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Open Access 01-04-2017 | Case Report

The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report

Authors: Mayu Morita, Seiji Asoda, Kazuyuki Tsunoda, Tomoya Soma, Taneaki Nakagawa, Masayori Shirakawa, Hirofumi Shoji, Hisao Yagishita, Takeji Nishikawa, Hiromasa Kawana

Published in: Odontology | Issue 2/2017

Abstract

Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.

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Title: The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report
Authors: Mayu Morita
Seiji Asoda
Kazuyuki Tsunoda
Tomoya Soma
Taneaki Nakagawa
Masayori Shirakawa
Hirofumi Shoji
Hisao Yagishita
Takeji Nishikawa
Hiromasa Kawana
Publication date: 01-04-2017
Publisher: Springer Japan
Published in: Odontology / Issue 2/2017
Print ISSN: 1618-1247
Electronic ISSN: 1618-1255
DOI: https://doi.org/10.1007/s10266-016-0255-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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