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01-12-2018 | Original Article

The QUALYOR (QUalité Osseuse LYon Orléans) study: a new cohort for non invasive evaluation of bone quality in postmenopausal osteoporosis. Rationale and study design

Authors: Roland Chapurlat, Jean-Baptiste Pialat, Blandine Merle, Elisabeth Confavreux, Florence Duvert, Elisabeth Fontanges, Farida Khacef, Sylvie Loiseau Peres, Anne-Marie Schott, Eric Lespessailles

Published in: Archives of Osteoporosis | Issue 1/2018

Abstract

Summary

The diagnostic performance of densitometry is inadequate. New techniques of non-invasive evaluation of bone quality may improve fracture risk prediction. Testing the value of these techniques is the goal of the QUALYOR cohort.

Introduction

The bone mineral density (BMD) of postmenopausal women who sustain osteoporotic fracture is generally above the World Health Organization definition for osteoporosis. Therefore, new approaches to improve the detection of women at high risk for fracture are warranted.

Methods

We have designed and recruited a new cohort to assess the predictive value of several techniques to assess bone quality, including high-resolution peripheral quantitative computerized tomography (HRpQCT), hip QCT, calcaneus texture analysis, and biochemical markers. We have enrolled 1575 postmenopausal women, aged at least 50, with an areal BMD femoral neck or lumbar spine T-score between − 1.0 and − 3.0. Clinical risk factors for fracture have been collected along with serum and blood samples.

Results

We describe the design of the QUALYOR study. Among these 1575 women, 80% were aged at least 60. The mean femoral neck T-score was − 1.6 and the mean lumbar spine T-score was −1.2. This cohort is currently being followed up.

Conclusions

QUALYOR will provide important information on the relationship between bone quality variables and fracture risk in women with moderately decreased BMD.

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Title: The QUALYOR (QUalité Osseuse LYon Orléans) study: a new cohort for non invasive evaluation of bone quality in postmenopausal osteoporosis. Rationale and study design
Authors: Roland Chapurlat
Jean-Baptiste Pialat
Blandine Merle
Elisabeth Confavreux
Florence Duvert
Elisabeth Fontanges
Farida Khacef
Sylvie Loiseau Peres
Anne-Marie Schott
Eric Lespessailles
Publication date: 01-12-2018
Publisher: Springer London
Published in: Archives of Osteoporosis / Issue 1/2018
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-017-0412-6

At a glance: The STEP trials

Springer Medicine

The QUALYOR (QUalité Osseuse LYon Orléans) study: a new cohort for non invasive evaluation of bone quality in postmenopausal osteoporosis. Rationale and study design

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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