskd 140:2621–2627PubMed Stam J (1996) Consensus over diagnostiek en behandeling van het lumbosacrale radiculaire syndroom (Consensus in diagnosing and treatment of the lumbosacral radicular syndrome). Ned Tijdschr Geneeskd 140:2621–2627PubMed
35.
go back to reference Thomas E, Cyteval C, Abiad L, Picot MC, Taourel P, Blotman F (2003) Efficacy of transforaminal versus interspinous corticosteroid injectionin discal radiculalgia—a prospective, randomised, double-blind study. Clin Rheumatol 22:299–304PubMedCrossRef Thomas E, Cyteval C, Abiad L, Picot MC, Taourel P, Blotman F (2003) Efficacy of transforaminal versus interspinous corticosteroid injectionin discal radiculalgia—a prospective, randomised, double-blind study. Clin Rheumatol 22:299–304PubMedCrossRef
36.
go back to reference Van Tulder M, Furlan A, Bombardier C, Bouter L (2003) Updated method guidelines for systematic reviews in the cochrane collaboration back review group. Spine 28:1290–1299PubMedCrossRef Van Tulder M, Furlan A, Bombardier C, Bouter L (2003) Updated method guidelines for systematic reviews in the cochrane collaboration back review group. Spine 28:1290–1299PubMedCrossRef
37.
go back to reference Verhagen AP, de Vet HC, de Bie RA, Boers M, van den Brandt PA (2001) The art of quality assessment of RCTs included in systematic reviews. J Clin Epidemiol 54:651–654PubMedCrossRef Verhagen AP, de Vet HC, de Bie RA, Boers M, van den Brandt PA (2001) The art of quality assessment of RCTs included in systematic reviews. J Clin Epidemiol 54:651–654PubMedCrossRef
38.
go back to reference Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Bouter LM, Knipschild PG (1998) The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol 51:1235–1241PubMedCrossRef Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Bouter LM, Knipschild PG (1998) The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol 51:1235–1241PubMedCrossRef
39.
go back to reference Vroomen PC, de Krom MC, Wilmink JT, Kester AD, Knottnerus JA (1999) Lack of effectiveness of bed rest for sciatica. N Eng J Med 340:418–423CrossRef Vroomen PC, de Krom MC, Wilmink JT, Kester AD, Knottnerus JA (1999) Lack of effectiveness of bed rest for sciatica. N Eng J Med 340:418–423CrossRef
40.
go back to reference Vroomen PC, de Krom MC, Slofstra PD, Knottnerus JA (2000) Conservative treatment of sciatica: a systematic review. J Spinal Disord 13:463–469PubMedCrossRef Vroomen PC, de Krom MC, Slofstra PD, Knottnerus JA (2000) Conservative treatment of sciatica: a systematic review. J Spinal Disord 13:463–469PubMedCrossRef
41.
go back to reference Weber H (1973) Traction therapy in sciatica due to disc prolapse (does traction treatment have any positive effect on patients suffering from sciatica caused by disc prolapse)? J Oslo City Hosp 23:167–176PubMed Weber H (1973) Traction therapy in sciatica due to disc prolapse (does traction treatment have any positive effect on patients suffering from sciatica caused by disc prolapse)? J Oslo City Hosp 23:167–176PubMed
42.
go back to reference Weber H (1983) Lumbar disc herniation. A controlled, prospective study with ten years of observation. Spine 8:131–140PubMedCrossRef Weber H (1983) Lumbar disc herniation. A controlled, prospective study with ten years of observation. Spine 8:131–140PubMedCrossRef
43.
go back to reference Weber H, Holme I, Amlie E (1993) The natural course of acute sciatica with nerve root symptoms in a double-blind placebo-controlled trial evaluating the effect of piroxicam. Spine 18:1433–1438PubMedCrossRef Weber H, Holme I, Amlie E (1993) The natural course of acute sciatica with nerve root symptoms in a double-blind placebo-controlled trial evaluating the effect of piroxicam. Spine 18:1433–1438PubMedCrossRef
44.
go back to reference Weber H, Ljunggren AE, Walker L (1984) Traction therapy in patients with herniated lumbar intervertebral discs. J Oslo City Hosp 34:61–70PubMed Weber H, Ljunggren AE, Walker L (1984) Traction therapy in patients with herniated lumbar intervertebral discs. J Oslo City Hosp 34:61–70PubMed
Metadata
Title
Effectiveness of conservative treatments for the lumbosacral radicular syndrome: a systematic review
Authors
Pim A. J. Luijsterburg
Arianne P. Verhagen
Raymond W. J. G. Ostelo
Ton A. G. van Os
Wilco C. Peul
Bart W. Koes
Publication date
01-07-2007
Publisher
Springer-Verlag
Published in
European Spine Journal / Issue 7/2007
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-007-0367-1

Other articles of this Issue 7/2007

European Spine Journal 7/2007 Go to the issue