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Critical Care
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Letter

The pharmacokinetic challenge of treating invasive aspergillosis complicating severe influenzae assisted by extracorporeal membrane oxygenation

Authors: Hadrien Winiszewski, Anne-Claire Rougny, Jennifer Lagoutte-Renosi, Laurence Millon, Gilles Capellier, Jean-Christophe Navellou, Gael Piton, Anne-Laure Clairet

Published in: Critical Care | Issue 1/2018

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Excerpt

Invasive aspergillosis (IA) complicates 19% of patients requiring ICU admission for severe influenza [1]. Despite recent development of isavuconazole, voriconazole remains the first therapeutic option for IA among patients without hematological malignancy [2]. However, among patients requiring the use of extracorporeal membrane oxygenation (ECMO) as rescue therapy for extremely severe acute respiratory failure [1], the use of ECMO per se has been reported as a cause of sequestration of voriconazole on the membrane. This phenomenon could induce low plasma concentrations of voriconazole and, therefore, limited efficacy [3]. …
Literature
1.
Schauwvlieghe AFAD, Rijnders BJA, Philips N, et al. Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study. Lancet Respir Med. 2018;6(10):782–92.
2.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, et al. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2018;24(Suppl 1):e1–e38.
3.
Mehta NM, Halwick DR, Dodson BL, et al. Potential drug sequestration during extracorporeal membrane oxygenation: results from an ex vivo experiment. Intensive Care Med. 2007;33:1018–24.CrossRef
Metadata
Title
The pharmacokinetic challenge of treating invasive aspergillosis complicating severe influenzae assisted by extracorporeal membrane oxygenation
Authors
Hadrien Winiszewski
Anne-Claire Rougny
Jennifer Lagoutte-Renosi
Laurence Millon
Gilles Capellier
Jean-Christophe Navellou
Gael Piton
Anne-Laure Clairet
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-2285-5

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