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Published in: Oncology and Therapy 2/2018

Open Access 01-12-2018 | Commentary

The Risk Assessment in Low-Grade Gliomas: An Analysis of the European Organization for Research and Treatment of Cancer (EORTC) and the Radiation Therapy Oncology Group (RTOG) criteria

Authors: Andrea Lanese, Enrico Franceschi, Alba A. Brandes

Published in: Oncology and Therapy | Issue 2/2018

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Abstract

Diffuse low-grade gliomas (LGG) are rare tumors that affect young adult patients. The European Organization for Research and Treatment of Cancer (EORTC) and the Radiation Therapy Oncology Group (RTOG) have both developed their own clinical prognostic scores to assist clinicians in treatment decision-making. These criteria have been used to include patients in phase III studies. To date, it is unknown which is the best score to define the prognosis of LGG. Additionally, a pure clinical classification is probably not a sufficiently informative basis for choosing the proper treatment in different situations. A combined score with both clinical and molecular features will likely be indispensable.
Literature
1.
go back to reference Rees J, Watt H, Jäger HR, et al. Volumes and growth rates of untreated adult low-grade gliomas indicate risk of early malignant transformation. Eur J Radiol. 2009;72(1):54–64.CrossRef Rees J, Watt H, Jäger HR, et al. Volumes and growth rates of untreated adult low-grade gliomas indicate risk of early malignant transformation. Eur J Radiol. 2009;72(1):54–64.CrossRef
2.
go back to reference Sahm F, Capper D, Jeibmann A, et al. Addressing diffuse glioma as a systemic brain disease with single-cell analysis. Arch Neurol. 2012;69(4):523–6.CrossRef Sahm F, Capper D, Jeibmann A, et al. Addressing diffuse glioma as a systemic brain disease with single-cell analysis. Arch Neurol. 2012;69(4):523–6.CrossRef
3.
go back to reference Pouratian N, Asthagiri A, Jagannathan J, et al. Surgery insight: the role of surgery in the management of low-grade gliomas. Nat Clin Pract Neurol. 2007;3:628–39.CrossRef Pouratian N, Asthagiri A, Jagannathan J, et al. Surgery insight: the role of surgery in the management of low-grade gliomas. Nat Clin Pract Neurol. 2007;3:628–39.CrossRef
4.
go back to reference Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114(2):97–109.CrossRef Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114(2):97–109.CrossRef
5.
go back to reference Coons SW, Johnson PC, Scheithauer BW et al. Improving diagnostic accurancy and interobserver concordance in the classification and grading of primary gliomas. Cancer. 1997;79(7):1381–93.CrossRef Coons SW, Johnson PC, Scheithauer BW et al. Improving diagnostic accurancy and interobserver concordance in the classification and grading of primary gliomas. Cancer. 1997;79(7):1381–93.CrossRef
6.
go back to reference Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131:803–20.CrossRef Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131:803–20.CrossRef
7.
go back to reference Pignatti F, van den Bent M, Curran D, et al. Prognostic factors for survival in adult patients with cerebral low-grade glioma. J Clin Oncol. 2002;20(8):2076–84.CrossRef Pignatti F, van den Bent M, Curran D, et al. Prognostic factors for survival in adult patients with cerebral low-grade glioma. J Clin Oncol. 2002;20(8):2076–84.CrossRef
8.
go back to reference Karim ABMF, Maat B, Hatlevoll R, et al. A randomized trial on dose-response in radiation therapy of low grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) study 22844. Int J Radiat Oncol Biol Phys. 1996;36:549–56.CrossRef Karim ABMF, Maat B, Hatlevoll R, et al. A randomized trial on dose-response in radiation therapy of low grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) study 22844. Int J Radiat Oncol Biol Phys. 1996;36:549–56.CrossRef
9.
