Skip to main content
Top
Published in: Endocrine 2/2019

01-05-2019 | Original Article

The prescription rates of glucagon for hypoglycemia by pediatricians and physicians are low in Japan

Authors: Masaaki Matsumoto, Hiroyuki Awano, Yushi Hirota, Masashi Nagai, Ryosuke Bo, Atsuko Matsuoka, Tetsushi Hamaguchi, Takehito Takeuchi, Yasushi Nakagawa, Wataru Ogawa, Kazumoto Iijima

Published in: Endocrine | Issue 2/2019

Login to get access

Abstract

Purpose

Hypoglycemia is a common and life-threatening complication in type 1 diabetes mellitus (T1DM) patients. Current guidelines recommend glucagon for treating hypoglycemia in out-of-hospital settings; however, glucagon is reportedly underused in such patients. We conducted a doctor-oriented, questionnaire-based survey of pediatricians and physicians to determine the glucagon prescription rate and identify the reason(s) for its underuse in T1DM patients.

Methods

A questionnaire was mailed to 415 pediatricians and 200 physicians employed at 66 facilities with >100 general wards throughout Hyogo, Japan. The following variables were surveyed: doctor’s specialty, glucagon prescription rate, familiarity with glucagon use guidelines, barriers to prescribing glucagon, and attitude changes after education.

Results

After 16 doctors were found to have retired, 599 doctors were enrolled; 305 (187 pediatricians and 118 physicians) returned a completed questionnaire. In all, 45 pediatricians and 104 physicians were treating T1DM patients, of whom 24% and 28% reported prescribing glucagon, respectively. The guideline familiarity rate among pediatricians was lower than that among physicians. The major barrier to prescribing glucagon was the complex preparation procedure required by patients/caregivers. More than half of the doctors who did not prescribe glucagon began doing so after being educated about the guidelines.

