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Published in: Malaria Journal 1/2011

Open Access 01-12-2011 | Commentary

The relevance of non-human primate and rodent malaria models for humans

Authors: Jean Langhorne, Pierre Buffet, Mary Galinski, Michael Good, John Harty, Didier Leroy, Maria M Mota, Erica Pasini, Laurent Renia, Eleanor Riley, Monique Stins, Patrick Duffy

Published in: Malaria Journal | Issue 1/2011

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Abstract

At the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants. This was prompted by the concern of investigators that skepticism in the malaria community about the use and relevance of animal models, particularly rodent models of severe malaria, has impacted on funding decisions and publication of research using animal models. Several speakers took the opportunity to demonstrate the similarities between findings in rodent models and human severe disease, as well as points of difference. The variety of malaria presentations in the different experimental models parallels the wide diversity of human malaria disease and, therefore, might be viewed as a strength. Many of the key features of human malaria can be replicated in a variety of nonhuman primate models, which are very under-utilized. The importance of animal models in the discovery of new anti-malarial drugs was emphasized. The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material.
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Metadata
Title
The relevance of non-human primate and rodent malaria models for humans
Authors
Jean Langhorne
Pierre Buffet
Mary Galinski
Michael Good
John Harty
Didier Leroy
Maria M Mota
Erica Pasini
Laurent Renia
Eleanor Riley
Monique Stins
Patrick Duffy
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2011
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-10-23

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