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Diabetology & Metabolic Syndrome
Published in: Diabetology & Metabolic Syndrome 1/2017

Open Access 01-12-2017 | Research

The relationship between insulin sensitivity and heart rate-corrected QT interval in patients with type 2 diabetes

Authors: Xiao-hua Yang, Jian-bin Su, Xiu-lin Zhang, Li-hua Zhao, Feng Xu, Xue-qin Wang, Xing-bo Cheng

Published in: Diabetology & Metabolic Syndrome | Issue 1/2017

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Abstract

Background

Reduced insulin sensitivity not only contributes to the pathogenesis of type 2 diabetes but is also linked to multiple metabolic risk factors and cardiovascular diseases (CVD). A prolonged heart rate-corrected QT interval (QTc interval) is related to ventricular arrhythmias and CVD mortality and exhibits a high prevalence among type 2 diabetes patients. The aim of the study was to investigate the relationship between insulin sensitivity and the QTc interval in patients with type 2 diabetes.

Methods

This cross-sectional observational study recruited 2927 patients with type 2 diabetes who visited the Affiliated Haian Hospital and Second Affiliated Hospital of Nantong University. The insulin sensitivity index (Matsuda index, ISIMatsuda) derived from 75-g OGTT and other metabolic risk factors were examined in all patients. The QTc interval was estimated using a resting 12-lead electrocardiogram, and an interval longer than 440 ms was considered abnormally prolonged.

Results

The QTc interval was significantly and negatively correlated with the ISIMatsuda (r = −0.296, p < 0.001), and when the multiple linear regression analysis was adjusted for anthropometric parameters, metabolic risk factors, and current antidiabetic treatments, the QTc interval remained significantly correlated with the ISIMatsuda (β = −0.23, t = −12.63, p < 0.001). The proportion of patients with prolonged QTc interval significantly increased from 12.1% to 17.9%, 25.6% and 37.9% from the fourth to third, second and first quartile of the ISIMatsuda, respectively. After adjusting for anthropometric parameters by multiple logistic regression analysis, the corresponding odd ratios (ORs) for prolonged QTc interval of the first, second and third quartiles versus the fourth quartile of ISIMatsuda were 3.11 (95% CI 2.23–4.34), 2.09 (1.51–2.88) and 1.53 (1.09–2.14), respectively, and p for trend was <0.001.

Conclusions

Reduced insulin sensitivity is associated with an increase in the QTc interval in patients with type 2 diabetes.
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Metadata
Title
The relationship between insulin sensitivity and heart rate-corrected QT interval in patients with type 2 diabetes
Authors
Xiao-hua Yang
Jian-bin Su
Xiu-lin Zhang
Li-hua Zhao
Feng Xu
Xue-qin Wang
Xing-bo Cheng
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2017
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/s13098-017-0268-3

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