Conclusion

The glucagon prescription rate was low among both pediatricians and physicians in Japan.
Literature
1.
go back to reference B. Karges, A. Schwandt, B. Heidtmann, O. Kordonouri, E. Binder, U. Schierloh, C. Boettcher, T. Kapellen, J. Rosenbauer, R.W. Holl, Association of insulin pump therapy vs insulin injection therapy with severe hypoglycemia, ketoacidosis, and glycemic control among children, adolescents, and young adults with type 1 diabetes. JAMA 318, 1358–1366 (2017)CrossRefPubMedPubMedCentral B. Karges, A. Schwandt, B. Heidtmann, O. Kordonouri, E. Binder, U. Schierloh, C. Boettcher, T. Kapellen, J. Rosenbauer, R.W. Holl, Association of insulin pump therapy vs insulin injection therapy with severe hypoglycemia, ketoacidosis, and glycemic control among children, adolescents, and young adults with type 1 diabetes. JAMA 318, 1358–1366 (2017)CrossRefPubMedPubMedCentral
2.
go back to reference T. Murata, K. Okazaki, K. Yanagisawa, K. Yamada, N. Kuribayashi, Y. Totsuka, T. Hiyoshi, M. Naka, M. Sugimoto, Y. Aoki, M. Waki, M. Furuya, H. Kitaoka, M. Oishi, I. Shimizu, H. Miyaoka, T. Yamamoto, K. Yamada, N. Sakane, Glucagon underutilized among type 1 diabetes mellitus patients in Japan. Diabetes Technol. Ther. 15, 748–750 (2013)CrossRefPubMed T. Murata, K. Okazaki, K. Yanagisawa, K. Yamada, N. Kuribayashi, Y. Totsuka, T. Hiyoshi, M. Naka, M. Sugimoto, Y. Aoki, M. Waki, M. Furuya, H. Kitaoka, M. Oishi, I. Shimizu, H. Miyaoka, T. Yamamoto, K. Yamada, N. Sakane, Glucagon underutilized among type 1 diabetes mellitus patients in Japan. Diabetes Technol. Ther. 15, 748–750 (2013)CrossRefPubMed
3.
go back to reference R. Alemzadeh, T. Berhe, D.T. Wyatt, Flexible insulin therapy with glargine insulin improved glycemic control and reduced severe hypoglycemia among preschool-aged children with type 1 diabetes mellitus. Pediatrics 115, 1320–1324 (2005)CrossRefPubMed R. Alemzadeh, T. Berhe, D.T. Wyatt, Flexible insulin therapy with glargine insulin improved glycemic control and reduced severe hypoglycemia among preschool-aged children with type 1 diabetes mellitus. Pediatrics 115, 1320–1324 (2005)CrossRefPubMed
4.
go back to reference T. Urakami, M. Habu, J. Suzuki, Diabetic ketoacidosis and severe hypoglycemia in management of type 1 diabetes during 2003-2013. Pediatr. Int. 56, 940 (2014)CrossRefPubMed T. Urakami, M. Habu, J. Suzuki, Diabetic ketoacidosis and severe hypoglycemia in management of type 1 diabetes during 2003-2013. Pediatr. Int. 56, 940 (2014)CrossRefPubMed
5.
go back to reference M. Namba, T. Iwakura, R. Nishimura, K. Akazawa, M. Matsuhisa, Y. Atsumi, J. Satoh, T. Yamauchi; Japan Diabetes Society (JDS) Committee for Surveys on Severe Hypoglycemia. The current status of treatment-related severe hypoglycemia in Japanese patients with diabetes mellitus: a report from the committee on a survey of severe hypoglycemia in the Japan Diabetes Society. J Diabetes Investig. 9, 642–656 (2018) M. Namba, T. Iwakura, R. Nishimura, K. Akazawa, M. Matsuhisa, Y. Atsumi, J. Satoh, T. Yamauchi; Japan Diabetes Society (JDS) Committee for Surveys on Severe Hypoglycemia. The current status of treatment-related severe hypoglycemia in Japanese patients with diabetes mellitus: a report from the committee on a survey of severe hypoglycemia in the Japan Diabetes Society. J Diabetes Investig. 9, 642–656 (2018)
6.
go back to reference T.T. Ly, D.M. Maahs, A. Rewers, D. Dunger, A. Oduwole, T.W. Jones, International Society for Pediatric and Adolescent Diabetes, ISPAD Clinical Practice Consensus Guidelines 2014. Assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr. Diabetes 15, 180–192 (2014).CrossRefPubMed T.T. Ly, D.M. Maahs, A. Rewers, D. Dunger, A. Oduwole, T.W. Jones, International Society for Pediatric and Adolescent Diabetes, ISPAD Clinical Practice Consensus Guidelines 2014. Assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr. Diabetes 15, 180–192 (2014).CrossRefPubMed
7.
go back to reference E.R. Seaquist, J. Anderson, B. Childs, P. Cryer, S. Dagogo-Jack, L. Fish, S.R. Heller, H. Rodriguez, J. Rosenzweig, R. Vigersky, Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. J. Clin. Endocrinol. Metab. 98, 1845–1859 (2013)CrossRefPubMed E.R. Seaquist, J. Anderson, B. Childs, P. Cryer, S. Dagogo-Jack, L. Fish, S.R. Heller, H. Rodriguez, J. Rosenzweig, R. Vigersky, Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. J. Clin. Endocrinol. Metab. 98, 1845–1859 (2013)CrossRefPubMed
8.
go back to reference J.J. Chamberlain, R.R. Kalyani, S. Leal, A.S. Rhinehart, J.H. Shubrook, N. Skolnik, W.H. Herman, Treatment of type 1 diabetes: synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes. Ann. Intern. Med. 167, 493–498 (2017)CrossRefPubMed J.J. Chamberlain, R.R. Kalyani, S. Leal, A.S. Rhinehart, J.H. Shubrook, N. Skolnik, W.H. Herman, Treatment of type 1 diabetes: synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes. Ann. Intern. Med. 167, 493–498 (2017)CrossRefPubMed
9.