go back to reference Karim ABMF, Afra D, Cornu P. Randomized trial of the efficacy of radiotherapy for low-grade glioma in the adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council study BR04: an interim analysis. Int J Radiat Oncol Biol Phys. 2002;52:316–24.CrossRef Karim ABMF, Afra D, Cornu P. Randomized trial of the efficacy of radiotherapy for low-grade glioma in the adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council study BR04: an interim analysis. Int J Radiat Oncol Biol Phys. 2002;52:316–24.CrossRef
10.
go back to reference Shaw EG, Berkey B, Coons SW, et al. Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial. J Neurosurg. 2008;109(5):835–41.CrossRef Shaw EG, Berkey B, Coons SW, et al. Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial. J Neurosurg. 2008;109(5):835–41.CrossRef
11.
go back to reference Buckner JC, Shaw EG, Pugh SL, et al. Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma. N Engl J Med. 2016;374(14):1344–55.CrossRef Buckner JC, Shaw EG, Pugh SL, et al. Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma. N Engl J Med. 2016;374(14):1344–55.CrossRef
12.
go back to reference Lote K, Egeland T, Hager B, et al. Survival, prognostic factors, and therapeutic efficacy in low-grade glioma: a restrospective study in 379 patients. J Clin Oncol. 1997;15:3129–40. Lote K, Egeland T, Hager B, et al. Survival, prognostic factors, and therapeutic efficacy in low-grade glioma: a restrospective study in 379 patients. J Clin Oncol. 1997;15:3129–40.
13.
go back to reference Leighton C, Fisher B, Bauman G et al. Supratentorial low-grade glioma in adults: an analysis of prognostic factors and the timing of radiation. J Clin Oncol. 1997;15:1294–301.CrossRef Leighton C, Fisher B, Bauman G et al. Supratentorial low-grade glioma in adults: an analysis of prognostic factors and the timing of radiation. J Clin Oncol. 1997;15:1294–301.CrossRef
14.
go back to reference Smith JS, Chang EF, Lamborn KR et al. Role of extent of resection in the long term outcome of low-grade hemispheric glioma. J Clin Oncol. 2008;26:1338–45.CrossRef Smith JS, Chang EF, Lamborn KR et al. Role of extent of resection in the long term outcome of low-grade hemispheric glioma. J Clin Oncol. 2008;26:1338–45.CrossRef
15.
go back to reference Shibamoto Y, Kitakabu Y, Takahashi M et al. Supratentorial low-grade astrocytoma. Correlation of computed tomography findings with effect of radiation therapy and prognostic variables. Cancer. 1993;72(1):190–5.CrossRef Shibamoto Y, Kitakabu Y, Takahashi M et al. Supratentorial low-grade astrocytoma. Correlation of computed tomography findings with effect of radiation therapy and prognostic variables. Cancer. 1993;72(1):190–5.CrossRef
16.
go back to reference Baumert BG, Hegi ME, van den Bent MJ et al. Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033–26033): a randomised, open-label, phase 3 intergroup study. Lancet Oncol. 2016;17(11):1521–32.CrossRef Baumert BG, Hegi ME, van den Bent MJ et al. Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033–26033): a randomised, open-label, phase 3 intergroup study. Lancet Oncol. 2016;17(11):1521–32.CrossRef
17.
go back to reference Wijnenga MMJ, French PJ, Dubbink HJ, et al. The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis. Neuro Oncol. 2018;20(1):103–12.CrossRef Wijnenga MMJ, French PJ, Dubbink HJ, et al. The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis. Neuro Oncol. 2018;20(1):103–12.CrossRef
Metadata
Title
The Risk Assessment in Low-Grade Gliomas: An Analysis of the European Organization for Research and Treatment of Cancer (EORTC) and the Radiation Therapy Oncology Group (RTOG) criteria
Authors
Andrea Lanese
Enrico Franceschi
Alba A. Brandes
Publication date
01-12-2018
Publisher
Springer Healthcare
Published in
Oncology and Therapy / Issue 2/2018
Print ISSN: 2366-1070
Electronic ISSN: 2366-1089
DOI
https://doi.org/10.1007/s40487-018-0063-9

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