go back to reference G. Harris, A. Diment, M. Sulway, M. Wilkinson, Glucagon administration - underevaluated and undertaught. Pract. Diabetes Int. 18, 22–25 (2001)CrossRef G. Harris, A. Diment, M. Sulway, M. Wilkinson, Glucagon administration - underevaluated and undertaught. Pract. Diabetes Int. 18, 22–25 (2001)CrossRef
10.
go back to reference T. Pearson, Glucagon as a treatment of severe hypoglycemia: safe and efficacious but underutilized. Diabetes Educ. 34, 128–134 (2008)CrossRefPubMed T. Pearson, Glucagon as a treatment of severe hypoglycemia: safe and efficacious but underutilized. Diabetes Educ. 34, 128–134 (2008)CrossRefPubMed
11.
go back to reference W. Clarke, T. Jones, A. Rewers, D. Dunger, G.J. Klingensmithe, International Society for Pediatric and Adolescent Diabetes clinical practice consensus guidelines 2006-2008 (Japanese translation). J. Jpn Pediatr. Soc. 112, 1748–1757 (2008). (Japanese) W. Clarke, T. Jones, A. Rewers, D. Dunger, G.J. Klingensmithe, International Society for Pediatric and Adolescent Diabetes clinical practice consensus guidelines 2006-2008 (Japanese translation). J. Jpn Pediatr. Soc. 112, 1748–1757 (2008). (Japanese)
12.
go back to reference M. Haneda, M. Noda, H. Origasa, H. Noto, D. Yabe, Y. Fujita, A. Goto, T. Kondo, E. Araki, Japanese Clinical Practice Guideline for Diabetes 2016. J. Diabetes Investig. 9, 657–697 (2018)CrossRefPubMedCentral M. Haneda, M. Noda, H. Origasa, H. Noto, D. Yabe, Y. Fujita, A. Goto, T. Kondo, E. Araki, Japanese Clinical Practice Guideline for Diabetes 2016. J. Diabetes Investig. 9, 657–697 (2018)CrossRefPubMedCentral
13.
go back to reference J. Aman, L. Wranne, Hypoglycaemia in childhood diabetes. II. Effect of subcutaneous or intramuscular injection of different doses of glucagon. Acta Paediatr. Scand. 77, 548–553 (1988)CrossRefPubMed J. Aman, L. Wranne, Hypoglycaemia in childhood diabetes. II. Effect of subcutaneous or intramuscular injection of different doses of glucagon. Acta Paediatr. Scand. 77, 548–553 (1988)CrossRefPubMed
14.
go back to reference M.W. Haymond, B. Schreiner, Mini-dose glucagon rescue for hypoglycemia in children with type 1 diabetes. Diabetes Care 24, 643–645 (2001)CrossRefPubMed M.W. Haymond, B. Schreiner, Mini-dose glucagon rescue for hypoglycemia in children with type 1 diabetes. Diabetes Care 24, 643–645 (2001)CrossRefPubMed
15.
go back to reference The Japan Diabetes Society, The Japanese Society for Pediatric Endocrinology, Pediatric and Adolescent Diabetes Consensus Guidelines, p. 262-167 (Nankodo, Tokyo 2015) (Japanese) The Japan Diabetes Society, The Japanese Society for Pediatric Endocrinology, Pediatric and Adolescent Diabetes Consensus Guidelines, p. 262-167 (Nankodo, Tokyo 2015) (Japanese)
16.
go back to reference The Japan Diabetes Society, Japanese Clinical Practice Guideline for Diabetes 2016, p. 449-472 (Nankodo, Tokyo 2016) (Japanese) The Japan Diabetes Society, Japanese Clinical Practice Guideline for Diabetes 2016, p. 449-472 (Nankodo, Tokyo 2016) (Japanese)
17.
go back to reference A.E. Pontiroli, Intranasal glucagon: a promising approach for treatment of severe hypoglycemia. J. Diabetes Sci. Technol. 9, 38–43 (2015)CrossRefPubMed A.E. Pontiroli, Intranasal glucagon: a promising approach for treatment of severe hypoglycemia. J. Diabetes Sci. Technol. 9, 38–43 (2015)CrossRefPubMed
18.
go back to reference U. Hövelmann, B.V. Bysted, U. Mouritzen, F. Macchi, D. Lamers, B. Kronshage, D.V. Møller, T. Heise, Pharmacokinetic and pharmacodynamic characteristics of dasiglucagon, a novel soluble and stable glucagon analog. Diabetes Care 41, 531–537 (2018)CrossRefPubMed U. Hövelmann, B.V. Bysted, U. Mouritzen, F. Macchi, D. Lamers, B. Kronshage, D.V. Møller, T. Heise, Pharmacokinetic and pharmacodynamic characteristics of dasiglucagon, a novel soluble and stable glucagon analog. Diabetes Care 41, 531–537 (2018)CrossRefPubMed
19.
go back to reference DIAMOND Project Group, Incidence and trends of childhood type 1 diabetes worldwide 1990-1999. Diabet. Med. 23, 857–866 (2006)CrossRef DIAMOND Project Group, Incidence and trends of childhood type 1 diabetes worldwide 1990-1999. Diabet. Med. 23, 857–866 (2006)CrossRef
20.
go back to reference A. Coppola, L. Sasso, A. Bagnasco, A. Giustina, C. Gazzarsuo, The role of patient education in the prevention and management of type 2 diabetes: an overview. Endocrine 53, 18–27 (2016)CrossRefPubMed A. Coppola, L. Sasso, A. Bagnasco, A. Giustina, C. Gazzarsuo, The role of patient education in the prevention and management of type 2 diabetes: an overview. Endocrine 53, 18–27 (2016)CrossRefPubMed
Metadata
Title
The prescription rates of glucagon for hypoglycemia by pediatricians and physicians are low in Japan
Authors
Masaaki Matsumoto
Hiroyuki Awano
Yushi Hirota
Masashi Nagai
Ryosuke Bo
Atsuko Matsuoka
Tetsushi Hamaguchi
Takehito Takeuchi
Yasushi Nakagawa
Wataru Ogawa
Kazumoto Iijima
Publication date
01-05-2019
Publisher
Springer US
Published in
Endocrine / Issue 2/2019
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-018-1793-z

Other articles of this Issue 2/2019

Endocrine 2/2019 Go to the issue

Endocrine imaging

Pituitary crush

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.